Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"olfactory receptor"”.
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Functional and structural analyses of an olfactory receptor from Drosophila melanogaster
… family of integral membrane proteins, called olfactory receptors (ORs), that mediate the transduction of odorant binding into a neuronal signal. A functional assay for insect ORs was developed utilising calcium imaging in Sf9 cells. The Drosophila melanogaster OR, Or22a, was expressed using …
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Developmental influences of thyroid hormones on the rat olfactory receptor sheet
… hormones on the postnatal development of the olfactory receptor sheet (epithelium) of the rat. Quantitative, light microscopic morphometric and cell count studies were carried out on the olfactory epithelium of growing normal, hypothyroid, hypothyroid/recovery and hyperthyroid rats to measure …
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Large-scale production and characterization of an engineered human olfactory receptor
… The basis of this sensitivity are the olfactory (smell) receptors - a large, highly related class of sensory G-protein coupled receptors that function together combinatorially to allow discrimination between a wide range of volatile and soluble molecules. However, the structural and …
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Starved State Dependent Modulation of Olfactory Receptor Neuron Function in Drosophila melanogaster larvae
The ability of olfactory neurons to locate food sources underlies survival in most species of the animal kingdom. This ability of olfactory neurons to process environmental information is often modulated by the animal's internal state such as hunger. The peripheral end of the olfactory circuit …
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Investigation of Age Related Differences in the Rewiring of P2-Olfactory Receptor Neurons
Olfactory receptor neurons (ORNs) maintain the ability to regenerate. These neurons reside in the olfactory epithelium and project axons that connect to the olfactory bulbs. Despite the diffuse distribution of ORNs in the olfactory epithelium, they converge at discrete glomeruli in the olfactory …
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Establishing Neuronal Diversity: Regulation of olfactory receptor neuron specification and axon guidance in Drosophila
… remain largely unknown. We use the Drosophila olfactory system as model to understand nervous system development because of the powerful genetic tools and the workable level of neuronal diversity, which contains 50 classes of olfactory receptor neurons (ORNs). Each class of neurons is defined …
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Olfactory Receptor Antagonism in the OR-I7 Aldehyde Receptor and the Mammalian Olfactory System
… is initiated when an odorant binds and activates olfactory receptors (ORs) within the nose. Chapter 1 studies the structural requirements for activation of the OR-I7 aldehyde receptor. Octanal is an agonist of the OR-I7 receptor. 4-Ethylcyclohexylacetaldehyde (<strong>1.1)</strong>, with a …
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The tangled history of olfaction in African mole-rats, Bathyergidae: insights from Olfactory Receptor genes
This thesis reports the first assessment of OR variation in Bathyergidae, and therefore, the first for a family of subterranean mammals. Using a PCR-sequencing approach, 178 unique OR sequences, corresponding to 119 unique OR genes are characterised from 14 mole-rat species. Bathyergidae OR genes …
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Methyl-CpG-Binding domain proteins and histone deacetylases in the stage-specific differentiation of olfactory receptor neurons
… differentiation of neurons. In the olfactory epithelium (OE), where neurogenesis is continuous and the cells demonstrate a laminar organization with a developmental hierarchy, we identified sequential, transitional stages of differentiation likely mediated by different DNMT, MBD and …
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Immortalisation, characterisation and differentiation of temperature sensitive cell lines from the Olfactory Neuroepithelium
Embryonic olfactory neuroepithelium provides a useful experimental system for the study of olfactory neurogenesis. As a substrate for experimental neural cell biology, olfactory neuroepithelium is of unique interest since, unlike other neural cells, olfactory neurons are continually replaced - a …
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Leveraging high-throughput datasets for studies of gene regulation
… for the monoallelic and monogenic expression of olfactory receptor genes in mice. Lastly, signatures of functional, bound RNA regions provide insight into a potential protocol-specific bias and produce a new avenue for de novo discovery of functional regions.
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De Novo Heme Protein Design
"We have developed an interesting hypothesis for Olfactory Receptor (OR) mechanism. We are so sensitive to thiols and amines that the most natural way to explain this is that OR is a metalloprotein. We have found a consensus sequence ""HXXCE"" in the 4--5 loop of ORs, which not only binds strongly …
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Specific Roles of Kal-1 in Olfaction: A Model of Kallmann Syndrome in Drosophila
… specifically localizes to the dendrites of olfactory receptor neurons (ORNs) throughout development. The dendrites of ORNs sense odorants in the environment including the Drosophila melanogaster male-specific pheromone 11-cis-vaccenyl acetate, which is known to inhibit male-male mating …
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Synthetic sensing systems in Saccharomyces cerevisiae
… expression of different recognition elements or receptors and their coupling to the yeast mating pathway can enable sensing of a variety of ligands. In this work, we have engineered a yeast strain to functionally express a heterologous human olfactory receptor gene which can be coupled to the …
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Analysis of accelerants by gas chromatography-mass spectrometry and cyclic voltammetry for biosensor development
… detection techniques, biosensors, the human olfactory system and electrochemical analytical techniques such as cyclic voltammetry. An overview of all these areas allows a theory to be brought together, that a biosensor could be created for the presumptive detection of accelerants at fire …
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A sexually dimorphic circuit switch in higher olfactory centres
A sexually dimorphic circuit switch in higher olfactory centres In Drosophila the male sex pheromone cis-vaccenyl acetate (cVA) elicits different behaviours in males and females: while males are repelled by cVA, it stimulates female receptivity. However, olfactory receptor neurons and their …
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Axon Guidance In The Mouse Olfactory System
Within the mouse olfactory system, 1200 different types of olfactory sensory neurons use molecular cues to appropriately target stereotyped locations within the olfactory bulb. Recent studies reveal that some of these molecular cues are regulated by olfactory receptor mediated neuronal activity. …
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Highly Sensitive and Selective Gas Sensors Based on Vertically Aligned Metal Oxide Nanowire Arrays
<p>Mimicking the biological olfactory systems that consist of olfactory receptor arrays with large surface area and massively-diversified chemical reactivity, three dimensional (3D) metal oxide nanowire arrays were used as the active materials for gas detection. Metal oxide nanowire arrays share …
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