Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"oesophageal adenocarcinoma"”.
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A role for iron in oesophageal adenocarcinoma
In Western populations the incidence of oesophageal adenocarcinoma (OAC) is increasing greater than any other malignant disease. Increasing epidemiological and experimental evidence associates iron with OAC. Our understanding of iron physiology has increased enormously in recent years due to the …
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Clonal Dynamics in Barrett's Oesophagus and Oesophageal Adenocarcinoma
Introduction Outcomes in oesophageal adenocarcinoma (OAC) are poor, largely driven by most patients being diagnosed at a late stage. OAC has a metaplastic pre-cursor lesion, Barrett’s oesophagus (BO), which can be monitored and effectively treated if dysplasia develops. Screening for BO could …
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Elucidating TRPA1 Ion Channel Aberrations in Oesophageal Adenocarcinoma.
Oesophageal adenocarcinoma (OAC) is the 14th most common cancer, accounting for 5% of cancer mortalities in the UK. The genomic landscape of OAC is driven by structural variations and is characterised by high mutation burden. Although recurrent mutations are observed in only few genes, we have …
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Biomarkers of Progression from Barrett's Oesophagus to Oesophageal Adenocarcinoma
… oesophagus (BO) is a pre-malignant condition for oesophageal adenocarcinoma (OAC) [1], the incidence rate of which has been rising dramatically over the last four decades in the western world [2, 3]. Survival of an OAC affliction is poor, and one of the ways to improve this would be by focusing on …
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Epidemiological risk factors, related biomarkers and oesophageal adenocarcinoma survival
The demographics of oesophageal cancer have changed dramatically over the last 30 years. Oesophageal squamous cell carcinoma remains the predominant subtype worldwide, but in the western world the incidence of oesophageal adenocarcinoma has surpassed that of oesophageal squamous cell carcinoma and …
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Identification of targetable mediators of resistance to chemotherapy in oesophageal adenocarcinoma
The incidence of Oesophageal Adenocarcinoma (OAC) has risen six-fold in the western world in the last forty years but response rates to chemotherapy are low and survival is poor. Increased molecular understanding of this heterogeneous disease is needed to overcome resistance to chemotherapy and …
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Resolving the evolution of Oesophageal Adenocarcinoma using spatial and temporal sampling
Introduction Oesophageal adenocarcinoma (OAC) remains a poor prognosis cancer type. The pre-malignant lesion for this type of cancer is called Barrett’s Oesophagus (BO), which has two subtypes, Gastric Metaplasia (GM) and Intestinal Metaplasia with GM (IM). Both BO and OAC are genetically …
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An Investigation of Mutational Signatures in the Evolution of Oesophageal adenocarcinoma
… of Mutational Signatures in the Evolution of Oesophageal adenocarcinoma Sujath Abbas Oesophageal adenocarcinoma (OAC) remains a public health challenge with dismal survival rates and increasing incidence. This PhD study aimed to investigate how mutational processes act across different stages …
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Investigating the origins of polyploidy in Barretts oesophagus and oesophageal adenocarcinoma
… of polyploidy in Barrett’s oesophagus and Oesophageal adenocarcinoma. Oesophageal adenocarcinoma (OEAC) is preceded by the condition Barrett’s oesophagus (BE), in which the stratified squamous mucosa of the oesophagus becomes damaged from exposure to stomach acid, resulting in a …
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A pathways-based approach identifying determinants of drug resistance in oesophageal adenocarcinoma
Introduction: <br/>Five-year survival rates for oesophageal adenocarcinoma (OAC) remain poor at approximately 15%. The development of drug-resistance limits the effectiveness of current chemotherapies, with less than 20% of patients experiencing complete pathological response, so the discovery of …
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Driver genes, mutational signatures and the timing of mutations in oesophageal adenocarcinoma
The development of oesophageal adenocarcinoma (OAC) from Barrett’s oesophagus provides an excellent model of the step-wise progression of malignancy. This process is strongly associated with the reflux of stomach contents into the oesophagus. However the exact mechanism by which low pH and bile …
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Integrating Epidemiological and Genomic Factors to Inform Outcomes in Barrett’s Oesophagus and Oesophageal Adenocarcinoma
The incidence of oesophageal adenocarcinoma (OAC) has rapidly increased, and its prognosis remains poor. Barrett’s oesophagus (BO) is considered the precursor to OAC, however, BO is not apparent adjacent to tumour in nearly half of OAC patients. We have previously demonstrated that patients with …
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Multi-omic characterisation of Barrett’s oesophagus reveals a molecular continuum in the progression to oesophageal adenocarcinoma
… is the main risk factor for the development of oesophageal adenocarcinoma (OAC) yet only 0.4%/year of non-dysplastic (ND) BE cases progress to cancer (Bhat et al., 2011). In this thesis I present the first comprehensive, multi-omics study comparing indolent, non-progressors with those who …
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A Compendium of Genetic Drivers for Oesophageal Adenocarcinoma defines Prognostic and Therapeutic Biomarkers for use in the Clinic
Background: Oesophageal adenocarcinoma (OAC) is a poor-prognosis cancer type with rapidly rising incidence. Understanding of the genetic events driving OAC development is limited, and there are few molecular biomarkers for prognostication or therapeutics. This study aimed to use a large cohort of …
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The Use of 2D and 3D Models to Study Competition in the Context of Barrett’s Oesophagus and Oesophageal Adenocarcinoma
**Introduction**: Oesophageal adenocarcinoma (OAC) is a cancer with poor five-year survival which is mainly due to its late diagnosis. OAC develops through an identifiable pre-cursor stage, Barrett’s Oesophagus (BO). BO can progress via the accumulation of further genetic and morphological changes …
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Characterisation of Copy Number Changes in the Progression of Barrett’s Oesophagus
… The main risk factor for the development of oesophageal adenocarcinoma is Barrett’s oesophagus (BE). To diagnose those patients who will progress to cancer early to improve the dismal survival rate of oesophageal adenocarcinoma, patients with BE undergo regular endoscopic surveillance. The …
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Upper gastrointestinal adenocarcinoma: associations with gastric secretory function and gender
Gastric and oesophageal cancers were responsible for more than one million deaths in 2002. Although global incidence of gastric cancer is decreasing, this malignancy is still the fourth most common cause of cancer worldwide. The incidence of oesophageal adenocarcinoma is rising rapidly, three-fold …
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Triage-driven diagnosis for early detection of oesophageal cancer
… my work to advance the early detection of oesophageal adenocarcinoma by investigating translational aspects of a minimally invasive oesophageal cell sampling technology for the detection of Barrett oesophagus. Most oesophageal adenocarcinoma patients present with advanced disease, requiring …
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Deep learning on whole-slide images for early detection and risk prediction of oesophageal cancer
… progressing from Barrett’s oesophagus (BE) to oesophageal adenocarcinoma (EAC) earlier and more accurately using data from a minimally-invasive cell collection device. It also introduces a new software library for efficiently handling computational pathology tasks. Oesophageal adenocarcinoma is …
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