Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"odorant receptors"”.
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Odorant receptors: regulation, signaling, and expression
… binding of odorous ligands to G protein-coupled odorant receptors, resulting in the activation of G protein and second messengers that culminates in the generation of action potentials to relay this signal to the brain for odor recognition. This signaling cascade comprises the primary olfactory …
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Concentration-dependent recruitment of mammalian odorant receptors
… of comprehensively identified sets of activated odorant receptors (ORs) across an odorant concentration range inside freely behaving animals. In mammals, this has recently become feasible with high-throughput sequencing-based methods that identify populations of odorant activated ORs in vivo. In …
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Modulation and Ligand Selectivity of Mammalian Odorant Receptors
… of smell starts with the activation of odorant receptors (ORs) by volatile molecules in the environment. Mammalian genomes typically encode large numbers of ORs, with approximately 400 intact ORs in human and more than 1000 in mouse. Central to the question of how olfactory stimuli are …
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The Role of Drosophila Odorant Receptors in Odor Coding
… research, the expression patterns of fly's 62 odorant receptors (ORs) were largely unknown. I set out to understand the rules of connectivity of olfactory sensory neurons and the resulting properties of olfactory circuit. Consequently, we assembled maps of the olfactory neuron projections in …
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Mosquito Odorant Receptors: C-terminal Motifs, Subfamily Expansion, and Function
… olfactory signaling components such as mosquito odorant receptors. This hypothesis is supported by several lines of evidence including the highly divergent and lineage-specific nature of this receptor family. Likely these differences are subtle and will be identified in highly focused studies. …
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Evolution of the Gr family of gustatory and odorant receptors in mosquitoes
… typically revolve around taste and smell. Of the receptors involved in chemoperception, the gustatory receptor (Gr) protein family comprises most of the diversity in the insect chemoreceptor superfamily, including within it not only taste receptors, but select olfactory receptors as well. Manual …
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The Guidance of Olfactory Sensory Axons to Identifiable Protoglomeruli in the Larval Zebrafish Olfactory Bulb
… zebrafish lines in which neurons expressing odorant receptors along with the olfactory marker protein (OMP), V2R vomeronasal receptors along with the transient receptor potential channel2 (TRPC2) or the odorant receptor OR111-7 are selectively labeled. OMP and TRPC2 expressing neurons …
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Mosquito odor receptor gene targets to alter vector host choice
… meal. Mosquitoes detect semiochemicals through odorant receptors, each of which interact with specific odorants. Differences in feeding behaviors have significant consequences for the vectorial capacity of Anopheles mosquitoes. Mosquitoes in the genus Anopheles vector the pathogens causing human …
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Chemoreceptors From the Hawk Moth Manduca Sexta L
… I cloned and characterized four M. sexta chemoreceptors. Differential screening of a male antennal cDNA library before the publication of the Drosophila melanogaster genome yielded one G coupled-protein receptor that had no matches in Genbank databases and the results of RT-PCR and quantitative …
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Autosomal random asynchronous replication is analogous to X-chromosome inactivation
… well as a number of autosomal genes, including odorant receptors, immunoglobulins, T-cell receptors, interleukins, natural killer-cell receptors, and pheromone receptors. Random asynchronous replication of DNA in S-phase represents an epigenetic mark that often parallels monoallelic expression. …
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CRISPR/CASTE: Functional Genomic Studies of the Major Evolutionary Innovations of Ants
… an important class of chemosensory proteins, the odorant receptors, in insects. I created orco mutant ants and found that they have striking deficiencies in their social behavior and fitness, including an inability to nest with other ants or follow chemical pheromone trails and severely reduced …
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Chemosensory gene expression analysis in the argentine ant, linepithema humile
… of a subset of chemosensory genes, including odorant receptors (Ors) and odorant binding proteins (OBPs), in the invasive Argentine ant, Linepithema humile. Fragments of two Ors were identified from a whole ant EST project, which suggested their potential importance in Argentine ant ecology. …
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The Roles of Wnt5 and the Drl Receptor in the Development of the Drosophila Olfactory System
… olfactory receptor neurons expressing the same odorant receptors converge their axons precisely onto a specific set of projection neuron dendrites, forming glomeruli in stereotypic positions of the antennal lobe. Although many studies have revealed the crucial role of projection neurons in the …
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Cells that Kill: The Chemosensory Cell Types of Aedes aegypti Mosquitoes
… research following the cloning of the first odorant receptors in1991 has shown that each mouse olfactory sensory neuron (OSN) expresses a single odorant receptor. Early work in Drosophila melanogaster flies reported a similar organization, although some key differences were noted. Insects …
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Functional characterization of olfactory receptors and molecular species identification of vector mosquitoes.
… that are embedded with ligand gated olfactory receptors. Mosquito sensory receptors consist of three main families comprising odorant receptors (Ors), ionotropic receptors (Irs), and gustatory receptors (Grs). Detection of semiochemicals via olfactory receptors modulates behaviors including …
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Regulation of Polarized Protein Transport to Axons, Dendrites, and Sensory Cilia in Caeborhabditis Elegans Neurons
… including ion channels, neurotransmitter receptors, synaptic vesicles, and signaling proteins. Yet, despite the significance of asymmetric protein transport in neuronal polarity, the molecules and mechanisms that direct polarized transport to axons, dendrites and cilia in neurons are only …
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Chemical communication in cerambycid beetles and the molecular basis of olfaction
… their models. Finally, I present research on the odorant receptors (Ors) of cerambycids, which are members of a family of receptors responsible for detecting volatile chemicals at the molecular level. I sequenced 57 Ors from RNA extracted from antennae of male and female M. caryae, and tested …
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COMPARATIVE GENOMICS OF CHEMOSENSORY GENE FAMILIES AMONG MEMBERS OF THE HELIOTHINAE
… curated two chemosensory gene families, the odorant receptors (ORs) and odorant binding proteins (OBPs), in C. virescens. In total, I identified 80 ORs, 1 Orco and 49 OBPs. Three types of OBPs were identified according to the number and positions of conserved cysteine residues: 34 classic …
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Getting at the Surface: A Promoter and Coding Sequence Characterization of an Odorant Receptor
<p>Odorant receptors (ORs) are expressed by mature olfactory sensory neurons (OSNs), in a monogenic and monoallelic fashion (singular gene choice). It has been repeatedly published that the singular expression of ORs is a consequence of epigenetic regulation. The model invokes the depositing of …
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Design and fabrication of electron energy filters for room temperature inelastic electron tunneling spectroscopy
… of biological olfaction postulates that the odorant detectors inside a nose recognize an odorant's vibrations via inelastic electron tunneling (Turin, 1996). However, a biological system works at room temperature but conventional IET spectroscopy requires cryogenic temperatures. Thus posing …
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