Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"ogg1"”.
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Disruption of 8-hydroxy-2'-deoxyguanosine DNA Glycosylase (OGG1) Antioxidant Response Capacity by Sodium Arsenite
… pathway. Transcriptional regulation of human Ogg1 is sensitive to redox changes via modulation of intracellular glutathione. In response to changes in glutathione, changes in hOgg1 transcription occur similar to genes regulated by the transcription factor Nrf2. It was determined that positions …
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Disruption of 8-hydroxy-2'-deoxyguanosine DNA Glycosylase (OGG1) Antioxidant Response Capacity by Sodium Arsenite
… pathway. Transcriptional regulation of human Ogg1 is sensitive to redox changes via modulation of intracellular glutathione. In response to changes in glutathione, changes in hOgg1 transcription occur similar to genes regulated by the transcription factor Nrf2. It was determined that positions …
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DNA Repair Mechanisms, Aflatoxin B1-Induced DNA Damage and Carcinogenesis
… Mice deficient in 8-oxoguanine glycosylase (OGG1, the rate-limiting enzyme in repair of oxidized guanine), mice heterozygous for OGG1, and wild type mice, were exposed to a single tumourigenic dose (50 mg/kg) of AFB1. Neither ogg1 genotype nor AFB1 treatment affected levels of oxidized …
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Altered DNA Repair, Antioxidant and Cellular Proliferation Status as Determinants of Susceptibility to Methylmercury Toxicity in Vitro
… oxoguanine glycosylase 1-null (Ogg1-/-) murine embryonic fibroblasts (MEFs); and, (2) human Ogg1 (hOgg1)- or formamidopyrimidine glycosylase (Fpg)-expressing human embryonic kidney (HEK) cells; reciprocal in vitro cellular models with deficient and enhanced ability to repair …
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Effect of mitochondrial respiratory defecton hepatocellular carcinoma :Involvement of mtOGG1 and NUPR1
… 8-oxoguanine DNA glycosylase/lyase (mtOGG1), a mitochondrial DNA repair enzyme; similar results were obtained with human hepatocellular carcinoma tissues. Among several OGG1-2 variants with a mitochondrialtargeting sequence (OGG1-2a, -2b, -2c, -2d, and -2e), OGG1-2a was the major …
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DIFFERENTIATION-INDUCED CHANGES IN ANTIOXIDANT CAPACITY AND ANTIOXIDANT RESPONSE IN SH-SY5Y CELLS: ROLE OF NRF2
… (tBHQ). The levels of GSH, Mn-SOD, HO and OGG1 which are all induced by Nrf2 were determined. The results of the experiment showed that differentiated (post-mitotic) and undifferentiated (mitotic) cells responded similarly to Nrf2 induction as was observed in the higher levels of GSH, HO, …
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DIFFERENTIATION-INDUCED CHANGES IN ANTIOXIDANT CAPACITY AND ANTIOXIDANT RESPONSE IN SH-SY5Y CELLS: ROLE OF NRF2
… (tBHQ). The levels of GSH, Mn-SOD, HO and OGG1 which are all induced by Nrf2 were determined. The results of the experiment showed that differentiated (post-mitotic) and undifferentiated (mitotic) cells responded similarly to Nrf2 induction as was observed in the higher levels of GSH, HO, …
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Susceptibilidad al cáncer colorrectal familiar no polipósico con tumores estables a microsatélites (HNPCC-X)
… se estudió el estado de los genes reparadores OGG1, MUTYH y MTH en línea germinal, la tasa de transversiones somáticas G>T en el gen KRAS y los niveles de 8OHdG en núcleos de células tumorales. a. Como resultado del estudio genético de los genes reparadores se encontraron dos variantes raras …
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Shedding Light on the Biological Effects of Ionising Radiation on DNA Using Advanced Optical Microscopy
… and localisation of DSB (gammaH2AX) and non-DSB (OGG1) clusters were measured at CDD sites using immunofluorescence and confocal microscopy (CM). Slower repair kinetics were observed for high-LET alpha-particles compared to low-LET gamma-rays. Additionally, PARP inhibitor Olaparib in combination …
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Functional DNA repair capacity assays : a focus on base excision repair
… specific fluorescent reporter plasmids for OGG1, AAG, MUTYH, UNG and APE1. Inter-individual differences in DNA repair capacity of a panel of cell lines derived from healthy individuals have been measured. Regression models that incorporate these measurements have been developed in order to …
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Biological response to 8-oxoguanine base released during DNA base excision repair
… initiated by 8-oxoguanine DNA glycosylase (OGG1) excises 8-oxo-Gua lesions from nuclear and mitochondrial DNA, releasing the free oxidized base. It is well-established that failure to repair 8-oxo-Gua can result in mutagenesis and carcinogenesis; however, the cellular response to free …
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Gene expression of DNA repair proteins in colorectal cancer and medulloblastoma
… base excision repair genes Neil1, Neil2, Neil3, Ogg1, and Nthl1, the nucleotide excision repair gene Ercc1 and the mismatch repair gene Mlh1 in colorectal cancer (CRC) tumours and matched normal colon tissue. The project was then extended to analyse a further sixteen colon samples that focused on …
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Replication-associated base excision repair Of oxidized bases in the mammalian genome
… Four mammalian DNA glycosylases, namely, OGG1 and NTH1 in the Nth family, and NEIL1 and NEIL2 in the Nei family, with overlapping substrate range initiate BER by excising oxidized base lesions and cleaving the DNA strand. NEIL1 prefers oxidized pyrimidines or ring-opened purines as …
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Genetic Susceptibility to Arsenic Exposure and Arsenical Skin Lesion Prevalence in Bangladesh
… relationship between SNPs in DNA repair genes (OGG1, rs1052133; XRCC1, rs25487 and rs1799782; XRCC3, rs861539; ERCC2, rs1052559; ERCC5, rs17655; and LIG4, rs1805388) and skin lesion prevalence, as well as possible interactions of these associations on the additive scale by various environmental …