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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 220 for “"off-target"”.

  1. Social functioning in older adults with high levels of off-target verbosity

    Basevitz, Paul1997

    … among older adults who exhibited high levels of Off-Target Verbosity (OTV), a conversational style that is characterized by an abundance of unfocussed speech. It was hypothesized that such individuals would tend to exhibit socially maladaptive behaviour and that the pattern of excessive and …

    concordia Repository record

  2. Búsqueda de interacciones off-target usando el fármaco Amiodarona como caso de estudio

    Ballester Badenes, MartaUniversitat Oberta de Catalunya (UOC)2021

    … report protein pockets responsible for producing off-target effects. Four notable adverse effects were obtained for this drug: hepatic steatosis, oxidative stress, metabolic acidosis/diuresis, and pulmonary toxicity. The first three were obtained by BioGPS, the last was notified by means of a …

    catalunya Repository record

  3. Antioxidant system remodeling underlies off-target effects of anti BCMA-Targeted Immunotherapy in Multiple Myeloma [Il rimodellamento del sistema antiossidante è alla base degli effetti off-target dell’immunoterapia anti-BCMA nel Mieloma Multiplo]

    LA SPINA, ENRICOUniversità degli studi di Catania2026

    … sviluppo di resistenza e da effetti collaterali off-target. In questo lavoro di tesi è stato adottato un approccio integrato proteomico, lipidomico e funzionale per definire i determinanti molecolari della risposta cellulare a BeMa. L’analisi proteomica del siero di donatori sani e pazienti con …

    catania Repository record

  4. Design, Off-Target Toxicity, and Intracellular Processing of Nucleotide-Modified Messenger RNAs for Human Therapies

    Mulroney, ThomasUniversity of Cambridge2020

    … applications. IVT mRNA is transfected into target cells, translated, and the fully-synthesised encoded protein exerts a therapeutic effect via specific mechanisms. IVT mRNAs have been applied to treatment of inherited protein deficiencies, tissue reprogramming, cancer immunotherapy, genome …

    cambridge Repository record

  5. APPLICATION OF STRUCTURAL, MOLECULAR, AND PROTOEMIC STUDIES TO INVESTIGATE ON-TARGET AND OFF-TARGET MECHANISMS OF LORLATINIB RESISTANCE IN ALK DRIVEN NEUROBLASTOMA

    Witek, Gabriela, Maria2023

    … patient survival because of development of targeted therapies. In neuroblastoma, a common childhood cancer, approval of anti-GD2 immune therapy has improved patient survival and discovery of anaplastic lymphoma kinase (ALK) receptor activating mutations and amplification has provided hope to …

    penn Repository record

  6. Bioinformatics pipeline development for analyses of data generated by target capture-based Next-Generation Sequencing, to characterise mutations and the utility of using off-target sequences to detect genomic imbalances in Multiple Myeloma patients.

    Coysh, AlixResearchSpace@Auckland2023

    … (CNA) detection. This study aimed to exemplify target-capture Next-Generation Sequencing data utility in bioinformatics-mediated sequence variant/SV/CNA detection, using a 1,138-gene cancer gene panel (CGP)/Immunoglobulin Heavy Locus (IGH) tiling array on paired germline/peripheral blood and …

    auckland-ms Repository record

  7. Exploring the specificity and mechanisms of siRNA-mediated gene silencing in mammalian cells

    Alemán, Lourdes MariaMassachusetts Institute of Technology2008

    … knockdown gene expression. siRNAs bind to their target sequence and guide transcript cleavage and subsequent degradation. This type of silencing is associated with equivalent levels of RNA and protein knockdown. siRNA-mediated knockdown was originally thought to be highly specific. However, the …

    mit Repository record

  8. Quantification of spray drift from aerial applications of pesticide

    Caldwell, Daniel MorganUniversity of Saskatchewan2007

    … spray was deposited in the measuring area. Total off-target movement of spray was significantly greater for Fine compared to Coarse sprays. Rotary and hydraulic atomizers, both producing Fine sprays, produced statistically similar off-target movement of sprays. Similarly, no significant …

    sask Repository record

  9. Discovery of Immunogenic Neo-peptides from Actionable RNA Fusion CD74-NRG1 for Developing Cancer Vaccines

    Rankothgedera, Sakuni VibodhaUniversity of Houston2024

    … in healthy cells, represents an attractive target for tumor-specific immunotherapy with minimal side effects. To evaluate the neoantigenic potential of CD74-NRG1, 36 peptides (9, 10, and 11 amino acids) derived from the fusion junction and wild-type sequences were tested for HLA binding …

    houston Repository record

  10. Interrogation of CRISPR-Cas targeting specificity for mammalian genome engineering

    Scott, David (David Arthur)Massachusetts Institute of Technology2017

    … we optimize the efficiency and characterize the targeting specificity of SpCas9 to ensure robust cleavage activity while minimizing off-target activity in human cells. We characterize SpCas9 mismatch tolerance between the guide RNA and target, and provide data-driven design software to guide the …

    mit Repository record

  11. NANOTECHNOLOGICAL APPROACHES FOR CANCER DIAGNOSIS, TREATMENT AND MANAGEMENT: IMPLEMENTATION OF FERRITIN PROTEIN NANOPARTICLES FOR TUMOR TARGETING

