Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 95 for “"oestrogen"”.
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Characterising the role of TET2 in oestrogen receptor positive breast cancer
The activity of the transcription factor oestrogen receptor α (ER) drives tumour development and metastasis in ER positive (ER+) breast cancer. This subtype constitutes up to three-quarters of breast cancer cases, and treatments directly targeting ER are currently the standard of care. ER operates …
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Clinical and metabolic effects of the menopause and the role of replacement oestrogen therapy.
… the role of subsequent replacement exogenous oestrogen therapy. To this end pertinent clinical and laboratory studies were carried out. It is considered that the following contributions to knowledge have been made: 1. The symptoms and clinical signs directly related to endogenous oestrogen …
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The association between oestrogen, memory, cognition and mood in a male-to-female transsexual population
… demonstrated that gonadal hormones, including oestrogen, can influence memory and cognitive tasks that show sex differences in animals and humans. Beneficial effects of oestrogen on mood have also been reported in postmenopausal women in association with Oestrogen Replacement Therapy (ERT). …
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A study of the regulation of oestrogen receptor alpha by tissue factor in breast cancer cells
… of breast cancer. In contrast, the expression of oestrogen receptor alpha (ERa) in breast cancer cells is associated with well differentiated breast tumours, with a low invasive potential. The aim of this study was to examine the influence of exogenous TF on the expression of ERa in breast cancer …
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The anti-cancer activity of a novel palladacycle, BTC2, in oestrogen receptor positive and triple negative breast cancers
… of drug resistance. Indeed, even though oestrogen receptor-positive breast cancers are known to respond to hormonal therapy, drug resistance is a common occurrence. Furthermore, triple negative breast cancers lack a specific therapeutic target, which has led to poor treatment outcomes. …
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Effects of Oestrogen Receptor Status of Women with Breast Cancer Treated with Tamoxifen at University Teaching Hospital and Cancer Diseases Hospital
… of this study was to determine the prevalence of oestrogen receptor-negative breast cancers at UTH and CDH and its impact on tamoxifen management. The specific objectives of the study were to determine the prevalence of oestrogen receptor negative of breast cancer patients; to determine other …
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Effects of Oestrogen Receptor Status of Women with Breast Cancer Treated with Tamoxifen at University Teaching Hospital and Cancer Diseases Hospital
… of this study was to determine the prevalence of oestrogen receptor-negative breast cancers at UTH and CDH and its impact on tamoxifen management. The specific objectives of the study were to determine the prevalence of oestrogen receptor negative of breast cancer patients; to determine other …
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The effects of fluctuations in oestrogen and progesterone during the menstrual cycle on glucose homeostasis, energy balance, exercise and premenstrual syndrome
… such a greater understanding of the effects that oestrogen and progesterone may have on women's health and their potential long term consequences is required. This thesis reports evidence of three studies investigating the effects of oestrogen and progesterone during the menstrual cycle on glucose …
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ΜΕΛΕΤΗ ΣΥΜΜΕΤΟΧΗΣ ΤΩΝ ΝΤΟΠΑΜΙΝΕΡΓΙΚΩΝ ΝΕΥΡΩΝΩΝ ΣΤΗΝ ΑΡΝΗΤΙΚΗ ΠΑΛΙΝΔΡΟΜΗ ΡΥΘΜΙΣΗ ΤΩΝ ΓΟΝΑΔΟΤΡΟΦΙΝΩΝ ΜΕ ΟΙΣΤΡΟΓΟΝΑ
THE NEGATIVE FEEDBACK CONTROL OF OESTROGEN TO GONADOTROPIN SECRETION AND THE POSSIBILITY OF THE ACTIVATION OF DOPAMINERGIC NEURONS FOR ELICITING THIS OESTROGEN EFFECT HAS BEEN STUDIED IN 23 MENOPAUSE WOMEN. THE ADMINISTRATION OF OESTRADIOL BENZOATE (1 MGR I.M) RESULTED IN AN INITIAL DECLINE AT LH …
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The effect of reproductive hormones on muscle function in young and middle-aged females.
