Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"olfactory epithelium"”.
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Diversity of transduction mechanisms in receptor neurons of the main olfactory epithelium in <i>Xenopus laevis</i> tadpoles
Die vorliegende Untersuchung berichtet über Reizantworten olfaktorischer Rezeptorzellen (ORZ) in einer neuartigen Gewebeschnittpräparation des olfaktorischen Epithels von larvalen Xenopus laevis nach Applikation von Aminosäuren und pharmakologischen Wirkstoffen, die den cAMP-vermittelten …
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Investigation of Age Related Differences in the Rewiring of P2-Olfactory Receptor Neurons
Olfactory receptor neurons (ORNs) maintain the ability to regenerate. These neurons reside in the olfactory epithelium and project axons that connect to the olfactory bulbs. Despite the diffuse distribution of ORNs in the olfactory epithelium, they converge at discrete glomeruli in the olfactory …
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Axon Development and Synapse Formation in Olfactory Sensory Neurons
The olfactory epithelium (OE) possesses the rare capacity among neuronal tissues to regenerate throughout life. As a result, progenitor cells continuously proliferate and differentiate into olfactory sensory neurons (OSNs) that project their axons to the olfactory bulb (OB) where they establish …
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Olfactory progenitor cell transplantation into the mammalian inner ear
… part of this thesis examines the hypothesis that olfactory neurosphere (ONS) and progenitor cells harvested from the olfactory epithelium represent a viable source of graft material for potential therapeutic applications in the inner ear. Olfactory epithelium represents a unique source of …
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Odorant receptors: regulation, signaling, and expression
Olfactory signal transduction is initiated by binding of odorous ligands to G protein-coupled odorant receptors, resulting in the activation of G protein and second messengers that culminates in the generation of action potentials to relay this signal to the brain for odor recognition. This …
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Developmental influences of thyroid hormones on the rat olfactory receptor sheet
… hormones on the postnatal development of the olfactory receptor sheet (epithelium) of the rat. Quantitative, light microscopic morphometric and cell count studies were carried out on the olfactory epithelium of growing normal, hypothyroid, hypothyroid/recovery and hyperthyroid rats to measure …
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The Guidance of Olfactory Sensory Axons to Identifiable Protoglomeruli in the Larval Zebrafish Olfactory Bulb
During development, sensory neurons in the olfactory epithelium extend axons into the olfactory bulb. The earliest axons to enter the bulb terminate onto distinct neuropilar condensations called protoglomeruli. Protoglomeruli are thought to segregate into individual glomeruli later in development. …
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Decoding Gating Properties of the Pannexin1 Channel: ATP Release and pH Sensitivity and the Potential Role in Health and Disease
… function of Panx1. Here, the function in the olfactory epithelium was investigated using Panx1 knock out mice. Functional analysis in vivo confirmed a role in olfaction suggesting that Panx1 is one of several alternative ATP release pathways. Since epileptic and ischemic events cause …
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Decoupling Motion from Sensory Data: An Emergent Property of a Neural Population in the Piriform Cortex
… rate is crucial to flexibly explore the olfactory environment. Inhalation gates the perception of scents, and the act of sniffing is necessary for the olfactory percept. In olfaction, sniffing increases the airflow velocity inside the nostrils and the number of odor molecules that contact …
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A Comparison of Olfactory Organ Development and Feeding Behavior in Larval Fathead Minnows, Pimephales promelas Rafinesque
… Furthermore, some studies have shown the olfactory system to be adversely impacted by environmental contaminants and low pH. Since the fathead minnow is a commercially raised baitfish in the aquaculture industry, and serves as a standard test organism for bioassays and reaction studies of …
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Olfactory Ensheathing Cell Development: A Transcriptome Profiling Approach
Olfactory ensheathing cells (OECs), the glia of the olfactory nerve, are promising candidates for patient-specific cell-mediated repair of both peripheral nerves and the spinal cord. The recent discovery that OECs originate from the neural crest, rather than the olfactory epithelium as previously …
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Axon Guidance In The Mouse Olfactory System
Within the mouse olfactory system, 1200 different types of olfactory sensory neurons use molecular cues to appropriately target stereotyped locations within the olfactory bulb. Recent studies reveal that some of these molecular cues are regulated by olfactory receptor mediated neuronal activity. …
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THE ROAD LESS TAKEN: CHARACTERIZING THE TRIGEMINAL NERVE ROUTE OF NEUROINVASION BY RESPIRATORY SARS-COV-2
… and alterations in consciousness. Although the olfactory nerve is widely accepted as the primary route of neuroinvasion by which the etiological agent SARS-CoV-2 invades the brain, the trigeminal nerve may serve as an additional, yet often overlooked, neuroinvasive route. We initially conducted …
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Modulation and Ligand Selectivity of Mammalian Odorant Receptors
… 1000 in mouse. Central to the question of how olfactory stimuli are represented at the peripheral level is defining the ligand selectivity and activity regulation of ORs.</p><p>Processing of chemosensory signals in the brain is dynamically regulated in part by an animal’s physiological state. …
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Proteomic analysis of the olfactory mucosa, thoracic aorta, urinary bladder, and descending colon of smooth muscle alpha actin null mutant mice
… identified in the aorta, bladder, colon, and olfactory ensheathing cell population in the olfactory nervous system. These include impaired vascular contractility, thoracic aortic aneurysms and dissections, hypocontractile bladders, gastrointestinal hypoperistalsis, and pathological OEC …
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The Expression of Matrix Metalloproteinase-9 and -2 in Olfactory Injury and Recovery
The olfactory system has the remarkable capacity for neurogenesis following injury. However, the molecular mechanisms important for reinnervation of the olfactory bulb (OB) remain unknown. The matrix metalloproteinases (MMPs) are important components in many central nervous system (CNS) injury …
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Discovery and Characterization of the Polycomb Repressive Complex 1 of C. Elegans
… mammalian homologs of which are coexpressed in olfactory epithelium and hematopoietic cells. Our data explain the locomotory defects of unc-3 mutants and suggest that interactions between unc-3 and pag-3 homologs in other species may be functionally important. The second chapter of the thesis is …
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Identification, regulation and lineage tracing of embryonic olfactory progenitors
… zone and dentate gyrus in the brain, and olfactory epithelium (OE) in the periphery. Cell replacement after death or injury, occurs to varying degrees in neural tissue, and is thought to be dependent upon the biological responses of stem and/or progenitor cells. Despite the progress made …
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Methyl-CpG-Binding domain proteins and histone deacetylases in the stage-specific differentiation of olfactory receptor neurons
… differentiation of neurons. In the olfactory epithelium (OE), where neurogenesis is continuous and the cells demonstrate a laminar organization with a developmental hierarchy, we identified sequential, transitional stages of differentiation likely mediated by different DNMT, MBD and …
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Cell Signaling Components of the Drosophila Circadian Pacemaker
… Previous work performed in the mammalian olfactory epithelium suggests that specific glycan modifications are required for AC3 enzymatic activity and that these modifications rely upon a specific glycosyltransferase: beta-3GnT2). I report that knockdown of CG30036, the Drosophila homolog …
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