Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"ocular bioavailability"”.
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Design and Development of Solid Lipid Nanoparticles for Ocular Delivery of Acyclovir
Background and aim: Ocular infections caused by Herpes keratitis remain the leading cause of infectious blindness in the developed world and there is a need for the development of a novel drug delivery system to improve treatment options. The complex structure of the eye poses several challenges …
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Development of Topical Ophthalmic In Situ Gel-Forming Estradiol Delivery System Intended for the Prevention of Age-Related Cataracts
… that is stable and safe; 2) to determine if ocular estrogen formulation was more effective than systemic therapy in inducing cataracts and activating estrogen-regulated genes in ERδ3 mice, while minimizing systemic side effects in the estrogen-responsive uterus; 3) to determine ocular safety …
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Biopharmaceutical approaches for improved drug delivery across ocular barriers
… protective actions drastically diminish the ocular bioavailability of drugs. The corneal epithelium acts as a major barrier towards the permeation of hydrophilic agents, whereas poor aqueous solubility presents a formulation challenge for lipophilic compounds. Additionally, P-glycoprotein …
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Stereoisomeric Prodrugs to Improve Ocular And Oral Absorption of Prednisolone
… D-valine-L-valine-prednisolone (DLP) to improve ocular and oral absorption of prednisolone. These prodrugs have been examined for their interaction with various influx and efflux transporters commonly expressed on corneal and intestinal epithelium. They have been evaluated for their …
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Photosensitizer Loaded Contact Lenses As An Externally Stimulated Ophthalmic Drug Delivery System
… is primarily associated with the treatment of ocular diseases. 90% of the ophthalmic dosage forms are given topically. However, following the topical route, only 5% ocular bioavailability is achieved. The aim of my work is to address the problems associated with the conventional topical …
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Development and Characterization of Fluocinolone Acetonide Loaded Nanosized Lipid Carriers for Ocular Delivery via Subconjunctival Route: Synergistic Effect of Vitamin a Palmitate
… the delivery of therapeutic molecules into deep ocular compartments has always been a challenging task. In this regard, the main objective of our current investigation was to develop and evaluate the fluocinolone acetonide (FA) loaded nanostructure lipid carrier (FA-NLC) in situ gel for improved …
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Lipid Nanoparticles as Tools for the Administration of Active Natural Products Aimed to the Treatment of Nervous System Disorders
… the drug stability, in order to achieve good bioavailability in the brain. The best strategies to realize sSLN, suitable for parenteral administration, were to coat the CUR-SLN surface with hydrophilic polymer PEG (CUR-pSLN), while the AST-SLN with surfactant polysorbate 80 (AST-p80SLN). …
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Ocular pharmacokinetics and efficacy of various amino acid and dipeptide prodrugs of ganciclovir
… associated with thymidine analogues are their ocular and systemic toxicities in long term usage. Even though GCV and ACV have good efficacies against HSV, their limited solubility, poor corneal absorption and diminished ocular bioavailability limits their effectiveness. Ointments and gels are …
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Topical Clear Aqueous Nanomicellar Formulations For Anterior And Posterior Ocular Drug Delivery
… hydrophobic drugs were successfully developed. Ocular bioavailability and pharmacokinetic studies demonstrated a very high drug levels in retina-choroid (place of drug action) with a negligible drug partitioning into lens and vitreous humor. These results suggest that drug and/or NMFs cannot …
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Biopharmaceutic and Pharmacokinetic Evaluation of Hesperidin and Hesperetin for Ocular Delivery
… characteristics of hesperidin and hesperetin for ocular delivery, especially with respect to the distribution of these compounds to the posterior segment of the eye. Hesperidin and hesperetin were found to be water insoluble compounds. Although they demonstrated good permeability across the ocular …
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TGF-beta 1 PATHWAY AND AGE-RELATED MACULAR DEGENERATION
… 1 (TGF-beta 1) was developed; and TGF-beta 1 ocular pharmacokinetics profile was assessed. Methods: Sprague-Dawley male rats were used. Human Abeta 1-42 oligomers were intravitreally (ITV) injected in the presence or in the absence of recombinant human TGF-beta 1. The apoptotic markers Bax and …
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Drug nanosizing using microfluidic reactors. Development, characterisation and evaluation of corticosteroids nano-sized particles for optimised drug delivery.
… drug particles has shown potential in improving bioavailability. Drug nanosizing is achieved by ¿top-down¿ and by ¿bottom-up¿ approaches. Owing to limitations associated with the top-down techniques, such as high energy input, electrostatic effects, broad particle size distributions and …