Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"obesity and insulin resistance"”.
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Oligomeric cocoa procyanidins possess enhanced bioactivity compared to monomeric and polymeric cocoa procyanidins for preventing the development of obesity, insulin resistance, and impaired glucose tolerance during high-fat feeding
… However, research on the potential anti-obesity and anti-diabetic health benefits of cocoa flavanols is lacking in the literature. Furthermore, the effect that the size of these flavanols has on the extent of its beneficial properties is also unclear. The objective of this study was to …
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The role of beta3-adrenergic receptors in control of brown and white adipose tissues and of energy balance: Reversal of obesity by CL 316,243, a new beta3-adrenergic agonist.
Obesity is a prevalent health hazard that is associated with other metabolic disorders, in particular with insulin resistance and non-insulin-dependent diabetes mellitus. Treatment of obesity requires an increase in energy expenditure or a decrease in energy intake or both of these. One target for …
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Differentielle hepatische Genexpression in einem Mausmodell mit polygener Adipositas, Insulinresistenz und Hyperglykämie
New Zealand Obese (NZO) mice exhibit a polygenic syndrome of morbid obesity and insulin resistance, that resembles the human metabolic syndrome. In order to define its biochemical basis, the differential expression of genes involved in hepatic glucose and lipid metabolism was studied. An outcross …
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dLipin-A Link between Lipid Metabolism, Glucose Homeostasis and Growth in Drosophila melanogaster
… of neutral fats (triacylglycerols, TAG) and as transcriptional co-regulators that affect the expression of genes involved in lipid and fatty acid metabolism. Thus, they play central roles in metabolic control. Disruption of Lipin function has been implicated in lipodystrophy, obesity and …
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Equine obesity and its role in insulin resistance, inflammation and risk for laminitis
… were conducted to determine the effects of obesity on insulin resistance, inflammatory state and risk for laminitis, and the effectiveness of exercise training to reduce obesity and insulin resistance in equids. Practical methods of assessing adiposity were developed and verified, including …
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Lipid signalling dynamics of palmitate-induced endoplasmic reticulum stress in skeletal muscle
… potential mechanism driving the pathogenesis of obesity and T2DM. Palmitate, the predominant saturated fatty acid elevated in the blood plasma of obese individuals, induces ER stress and insulin resistance in skeletal muscle. However, the interaction between ER stress, lipid metabolism and T2DM …
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Influence of Exercise Modality on Body Composition, Insulin Resistance and Functional Fitness in Aging: A Randomized Controlled Trial
Excessive abdominal obesity, coupled with a decline in muscle mass and physical function that is exacerbated by sedentary living, contributes substantively to the disease and disability common to our aging population. The Senior Study, a randomized controlled trial designed to investigate the …
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Identifizierung und Charakterisierung von Suszeptibilitätsloci für Typ-2-Diabetes mellitus in einem Mausmodell für das Metabolische Syndrom
New Zealand Obese (NZO) mice exhibit a polygenic syndrome of morbid obesity, insulin resistance, and arterial hypertension that resembles the human metabolic syndrome. In addition, adult NZO-males are severely hyperglycemic and hypoinsulinemic. In order to localize the genes responsible for this …
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Depot differences in adipose tissue metabolism and function in obese black South African women and changes in response to an exercise training intervention
… (SA) women are disproportionally affected by obesity and insulin resistance, which have been associated with depot-specific alterations in adipose tissue function. This thesis aimed to evaluate the differences in fatty acid (FA) composition and gene expression between abdominal (aSAT) and …
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Role of PERM1 in the Development of Insulin Resistance and Diabetic Cardiomyopathy During High-Fat Diet Feeding
… methods to address this concern. PPARGC1 and ESRR Induced Regulator in Muscle 1 (PERM1) is a striated muscle-specific regulator of mitochondrial bioenergetics, predominantly expressed in skeletal and cardiac muscle. Our group has previously demonstrated that PERM1 is downregulated in both …
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The role of Integrin-Linked Kinase in regulating glucose and lipid homeostasis in adipose tissue
With decreased physical activity and increased energy intake, obesity and T2DM are steadily becoming a global health threat. Both these diseases can be associated to physiological disorders such as impaired glucose tolerance and insulin sensitivity. Although there is a wide range of treatments for …
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Investigation of plant derived compounds mediating cell signalling effectson FOXO1a and AMPK
… there has been a considerable increase in human obesity levels with an associated increase in the incidence of type 2 diabetes mellitus (T2DM), a disorder of glucose metabolism characterised by insulin resistance. It is unclear why obesity and insulin resistance should frequently exist comorbidly …
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Carnosic acid against insulin resistance and obesity. Investigating its effects on adipocytes.
… role in regulating metabolic homeostasis, and its dysfunction in obesity leads to insulin resistance and type 2 diabetes (T2D). White adipose tissue (WAT) primarily stores energy as lipids while brown adipose tissue (BAT) regulates thermogenesis by dissipating energy in a form of heat. The …
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Even a little is too much: A longitudinal study of weight gain in the cat
Obesity and insulin resistance has increased in the last three decades among humans and cats and has been associated with an increase in the inflammatory response and oxidative stress in people. The purpose of this study was to determine if an increase in fat mass was associated with an increased …
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Modelling altered Glucocorticoid Sensitivity: From HPA axis to metabolic abnormalities in mice and humans
… action are glucocorticoid receptor (GR) density and intracellular levels of ligand, the latter determined both by activity of the hypothalamic-pituitary-adrenal (HPA) axis and cellular activity of 11beta- hydroxysteroid dehydrogenase (11beta-HSD) enzymes that interconvert active 11- hydroxy …
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Shared Metabolic Pathways in Fuel-Stimulated Insulin Secretion
<p>Insulin secretion is a fundamental process of pancreatic beta-cells required for the maintenance of glucose homeostasis. Fuel-stimulated insulin secretion occurs in proportion to the rate of metabolism of fuel substrates, yet the signals generated by metabolism of these secretagogues are …
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Systems biology of diet-induced hepatic insulin resistance
Human obesity is a world-wide health crisis that promotes insulin resistance and type 2 diabetes. Obesity increases intracellular free fatty acid concentrations in peripheral tissues, particularly the liver, which disrupts molecular mechanisms that maintain normal glycemia in response to fasting …
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Integrated Microvascular Flow Regulation and the Impact of Metabolic Disease
… it is imperative that we begin to understand the fundamental relationships of arteriolar behaviour under normal healthy conditions. The reactivity of ex vivo proximal and in situ distal resistance arterioles from rat skeletal muscle was systematically determined when challenged by one-, …
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Cardiometabolic aspects of polycystic ovary syndrome
… It is characterised by chronic anovulation and hyperandrogenism with the clinical manifestation of oligomenorrhoea, hirsutism and acne. A ten to twenty fold increased risk for type 2 diabetes in PCOS patients compared to weight matched female control subjects makes the syndrome of high …
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The role of metabolic rate and substrate utilization in the maintenance of body weight, body composition and insulin sensitivity
Obesity treatment requires approaches that target the reduction of body weight and fat mass. The improvement of cardiorespiratory fitness (CRF), metabolic flexibility and insulin sensitivity also contribute towards reducing obesity-associated risk factors. While energy restriction alone results in …