Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"oestrogen receptor"”.
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Characterising the role of TET2 in oestrogen receptor positive breast cancer
The activity of the transcription factor oestrogen receptor α (ER) drives tumour development and metastasis in ER positive (ER+) breast cancer. This subtype constitutes up to three-quarters of breast cancer cases, and treatments directly targeting ER are currently the standard of care. ER operates …
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A study of the regulation of oestrogen receptor alpha by tissue factor in breast cancer cells
… of breast cancer. In contrast, the expression of oestrogen receptor alpha (ERa) in breast cancer cells is associated with well differentiated breast tumours, with a low invasive potential. The aim of this study was to examine the influence of exogenous TF on the expression of ERa in breast cancer …
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The anti-cancer activity of a novel palladacycle, BTC2, in oestrogen receptor positive and triple negative breast cancers
… of drug resistance. Indeed, even though oestrogen receptor-positive breast cancers are known to respond to hormonal therapy, drug resistance is a common occurrence. Furthermore, triple negative breast cancers lack a specific therapeutic target, which has led to poor treatment outcomes. …
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Effects of Oestrogen Receptor Status of Women with Breast Cancer Treated with Tamoxifen at University Teaching Hospital and Cancer Diseases Hospital
… of this study was to determine the prevalence of oestrogen receptor-negative breast cancers at UTH and CDH and its impact on tamoxifen management. The specific objectives of the study were to determine the prevalence of oestrogen receptor negative of breast cancer patients; to determine other …
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Effects of Oestrogen Receptor Status of Women with Breast Cancer Treated with Tamoxifen at University Teaching Hospital and Cancer Diseases Hospital
… of this study was to determine the prevalence of oestrogen receptor-negative breast cancers at UTH and CDH and its impact on tamoxifen management. The specific objectives of the study were to determine the prevalence of oestrogen receptor negative of breast cancer patients; to determine other …
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The role of genetic factors in breast cancer aetiology
… such as grade, lymph node involvement,<br/>oestrogen receptor status and the presence of distant metastases.<br/><br/>We genotyped 206 SNPs across 30 candidate genes in 1001 patients. Association was performed<br/>using Cochran-Armitage trend test and 2-by-3 tables of disease by …
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Systems biology of breast cancer
… disease specific biomarkers. Among these, oestrogen receptor (ER) occupies a central role where overexpression is a prognostic indication for breast cancer. The cross-talk between the responsible contenders of ER-associated genes potentially play an important role in the disease aetiology. …
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The anti-cancer activity of extracts derived from millets and Kraalbos
… plant, Galenia africana, against the MCF-7 oestrogen receptor positive and the MDA-MB-231 triple negative breast cancer cell lines. The millet extracts tested were derived from Sorghum bicolor (Enforcer), Pennisetum glaucum (Babala) and Eragrostis tef (Tef) using both a reflux-based and a …
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SMARCB1 Maintains Lineage Fidelity in Clear Cell Renal Cell Carcinoma
… in the clinic is targeting the androgen receptor and the oestrogen receptor in prostate and breast cancer respectively. Despite the success of these therapies, the mechanisms that maintain lineage fidelity in advanced cancer clones, and whether lineage factor pathways could be exploited …
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Decision-making in older women with breast cancer: a mixed methods study
… of older women diagnosed with primary, operable, oestrogen receptor positive breast cancer and faced with a choice of surgery or primary endocrine therapy (PET). Research design and methods This exploratory, sequential mixed methods study comprised a critical review of the literature, qualitative …
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Phosphorylation of ERα and HIF-1α in breast cancer with focus on tamoxifen response and links to kinase activation
Anti-oestrogens are commonly used in adjuvant breast cancer treatment and for a long time tamoxifen has been the main endocrine treatment. Patients who are eligibly for endocrine treatment are selected by the tumour-specific expression of oestrogen receptor (ER) and approximately 70 % of all breast …
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Identification of proteins interacting with the human mismatch repair protein MLH1
… of c-MYC to the hormone binding domain of the oestrogen receptor was utilised. Elevated expression of c-MYC did not effect the mismatch specific binding complex activity in these cells as measured in EMSA experiments. However c-MYC overexpression utilising the Rat-1 cMYCERTM system was shown to …
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Characterisation of Androgen Receptor Variants in Breast Cancer and the Development of Thieno[2,3-b] Pyridines as Novel Anti-Cancer Compounds
In Breast Cancer(BCa), steroid receptors play a key role in the progression of the majority tumours. Oestrogen Receptor-α (ERα), for example,drives the growth of approximately 70% of tumours and is therefore a useful therapeutic target for this disease.Interestingly, the Androgen Receptor (AR) is …
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The Role of Androgen Receptor Signalling in Endocrine Resistant Breast Cancer
… sensitive and develop through the action of oestrogens, facilitated through the transcription factor Oestrogen Receptor alpha (ERα). Treatment for these patients usually involves endocrine therapies (Aromatase Inhibitors and antioestrogens), which are successful in many patients, but therapy …
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Graph Representation Learning to Study the Tumour Microenvironment
… I carry out a proof-of-concept study to predict oestrogen receptor (ER) status, a key clinical variable for breast cancer patients. The results suggest that MULTIPLAI successfully captures TME features with clinical importance. For the second case study of MULTIPLAI, I explore the relationship …
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The regulation of the oncogenic STAT transcription factors by the non receptor tyrosine kinase and Cdc42 effector ACK
… clinic. Through relationships with the androgen receptor in prostate cancer and the oestrogen receptor in breast cancer, ACK regulates transcriptional networks in disease. In this work, new roles for ACK in transcription, mediated by its relationship with the signal transducer and activators of …
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Effect of phytoestrogens on breast and prostate cancer cell lines – potential implications for bone metastasis
The effect of phytoestrogens on breast and prostate cancer cell lines – potential implications for bone preferential metastasis to bone Safaa Salman Mezban AL-Thamiree Abstract Many epidemiological studies indicate that diets rich in phytoestrogens (PE), especially soy and grain products, may be …
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Genetic and Epigenetic Characterisation of Breast Tumours
… The alterations in PIK3CA were associated with oestrogen receptor (ER) positivity, whereas PTEN predominantly was lost in ER-negative tumours. In Paper II, we analysed genomic aberrations at chromosome 11q13 in CCND1 (11q13.3)-amplified breast tumours and identified cores proximal and distal of …
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Cytochrome P450 mRNA profile in human breast cancer cell lines.
… of various compounds, both endogenous (e.g. oestrogen) and exogenous (e.g. tamoxifen). Intermediate P450 metabolites derived from oestrogen metabolism are associated with breast carcinogenesis. The main aims of this thesis were to firstly profile the cytochrome P450 and P450-regulatory …
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The Biology of Mantle Cell Lymphoma: Exploring the Gender Difference in Mantle Cell Lymphoma
… of lymphoma in females taking exogenous oestrogen. This aim of this thesis was to explore the gender difference observed in MCL. The study investigated the difference in the quantity of immune cells in the peripheral blood and lymph node biopsies of untreated male and female MCL patients. …
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