Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 65 for “"obesity and diabetes"”.
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Prevention of Childhood Obesity and Diabetes
… concerns that have been on the rise is childhood obesity and diabetes. The National Health and Nutrition Examination Survey indicate that approximately one-third of children in the United States are overweight or obese with 17% meeting criteria for obesity (Pulgaron and Delamater, 2014). This …
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Genetics of Obesity and Diabetes in the IRAS Family Study
The prevalence of diabetes and obesity in the United States and abroad makes these common diseases a leading health concern. Research involving the discovery of genes contributing to these diseases is great public health importance. Identification of a gene and/or genes that contribute to the …
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Renal Cannabinoid Receptor Expression and Function: Their Role in Obesity and Diabetes
Obesity and diabetes are clearly established independent risk factors for renal disease. Therapeutic targets have been investigated for their role in treating obesity and diabetic associated renal damage. The endocannabinoid system is an important endogenous lipid signalling system known to mediate …
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Obesity and Diabetes: Evaluating the Impact of Promotores as a Prevention and Intervention Strategy in the Latino Community
<p>This paper aims to examine obesity and diabetes among the Latino population as a health problem. As the largest minority racial group in the U.S, Latino rates of obesity and diabetes are greatly higher than whites. The prevalence of obesity in Latinos is 45% compared to that of whites at 34.5% …
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Aib(2)oxyntomodulin Peptide Molecular Self-Assembly: Smart Nanostructures Toward Long Acting Formulation for Obesity and Diabetes Type 2
Type 2 diabetes mellitus (T2DM) and obesity are the most prevalent metabolic complications in the world. Previous studies have revealed that dual agonist gut hormone, oxyntomodulin (Oxm), has a promising beneficial role to treat obesity and T2DM through suppressing the food intake, raising the …
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A simple and effective model to study insulin resistance in obesity and diabetes and the processes and mechanisms of in vitro aging using lymphocyte culture
Cell culture provides a simple and effective system to study metabolic and cellular processes required for cellular growth in vitro. In this study, we demonstrate that lymphocyte culture can be used as a model system to study the mechanism of insulin resistance (obesity/diabetes) as well as the …
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Childhood Obesity Fieldwork Summary Report: The Food Education Project
<p>Childhood Obesity and diabetes is on the rise and the health risk for developing various diseases is a major public health issue. This paper examines the public health issue on childhood obesity and diabetes. This paper explains the importance and magnitude of this problem by providing …
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Obesity, Diabetes, and Disability in Older Mexican Americans, 1993-2011
Increases in obesity have been observed in both men and women, for all age groups and major ethnic groups, and at all educational levels. However, in Mexican Americans, the increased level of obesity only partially accounts for their higher prevalence of diabetes compared with non-Hispanic Whites. …
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Diabetes and Obesity Induce Transcriptomic and Metabolomic Changes Enhancing Pancreatic Cancer Aggressiveness
… that lacks effective diagnostic markers and therapies. It is expected that in 2014 the incidence and the mortality of pancreatic cancer in the United States will be 46,420 and 39,590 respectively. Diabetes and obesity are modifiable risk factors associated with accelerated pancreatic …
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The Impact of Health Education Among Communities w/ The Food Education Project: Exploring Healthy Eating to Modify Health Behaviors Among Youth, A Primary Intervention
<p>Obesity and diabetes among adults and children remains a public health concern. Rates of obesity among both demographics are slowly increasing. A plethora of research is available that unveils demographics of those who are at risk of obesity and diabetes. Barriers to healthy eating have also …
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The effect of circadian regulation and sleep disruption on metabolic homeostasis
Sleep and circadian disruption are ubiquitous in modern society. While the National Sleep Foundation recommends adults sleep 7-9 hours per night, the average sleep duration of American adults has decreased from ~8.8 hours to ~6.8 hours over the last century, with 1 in 3 people report sleeping fewer …
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From Flies to Mice: Drosophila as a Model System to Study Fat Biology
… species ranging from invertebrates to mammals and are essential for many aspects of the animal life cycle. Fat biology has taken on a new and urgent importance as it is intimately linked to one of the most prevelant and costly health problems of our time - obesity. Model organisms are a …
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As the Crow Flies: An Underrepresentation of Food Deserts in the Rural Appalachian Mountains
<p>Diet and dietary related health outcomes such as obesity and diabetes are major public health concerns. While personal choice and dietary behaviors are major influences on how an individual eats, the environment influences these choices and behaviors. The nutrition environment is one key …
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Interventions against obesity through increased lipolysis in adipose tissue
Obesity is a disease of excess adiposity affecting> 17% of men and >20% of women in Britain. Clinically, it is defined by a Body Mass Index (BMI, kg/m2) of 2:30. Obesity is a confounding factor that promotes insulin resistance, hyperinsulinaemia and type 2 diabetes. Type 2 diabetes accounts for …
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Hit Identification for PKCζ Inhibitors: Structure-Based Optimization, Virtual Screening, and Biological Evaluation
… some diseases, including inflammatory diseases, obesity and diabetes. Hit identification of PKCζ inhibitors was conducted by structure-based modification, virtual screening and biological evaluation. Among all the compounds selected and synthesized, compound JW-1-60A showed moderate activity …
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Investigating the Relationship between Markers of Ageing and Cardiometabolic Disease
… is accompanied by characteristic metabolic and endocrine changes, including altered hormone profiles, insulin resistance and deterioration of skeletal muscle. Obesity and diabetes may themselves drive an accelerated ageing phenotype. Untangling the causal web between ageing, obesity and …
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Measuring insulin sensitivity and the effect of alternative dietary interventions and exercise on metabolic control
… syndrome is highly prevalent in western society, and the numbers affected by obesity and diabetes continue to rise. This thesis reviews the mechanisms at play and the gaps in the literature that, if filled, may increase knowledge of treatment regimes for affected individuals. Experimentally, it …
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A STATISTICAL EXPLANATION OF THE EFFECT OF SOCIO-POLITICAL IDEOLOGY ON BLACK AMERICAN HEALTH
… incidence rates in conditions like hypertension, obesity, and diabetes in given populations do suggest that cultural factors influence morbidity. But rarely does research examine how political culture affects health. I investigate this relationship using four waves of the National Survey of Black …
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Statistical Approaches to Estimate Bidirectional and Time-Varying Causal Effects Using Mendelian Randomization
<p>Mendelian Randomization (MR) is an epidemiological framework using genetic variants as instrumental variables (IVs) to examine the causal effect of an exposure on an outcome. It is widely used to detect causal factors of diseases and provide insight into the biological pathway of diseases. …
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Lipotoxicity in smooth muscle
Atherosclerosis and bladder dysfunction can both result from the high lipid levels that occur with obesity and diabetes and can cause cell dysfunction and death, termed lipotoxicity, in various cell types. However, lipotoxicity has not been shown in smooth muscle. The goal of this dissertation was …
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