Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"ob/ob mice"”.
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Transport and Metabolism in the Gastrointestinal Tract of Diabetic Animals:a study involving lean and (ob/ob) mice
… transport of amino acids, in response to the (ob/ob) syndrome. The main adaptive response of the small intestine to the (ob/ob) syndrome was an increase in size due to proportionate increases in muscle and mucosa. The response was clearly an effect of hyperphagia, but, unlike other hyperphagic …
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The Identification of a Leptin Dependent Neural Pathway Regulating Adipose Tissue Innervation
… gene or its cognate receptor result in severe obesity in both human and mice. My thesis work revealed a leptin-dependent, plastic pathway spanning the central to peripheral nervous system that is responsible for regulating energy homeostasis in mice. Leptin deficient (ob/ob) mice accumulate …
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Interventions against obesity through increased lipolysis in adipose tissue
Obesity is a disease of excess adiposity affecting> 17% of men and >20% of women in Britain. Clinically, it is defined by a Body Mass Index (BMI, kg/m2) of 2:30. Obesity is a confounding factor that promotes insulin resistance, hyperinsulinaemia and type 2 diabetes. Type 2 diabetes accounts for …
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Structural and contractile alterations in skeletal muscles from the genetically obese (ob/ob) mouse: impairment or adaptation?
Obesity studies using humans are confounded by variables that are difficult to control and are restricted by ethical considerations. Given that they display many of the common attributes of obese humans, animal models of obesity have become invaluable tools for studying the etiology and related …
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Restriction of Food Intake by Dorsomedial Hypothalamus
<p>Leptin deficient ob/ob mice eat voraciously and their food intake is markedly reduced by leptin treatment. Leptin acts in part by regulating the activity of AGRP neurons and POMC neurons in the arcuate nucleus and neurons in other brain regions. In these dissertation, I will describe how we …
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Influence of genetic obesity on essential trace metal status and metabolism
Essential trace metal status in obese (ob/ob) mice and their lean(+/+ and +/?) littermates was assessed by measuring the concentrations and total levels of Zn, Fe, Cu and Mn in several tissues. Data indicated that the concentrations of these metals were significantly lower in several tissues from …
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Leptin and the Control of Body Weight and Metabolism: Role for Stearoyl CoA Desaturase-1 and Other Leptin-Regulated Genes in the Liver
… neuroendocrine response to altered nutrition. Mice lacking leptin (ob/ob) or its receptor (db/db) are massively obese and hyperphagic. They also have increased triglyceride deposits in multiple peripheral organs, including the liver, massively enlarged and steatotic. Leptin elicits a metabolic …
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Galanin-like peptide: a molecular link between energy homeostasis and reproduction
… (ICV) GALP injections to wild-type and mutant mice. I observed that ICV GALP elicits rapid but transient reductions in feeding and body weight in wild-type mice. However, acute ICV GALP treatment also reduces locomotor activity and elicits the formation of a conditioned taste aversion, which …
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The Association between Obesity, Cognition, and Visual Function
Purpose: Obesity is an adverse health condition characterized by excessive weight gain. Aside from the pathological conditions most commonly associated with obesity, recent epidemiological studies have suggested that obesity may be associated with impaired learning and memory. Previous research has …
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A Study of Glucose Stimulus Insulin Secretion Coupling using Lean and Obese Mouse Islets of Langerhans
… from lean homozygous (+/+) and genetically obese hyperglycaemic (ob/ob) mice. Streptozotocin inhibition of the insulin response to glucose but not glucagon suggests glucose sensitive sites and adenylate cyclase systems to be separate physiological entities at the level of the B-cell …
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The effects of novel and synthetic estrogens on liver health and microbiome crosstalk
… but do not increase the risk of cancers. The objective of these studies is to evaluate the effects of novel and synthetic estrogens on metabolism by analyzing transcriptomic, metabolomics, and microbiome data in mouse and cell line models. Additionally, a potential mechanism of interaction …
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Functional responses of cardiac and skeletal muscle mitochondria to short-term obesity: are all obesities the same?
Obesity is associated with metabolic alterations, specifically in the mitochondria, that may play a role in the development of insulin resistance and type 2 diabetes. In nature, there are circumstances where obesity is normal, even favored as seen in mammals that hibernate (hibernators). …
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The Role of Akt2 in Hepatic Lipid Metabolism
Insulin drives the global anabolic response to nutrient ingestion, regulating both carbohydrate and lipid metabolism. When insulin resistance occurs in Type 2 Diabetes Mellitus, dysregulation of both of these processes ensues, resulting in hyperglycemia and lipid abnormalities. One of the most …
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Investigation of potential intervention targets to improve insulin action: a therapeutic approach
… regulation of body weight; sibutramine, an antiobesity agent; plant-derived compounds (pinitol and chamaemeloside) and agents known to affect insulin sensitivity, e.g. metformin, tolbutamide, thiazolidinediones, vanadyl sulphate and thioctic acid. Models used for investigation included the L6 …
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Rgs16 is a Pancreatic Reporter of Chronic Hyperglycemia in Diabetes
… Rgs16::GFP expression. We investigated diabetic mice to determine if Rgs16::GFP would reactivate during beta cell expansion in adulthood. The type 1 diabetic models of beta cell death were streptozotocin (STZ) treatment and PANIC-ATTAC mice. Type 2 diabetic models consisted of ob/ob mice and diet …
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Treating type 2 diabetes through insulin resistance
… and the diverse effects of insulin resistance. Obesity, in particular central obesity, is a strong pre-disposing factor for type 2 diabetes. Skeletal muscle is the main site of insulin-stimulated glucose disposal and appears to be the first organ that becomes insulin resistant in the diabetic …
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Cellular and Molecular Mechanisms Underlying Leptin's Metabolic Effects
<p>Obesity is rapidly increasing in prevalence, and has become one of the leading contributors to poor health in the world. Increased body weight by necessity must be a result of increased nutrient intake relative to total energy expenditure. While many have focused on the importance of caloric …
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The Interaction of Obesity and Age and their effect on Adipose Tissue Metabolism in the Mouse
… how bulk lipid metabolism is influenced in obesity and in particular how the composition of triglycerides found in the cytosol change with increased adipocyte expansion. However, in part reflecting the analytical challenge the composition of cell membranes, and in particular …
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Adipose tissue transplantation improves metabolic, behavioural and histological parameters in leptin-deficient mice
… to normalise the phenotype of leptin-deficient ob/ob mice through white adipose tissue (WAT) transplantation has been applied. Perigonadal WAT was harvested from congenic NZegTg+/ Lep+/+ mice, which express nuclear enhanced green fluorescent protein (EGFP) at very high levels in all cells. …
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