Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"odorant receptor"”.
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Employing High Probability Gene Choice Elements to Understand Singular Odorant Receptor Expression
… olfactory sensory neurons (OSNs), which express odorant receptors (ORs) that bind to chemical odors in the environment. In order to increase specificity and sensitivity, an essential property in olfaction is for each OSN to express an OR in a monogenic and monoallelic fashion. Out of a large …
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Getting at the Surface: A Promoter and Coding Sequence Characterization of an Odorant Receptor
<p>Odorant receptors (ORs) are expressed by mature olfactory sensory neurons (OSNs), in a monogenic and monoallelic fashion (singular gene choice). It has been repeatedly published that the singular expression of ORs is a consequence of epigenetic regulation. The model invokes the depositing of …
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Odorant receptors: regulation, signaling, and expression
… binding of odorous ligands to G protein-coupled odorant receptors, resulting in the activation of G protein and second messengers that culminates in the generation of action potentials to relay this signal to the brain for odor recognition. This signaling cascade comprises the primary olfactory …
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Odorant Responses and Courtship Behaviors Influenced by at4 Neurons in Drosophila
… specificity and function. Using a combination of odorant receptor mutant analysis, single sensillum electrophysiology and optogenetics, I have examined the chemical tuning and behavioral consequences of the three at4 olfactory neuron classes. My results indicate that one class, Or65abc neurons, …
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Mosquito Odorant Receptors: C-terminal Motifs, Subfamily Expansion, and Function
… olfactory signaling components such as mosquito odorant receptors. This hypothesis is supported by several lines of evidence including the highly divergent and lineage-specific nature of this receptor family. Likely these differences are subtle and will be identified in highly focused studies. …
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Cracking the Odor Code: Molecular and Cellular Deconstruction of the Olfactory Circuit of Drosophila Larvae
… of larval odor coding. First, the larval odorant receptor (OR) repertoire was characterized. ORs define the olfactory receptive range of an animal. Each of the 21 larval olfactory sensory neurons (OSNs) expresses one or rarely two ORs, along with the highly conserved olfactory co-receptor …
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Cloning, stem cells and epigenetic reprogramming after nuclear transfer
… whether generation of synaptic diversity or odorant receptor choice, are mediated by genetic as well as epigenetic events.
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Molecular evolution of a superfamily of chemoreceptors in Musca domestica and Ceratitis capitata
… of Drosophila retain higher diversity of chemoreceptor genes as compared to the rapid loss characteristic of specialists, but the same may not be true of other dipterans. Here the odorant receptor subfamily in M. domestica and the gustatory receptor subfamily in C. capitata were annotated, and …
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Analysis of the Molecular Mechanisms of Drosophila Antennal Lobe Development
In Drosophila or mice, the axons of olfactory receptor neurons (ORNs) bearing the same odorant receptor converge on one specific glomerulus in the antennal lobe or olfactory bulb, where they synapse with the dendrites of the postsynaptic cells, projection neurons (PNs) or mitral cells. Mutation in …
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Mechanisms of Volatile Odorant Detection and Corresponding Behavioral Effects in Drosophila
… insect repellents, and food source-derived odorants by primary sensory neurons in Drosophila and the corresponding behaviors generated by these stimuli. To date, the only known volatile pheromone in Drosophila is the male-specific hydrocarbon 11-cis-vaccenyl acetate (cVA). I took a genetic …
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The Guidance of Olfactory Sensory Axons to Identifiable Protoglomeruli in the Larval Zebrafish Olfactory Bulb
… zebrafish lines in which neurons expressing odorant receptors along with the olfactory marker protein (OMP), V2R vomeronasal receptors along with the transient receptor potential channel2 (TRPC2) or the odorant receptor OR111-7 are selectively labeled. OMP and TRPC2 expressing neurons …
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Insect Host Seeking: Investigations into the Molecular Mechanisms of Chemosensation
… involved in insect chemosensation. The atypical odorant receptor gene, Or83b, is co-expressed with other ORs in most olfactory sensory neurons (OSNs) of the Drosophila antenna. OR83b acts as a generic heterodimeric partner for other ORs coupling them to the ciliary trafficking machinery, which is …
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From Microarrays to Behavior: Genes Controlled by Feeding State in Mosquitoes and Flies
… to nutritional state. We found that two odorant receptor genes are significantly regulated by blood-feeding. These are therefore candidate receptors for ligands that are important for host-seeking. We then extended our studies to Drosophila with the goal of identifying novel regulators of …
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Multi-Modal Effects of the Repellent Deet Across Protostomia
… the arm, while mutant mosquitoes that lack the odorant receptor co-receptor (orco), approach the arm, but rarely bite. We investigated this orco-independent DEET repellency in Ae. aegypti and found that these mosquitoes can sense DEET with their tarsi as well as their proboscis. The tarsi are …
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Modulation and Ligand Selectivity of Mammalian Odorant Receptors
… of smell starts with the activation of odorant receptors (ORs) by volatile molecules in the environment. Mammalian genomes typically encode large numbers of ORs, with approximately 400 intact ORs in human and more than 1000 in mouse. Central to the question of how olfactory stimuli are …
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Cells that Kill: The Chemosensory Cell Types of Aedes aegypti Mosquitoes
… research following the cloning of the first odorant receptors in1991 has shown that each mouse olfactory sensory neuron (OSN) expresses a single odorant receptor. Early work in Drosophila melanogaster flies reported a similar organization, although some key differences were noted. Insects …
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Investigation of Age Related Differences in the Rewiring of P2-Olfactory Receptor Neurons
Olfactory receptor neurons (ORNs) maintain the ability to regenerate. These neurons reside in the olfactory epithelium and project axons that connect to the olfactory bulbs. Despite the diffuse distribution of ORNs in the olfactory epithelium, they converge at discrete glomeruli in the olfactory …
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Concentration-dependent recruitment of mammalian odorant receptors
… of comprehensively identified sets of activated odorant receptors (ORs) across an odorant concentration range inside freely behaving animals. In mammals, this has recently become feasible with high-throughput sequencing-based methods that identify populations of odorant activated ORs in vivo. In …
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Chemical communication in cerambycid beetles and the molecular basis of olfaction
… their models. Finally, I present research on the odorant receptors (Ors) of cerambycids, which are members of a family of receptors responsible for detecting volatile chemicals at the molecular level. I sequenced 57 Ors from RNA extracted from antennae of male and female M. caryae, and tested …
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Mapping the Brain of the Clonal Raider Ant: Integrating Behavior, Neuroanatomy and Connectomics
… of the ant and massive expansion of odorant receptor genes and olfactory glomeruli in the antennal lobe compared to other insects, our initial reconstruction efforts focus on understanding the wiring logic of the ant olfactory system. In summary, this thesis represents early steps …