Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"olefin cross-metathesis"”.
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Suzuki-Miyaura mediated biphenyl synthesis: a spotlight on the boronate coupling partner
… derivatives were also synthesised by using the olefin cross-metathesis reaction of 4-vinylphenylboronic acid pinacol ester. A solid state crystallographic study was undertaken on a small library of methylbiphenylamides to compare the crystal structures of isomers or biphenyls with different …
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Exploring IPC Synthase: A POTENTIAL ANTI -LEISHMANIAL DRUG TARGET
… acid. The prepared alkenes were utilised in olefin cross metathesis reactions to yield a library of ceramide mimics variable in the sphingosine backbone. Deprotection-acylation sequence of the protected amino group resulted in variable N-acyl ceramide mimics. Screening of the substrate mimics …
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Towards the Structural Elucidation and Total Synthesis of Hemicalide: Assignment of the C29-C46 Region
… union of the C29-C35 and C34-C46 fragments, by olefin cross metathesis, to produce three diastereomers of the fully elaborated C29-C46 region. This work allowed the relative stereochemistry of C31 and C32 to be assigned and established the relationship between the C27-C32 and C36-C45 …
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Design and Synthesis of Complex and Fluorescent Labeled Cellulose-Based Derivatives for Orally Administered Drug Delivery Systems
… via appending bile salt substituents using olefin cross-metathesis. I ascertained that high performance crystallization inhibitors can be achieved with enhanced hydrophilicity by the marriage of two classes crystallization inhibitors (cellulose and bile salts), as illustrated with the …
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Synthesis and Structure-Property Relationships of Polysaccharide-Based Block Copolymers and Hydrogels
… solvolysis with an ω-unsaturated alcohol. Then, olefin cross-metathesis, a known versatile and mild tool for polysaccharide chemical modification, was used to couple the trimethyl cellulose block with various polymer blocks containing acrylates. To demonstrate the method, trimethyl …
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Design and Synthesis of Cellulose Ether Derivatives for Oral Drug Delivery
… new synthetic techniques and powerful tools. Olefin cross-metathesis (CM) is a mild, efficient and modular chemistry with extensive applications in organic, polymer, and polysaccharide chemistry. Successful CM can be achieved by appending olefin “handles” from cellulose esters and reacting …
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Chemical Modification of Cellulose Esters for Oral Drug Delivery
… We demonstrated the viability of chemoselective olefin hydroboration-oxidation in the synthesis of cellulose omega]-hydroxyesters in the presence of ester groups. Cellulose esters with terminally olefinic side chains were transformed to the target products by two-step, one-pot …