Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"obligate intracellular bacteria"”.
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Identification and characterization of rickettsial proteins at the host-pathogen interface
Bacterial pathogens subvert host cell processes during infection by secreting protein effectors that manipulate host machinery. Cataloging such effectors has enabled a deeper exploration of the molecular basis of disease for numerous pathogens. Members of the Rickettsia genus are obligate …
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The rickettsial effector Sca4 has a conserved interaction with host clathrin and a tick cell specific role in infection
Intracellular bacterial pathogens secrete effectors to manipulate the host cell environment, create a hospitable niche, and promote infection. While many effectors interact with specific host machinery to perform a single distinct function, some effectors are capable of interaction with multiple …
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The tick response to Rickettsial dissemination during typical and atypical Rickettsial infection
… spotted fever group (SFG) Rickettsia which are obligate intracellular bacteria belonging to the genus Rickettsia. In nature, ticks maintain the infection of SFG Rickettsia via vertical and horizontal transmission. However, the prevalence of rickettsial transmission is limited to certain species …
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Ehrlichiosis: Understanding immune mechanisms that lead to the development of fatal disease
… and liver injury in the absence of overwhelming bacterial burdens, has led to the hypothesis that severe disease is immune-mediated. Our previous studies showed that intraperitoneal infection of wild-type mice with virulent Ehrlichia (IOE) results in CD8+ T cell-mediated fatal toxic shock-like …