    SEVIERI, MARTAUniversità degli Studi di Milano2024

    … lack of specificity in hitting the therapeutic target, determining the onset of toxicity issues. In this context, Nanomedicine aims to make a decisive contribution. Nanoparticle (NPs)-based drug delivery systems can enhance the physicochemical properties of a wide variety of drugs used in …

    milano Repository record

  12. Epigenetic Determinants of CRISPR-Cas9 genotoxicity

    Stalker, EveUniversity of Cambridge2025

    … therapies, such as those using CRISPR-Cas9, offer promising treatment options for genetic disorders. However, they also present unique safety assessment challenges including detection of off-target effects and unintended genomic alterations. An unresearched area of these concerns involves the …

    cambridge Repository record

  13. Tackling Computational Challenges in High-Throughput RNA Interference Screening

    Zhong, Rui2016

    … as the first step to identifying novel drug targets or pathway components. Huge data sets are being generated, but computational challenges remain in data analysis and hit identification, which have become hurdles in HTS. These must be tackled before we can more accurately and precisely …

    utswmed Repository record

  14. Creating CRISPR-Cas9 genome edited iPSC lines to model a patient-specific mutation in mitochondrial disease

    Jalkanen, NelliHelsingin yliopisto2020

    … guide RNAs, and screening regions of potential off-target genome editing. Two genome-edited iPSC lines with the SARS2 c.1347 G>A mutation were successfully generated to model the patient mutation. The iPSC lines expressed pluripotency markers and contained no off-target genome editing and …

    helsinki Repository record

  15. Characterising Triflupromazine as a potential agent to treat glioblastoma multiforme

    Abualetham, Najib JeriesThe University of Edinburgh2025

    … strategies for GBM, hence drug repurposing offers the possibility of rediscovering new off target actions for FDA approved drugs. This is particularly pertinent in the absence of new drugs in clinical practice and the development of resistance in GBM. During my doctoral studies, I have taken …

    edinburgh Repository record

  16. Pharmacologically impeding glioblastoma tumour motility through simultaneous inhibition of aquaporin-1 and ion channels

    Varricchio, Alanah2023

    … challenge. I hypothesise that therapies which target cellular motility pathways could effectively slow tumour dispersal and widen the time window for administration of frontline treatments aimed at direct eradication of primary tumours. The array of signal transduction pathways that control …

    adelaide Repository record

  17. Haptic teleoperation of mobile manipulator systems using virtual fixtures.

    Wrock, MichaelUniversity of Ontario Institute of Technology2011

    … The three modes of operation are called near-target manipulation mode, off-target manipulation mode, and transportation mode. The system enters near-target manipulation mode only when close to a target of interest, and allows the operator to control the manipulator using velocity control. When …

    uoit Repository record

  18. Vibrotactile Guidance Cues For Target Identification

    Downs, Joshua

    … palmer versus dorsal surface of the hand, and targets appearing left versus right of center. Results suggest that tactile cues provided on the left side of the medial line of the hand afford moving the hand to the left, while tactile cues provided on the right side of the medial line afford …

    ucf

  19. Bioengineering functional polymer systems for glycan-based targeting and drug release

    Limqueco, Elaine Sze2025

    … therapeutic effect by enhancing delivery to the target cells or tissues, while curtailing adverse off-target effects. Existing approaches include liposomes, polymeric miscelle, protein-based nanoparticles, antibody-drug conjugates, dendrimers, and polymer drug conjugates. These systems provide …

    washington Repository record

  20. Designed Bond Cleavage Reactions for Next-Generation Therapeutics

    Vickraman Nair Bindu, UnnikrishnanUniversity of Cambridge2024

    … by developing novel prodrug systems that enable targeted activation in diseased tissues. The first project focuses on a metal-mediated amide bond-cleavage reaction from a pentenoic group by using Au salt (Na[AuCl4]) for prodrug activation in aqueous systems. Central to this strategy is a …

    cambridge Repository record

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