Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 175 for “"oesophageal"”.
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Human Papillomaviruses in oesophageal cancer
Bibliography: p. 207-213.
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Reconstructing Chromothriptic Chromosomes in Oesophageal Adenocarcinomas
… has been seen in up to 32% of cases of oesophageal adenocarcinomas. Therefore, patient-derived oesophageal adenocarcinoma organoids with evidence of chromothripsis restricted to one allele were used to better understand how the genome is regulated. Complex regions of structural variation …
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Differentially expressed genes in oesophageal cancer
Oesophageal cancer (OC) is a leading cause of cancer death in the black population in South Africa. The lifetime risk of the disease amongst black males is 1 in 59. High incidence areas are the Transkei, Ciskei and KwaZulu-Natal where it is responsible for over 45 of all malignancies. Cancer …
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Aspects of paediatric gastro oesophageal scintigraphy
… foregut motility in paediatric patients; notably oesophageal transit during swallowing, gastro oesophageal reflux (GOR) and stomach emptying as measured by the gastric contents 30 and 120 minutes after deglutition of liquid. Relevant anatomy, physiology, pathophysiology and non-radioisotopic …
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Novel chemotherapeutic agents for oesophageal cancer
… the treatment of a variety of cancers, including oesophageal cancer. Although these agents have been part of our therapeutic repertoire for many years, there are several side effects that have been associated with their use in cancer therapy. Thus there is a need to develop novel chemotherapeutic …
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Proliferative and survival pathways in oesophageal cancer
Oesophageal squamous cell carcinoma (OSCC) is the 8th most common cancer worldwide with high incidence in areas that include China, Iran and South Africa. The current treatment available for OSCC does not significantly enhance patient survival. A better understanding of proliferative and survival …
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A role for iron in oesophageal adenocarcinoma
In Western populations the incidence of oesophageal adenocarcinoma (OAC) is increasing greater than any other malignant disease. Increasing epidemiological and experimental evidence associates iron with OAC. Our understanding of iron physiology has increased enormously in recent years due to the …
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Risk factors for oesophageal cancer in Uruguay
… evaluate maté consumption as a risk factor for oesophageal cancer and to further evaluate the role of quantity and temperature in order to assess whether the effect is related to the carcinogenicity of the plant or the high temperature at which maté is consumed. In addition the effect of diet, …
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Altered protein expression patterns in oesophageal cancer
Oesophageal squamous cell carcinoma presents a significant health burden in South Africa. It is one of the most common causes of cancer-related mortality of South African black males, as a result of its asymptomatic progression leading to late diagnosis and poor prognosis. The aim of this study was …
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Exploring Gastro-oesophageal Reflux in Infants and Children
Background: Gastro-oesophageal reflux in babies, young children and teenagers is a frequent cause of symptoms, parental concern and paediatric referrals. Sequelae can include failure to thrive, haematemesis, and recurrent aspiration. Current conservative management includes reassurance, feeding …
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Clonal Dynamics in Barrett's Oesophagus and Oesophageal Adenocarcinoma
Introduction Outcomes in oesophageal adenocarcinoma (OAC) are poor, largely driven by most patients being diagnosed at a late stage. OAC has a metaplastic pre-cursor lesion, Barrett’s oesophagus (BO), which can be monitored and effectively treated if dysplasia develops. Screening for BO could …
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Elucidating TRPA1 Ion Channel Aberrations in Oesophageal Adenocarcinoma.
Oesophageal adenocarcinoma (OAC) is the 14th most common cancer, accounting for 5% of cancer mortalities in the UK. The genomic landscape of OAC is driven by structural variations and is characterised by high mutation burden. Although recurrent mutations are observed in only few genes, we have …
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Characterization of ADAM10 in cervical and oesophageal cancers
… very little is known of its role in cervical and oesophageal cancer. The aim of this study was to investigate the endogenous expression of ADAM10 in cervical and oesophageal patient material and representative cell lines.
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Family and tumour studies in breast and oesophageal cancer
… a pedigree without associated susceptibility to oesophageal cancer. In the pedigrees with a striking association between focal NEPPK and oesophageal cancer susceptibility, the region harbouring this disease locus (TOC) was refined to a lcMregion on 17q24-25.
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Biomarkers of Progression from Barrett's Oesophagus to Oesophageal Adenocarcinoma
… oesophagus (BO) is a pre-malignant condition for oesophageal adenocarcinoma (OAC) [1], the incidence rate of which has been rising dramatically over the last four decades in the western world [2, 3]. Survival of an OAC affliction is poor, and one of the ways to improve this would be by focusing on …
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Epidemiological risk factors, related biomarkers and oesophageal adenocarcinoma survival
The demographics of oesophageal cancer have changed dramatically over the last 30 years. Oesophageal squamous cell carcinoma remains the predominant subtype worldwide, but in the western world the incidence of oesophageal adenocarcinoma has surpassed that of oesophageal squamous cell carcinoma and …
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Triage-driven diagnosis for early detection of oesophageal cancer
… my work to advance the early detection of oesophageal adenocarcinoma by investigating translational aspects of a minimally invasive oesophageal cell sampling technology for the detection of Barrett oesophagus. Most oesophageal adenocarcinoma patients present with advanced disease, requiring …
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Helicobacter pylori and its Association with Gastric and Oesophageal Carcinomas
… and the development of gastric and oesophageal carcinomas. Nested case-control studies were performed in the Malmö Preventive Medicine cohort consisting of 32,906 subjects. Tumour cases were identified by the Swedish National Cancer Registry. H. pylori infection was identified …
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