Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 75 for “"oesophageal cancer"”.
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Human Papillomaviruses in oesophageal cancer
Bibliography: p. 207-213.
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Differentially expressed genes in oesophageal cancer
Oesophageal cancer (OC) is a leading cause of cancer death in the black population in South Africa. The lifetime risk of the disease amongst black males is 1 in 59. High incidence areas are the Transkei, Ciskei and KwaZulu-Natal where it is responsible for over 45 of all malignancies. Cancer …
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Novel chemotherapeutic agents for oesophageal cancer
… currently used in the treatment of a variety of cancers, including oesophageal cancer. Although these agents have been part of our therapeutic repertoire for many years, there are several side effects that have been associated with their use in cancer therapy. Thus there is a need to develop …
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Proliferative and survival pathways in oesophageal cancer
Oesophageal squamous cell carcinoma (OSCC) is the 8th most common cancer worldwide with high incidence in areas that include China, Iran and South Africa. The current treatment available for OSCC does not significantly enhance patient survival. A better understanding of proliferative and survival …
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Risk factors for oesophageal cancer in Uruguay
… evaluate maté consumption as a risk factor for oesophageal cancer and to further evaluate the role of quantity and temperature in order to assess whether the effect is related to the carcinogenicity of the plant or the high temperature at which maté is consumed. In addition the effect of diet, …
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Altered protein expression patterns in oesophageal cancer
Oesophageal squamous cell carcinoma presents a significant health burden in South Africa. It is one of the most common causes of cancer-related mortality of South African black males, as a result of its asymptomatic progression leading to late diagnosis and poor prognosis. The aim of this study was …
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Family and tumour studies in breast and oesophageal cancer
This study focussed on two areas in the field of cancer susceptibility. The initial area was the genetic analysis of a recently mapped breast cancer susceptibility locus, BRCAl, in a number of breast and breast-ovarian cancer families. In the largest of the ICRF families studied (BOV3), linkage to …
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Triage-driven diagnosis for early detection of oesophageal cancer
… my work to advance the early detection of oesophageal adenocarcinoma by investigating translational aspects of a minimally invasive oesophageal cell sampling technology for the detection of Barrett oesophagus. Most oesophageal adenocarcinoma patients present with advanced disease, requiring …
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Epidemiology of oesophageal cancer at Groote Schuur Hospital : a case control study
… collected demographic information on women with oesophageal cancer being treated at Groote Schuur Hospital in Cape Twon, South Africa. The data formed part of a general cancer database in shich cases of cancer confirmed by histopathology were collected. The majority of patients originated from …
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Modulating ADAM-10 activity and expression in cervical and oesophageal cancer cells
… linked a range of ADAMs, which include ADAM10 to cancer development and progression. Research in our laboratory found endogenous ADAM10 levels to be higher in both oesophageal and cervical cancer cell lines. Reports in the literature have highlighted a correlation between high levels of ADAM10 …
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Risk factors for oesophageal cancer in the Eastern Cape Province of South Africa
… medicinal wild plants on the risk of developing oesophageal cancer (OC) among residents of the Eastern Cape Province of South Africa. The study was conducted on 670 incident cases (98/% response rate) and 1188 controls (96/% response rate) attending either of the three major referral hospitals in …
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Molecular mechanisms involved in the anticancer activity of BISPMB in oesophageal cancer cells
… 12 times more active at inhibiting the growth of oesophageal squamous cell carcinoma WHCO1 cells and displays selectivity for cancer cells over normal cells. BisPMB is therefore attractive as a potential cancer therapeutic. In this study, bisPMB was found to inhibit WHCO1 cancer cell proliferation …
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The chromatographic determination of fusarium toxins in maize associated with human oesophageal cancer
… Transkeian maize samples associated with human oesophageal cancer-risk.
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Early detection of oesophageal cancer based on colour appearance and colour-based data augmentation
Oesophagus cancer is the 9th most common cancer and the 6th leading cause of cancer-related death. Globally, the estimated number of new cases was 572 000, of which approximately 509 000 persons died from oesophageal cancer in 2018. While the overall five-year survival rate of oesophagus cancer is …
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ROLES OF INOSITOL DIPHOSPHATES IN DNA REPAIR AND EFFECTS OF ASPIRIN ANALOGUES ON OESOPHAGEAL CANCER
… InsP8 synthesis was observed to be via 5-InsP7. Oesophageal cancer is considered as one of the deadliest cancers worldwide because of its aggressive nature and low survival rate. Epidemiologic studies have shown that low-dose daily intake of aspirin can decrease the incidence of oesophageal …
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Medications, sex hormones and reproductive factors in relation to gastro-oesophageal cancer risk and survival
Gastro-oesophageal cancer is a major health problem. The overall objectives of this thesis were to investigate novel risk factors for gastro-oesophageal cancer risk and progression, in particular focusing on commonly used medications, sex hormones, hormonal and reproductive factors.<br/><br/>In …
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Deep Learning in Oesophageal Cancer Development: Integrating Multi-Stain Histopathology Images of the Capsule Sponge
… condition that increases the risk of oesophageal adenocarcinoma (OAC). Surveillance relies on endoscopy with random biopsies, a costly and invasive procedure that limits population-scale feasibility. The capsule sponge, a pan- oesophageal cell collection device, has emerged as a …
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Deep learning on whole-slide images for early detection and risk prediction of oesophageal cancer
… progressing from Barrett’s oesophagus (BE) to oesophageal adenocarcinoma (EAC) earlier and more accurately using data from a minimally-invasive cell collection device. It also introduces a new software library for efficiently handling computational pathology tasks. Oesophageal adenocarcinoma is …
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An investigation into the molecular mechanisms induced by derivatives of natural products in oesophageal cancer
Current chemotherapies for oesophageal cancer display poor efficacy and tolerability, highlighting an unmet need for novel chemotherapeutic agents. Artemisinin derivatives, currently used to treat malaria, were recently shown to possess potent anticancer activity. This study investigated the …
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The role of human papillomavirus (HPV) E6 proteins as a risk factor for oesophageal cancer
Oesophageal squamous cell carcinoma (OSCC) is a major cancer in South Africa, affecting mainly black males. Several risk factors for OSCC have been reported but this study focuses on the role of human papilloma virus (HPV) in the development of OSCC. HPV is a well-known risk factor for cervical …
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