… varying hormonal status 2) establish the role of oestrogen in this weakness and 3) investigate the effectiveness of hormone replacement therapy (HRT) in maintaining muscle function. The reliability of an isokinetic dynamometer and a strain gauge assembly was examined initially to determine the …
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Characterisation of oestrogenic properties of Isoflavones derived from Millettia griffoniana Baill.: - Molecular mode of action and tissue selectivity
… (4-O-GIQ) were tested for potential oestrogenic activities in three different oestrogen receptor alpha (ERα) dependent assays, namely a recombinant yeast assay, a reporter gene assay based on stably transfected MCF-7 cells (MVLN cells) and the induction of alkaline phosphatase in …
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A new pathway in the induction of breast cancer
… neoplasia. Given the presence of putative oestrogen response elements (ERE) in its promoter, we assessed PBF regulation by oestrogen. PBF mRNA and protein expression were induced by both diethylstilbestrol and 17ß-estradiol in ER!-positive MCF-7 cells. Close analysis of the PBF promoter …
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ΣΥΜΒΟΛΗ ΣΤΟΝ ΚΑΘΟΡΙΣΜΟ ΤΗΣ ΕΛΑΧΙΣΤΗΣ ΔΡΑΣΤΙΚΗΣ ΔΟΣΕΩΣ ΟΙΣΤΡΟΓΟΝΩΝ ΣΤΟΝ CA ΠΡΟΣΤΑΤΟΥ
… TEST IN THE DETERMINATION OF THE RIGHT DOSES OF OESTROGEN IN THE MANAGEMENT OF PROSTATIC CARCINOMA WAS STUDIED. FOR THAT PURPOSE 48 PATIENTS WITH PROSTATIC CARCINOMA WERE STUDIED. A DOSE OF 100 MG LHRH WAS GIVENINTRAVENOUSLY AND THE LEVELS OF LH AND FSH IN BLOOD SERUM WERE MEASURED TO ALLOF THEM. …
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Bifidobacterial enzymic transformation of isoflavones, their bioavailability and effects on disease risk biomarkers in postmenopausal women
… to ovarian failure and subsequent diminishing oestrogen levels, are seeking natural alternatives to oestrogen and hormone replacement therapy due to its proposed adverse cancer-related effects. The main objectives of this study were to develop an isoflavone aglycone-enriched fermented soymilk …
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Identification and characterization of glial and neuronal cells in vitro and in bone marrow
… investigate the effects of the steroid hormone oestrogen on the growth of glial cells and (d) to investigate the presence of neuronal cell bodies in mammalian bone marrow using alternative approaches. Glial cells were grown for 20 days, supplemented with oestrogen after the 10th day. Control …
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The role of genetic factors in breast cancer aetiology
… such as grade, lymph node involvement,<br/>oestrogen receptor status and the presence of distant metastases.<br/><br/>We genotyped 206 SNPs across 30 candidate genes in 1001 patients. Association was performed<br/>using Cochran-Armitage trend test and 2-by-3 tables of disease by …
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Central mechanisms involved in the reproductive cycle of the ring dove (Streptopelia Risoria)
… and oviduct of incubating, non-incubating and oestrogen (E 2)-treated ring doves. Progesterone receptors were localized in similar regions of the brain in both sexes: the preoptic area (POA), nucleus preopticus paraventricularis magnocellularis (PPM), nucleus hypothalami lateralis (PLH), and in …
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Cytochrome P450 mRNA profile in human breast cancer cell lines.
… of various compounds, both endogenous (e.g. oestrogen) and exogenous (e.g. tamoxifen). Intermediate P450 metabolites derived from oestrogen metabolism are associated with breast carcinogenesis. The main aims of this thesis were to firstly profile the cytochrome P450 and P450-regulatory …
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