Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"ob/ob"”.
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Structural and contractile alterations in skeletal muscles from the genetically obese (ob/ob) mouse: impairment or adaptation?
Obesity studies using humans are confounded by variables that are difficult to control and are restricted by ethical considerations. Given that they display many of the common attributes of obese humans, animal models of obesity have become invaluable tools for studying the etiology and related …
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Transport and Metabolism in the Gastrointestinal Tract of Diabetic Animals:a study involving lean and (ob/ob) mice
… transport of amino acids, in response to the (ob/ob) syndrome. The main adaptive response of the small intestine to the (ob/ob) syndrome was an increase in size due to proportionate increases in muscle and mucosa. The response was clearly an effect of hyperphagia, but, unlike other hyperphagic …
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Der Einfluss des Eisenstoffwechsels und die Rolle der peripheren nervalen Inflammation in der Entwicklung der peripheren Neuropathie bei adipösen nichtdiabetischen leptindefizienten ob/ob-Mäusen
… konnten periphere Nervenschäden aufzeigen, wobei es vor allem zu einer Gewebsdegeneration distaler Axone kam. Vermutlich stellt die umgebende Entzündungsreaktion, die wir anhand der hohen Anzahl von Monozyten und autokriner Zytokine detektierten, einen ausschlaggebenden Faktor im …
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Einfluss von Glucolipotoxizität auf die Funktion der β-Zellen diabetessuszeptibler und –resistenter Mausstämme
… in einem diabetesresistenten (B6.V-Lepob/ob, ob/ob) sowie diabetessuszeptiblen (New Zealand Obese, NZO) Mausmodell zu untersuchen. Es sollten molekulare Mechanismen identifiziert werden, die zum Untergang der β-Zellen in der NZO-Maus führen bzw. zum Schutz der β-Zellen der ob/ob-Maus …
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Leptin and the Control of Body Weight and Metabolism: Role for Stearoyl CoA Desaturase-1 and Other Leptin-Regulated Genes in the Liver
… to altered nutrition. Mice lacking leptin (ob/ob) or its receptor (db/db) are massively obese and hyperphagic. They also have increased triglyceride deposits in multiple peripheral organs, including the liver, massively enlarged and steatotic. Leptin elicits a metabolic response that cannot …
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The Identification of a Leptin Dependent Neural Pathway Regulating Adipose Tissue Innervation
… gene or its cognate receptor result in severe obesity in both human and mice. My thesis work revealed a leptin-dependent, plastic pathway spanning the central to peripheral nervous system that is responsible for regulating energy homeostasis in mice. Leptin deficient (ob/ob) mice accumulate …
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Growth Hormone and Melanin-Concentrating Hormone receptor in the regulation of energy balance and metabolism
… have higher food intake and body weight and are obese compared with wild-type (WT) mice. Moreover, GFAP-bGH mice had hyperinsulinemia, pancreas islet hyperplasia, and dyslipidemia, but no changes in energy expenditure were observed. Thus, GH is an orexigenic signal in the CNS that leads to …
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Interventions against obesity through increased lipolysis in adipose tissue
Obesity is a disease of excess adiposity affecting> 17% of men and >20% of women in Britain. Clinically, it is defined by a Body Mass Index (BMI, kg/m2) of 2:30. Obesity is a confounding factor that promotes insulin resistance, hyperinsulinaemia and type 2 diabetes. Type 2 diabetes accounts for …
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Restriction of Food Intake by Dorsomedial Hypothalamus
<p>Leptin deficient ob/ob mice eat voraciously and their food intake is markedly reduced by leptin treatment. Leptin acts in part by regulating the activity of AGRP neurons and POMC neurons in the arcuate nucleus and neurons in other brain regions. In these dissertation, I will describe how we …
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The Association between Obesity, Cognition, and Visual Function
Purpose: Obesity is an adverse health condition characterized by excessive weight gain. Aside from the pathological conditions most commonly associated with obesity, recent epidemiological studies have suggested that obesity may be associated with impaired learning and memory. Previous research has …
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Insulin resistance and cardiovascular function - Observational, translational and interventional studies
… understanding, we hypothesized that obese insulin resistant leptin-deficient (ob/ob) mice could be a potential model for microvascular dysfunction and associated mechanisms. Finally, we hypothesized that short-term personalized lifestyle intervention may improve coronary …
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Influence of genetic obesity on essential trace metal status and metabolism
Essential trace metal status in obese (ob/ob) mice and their lean(+/+ and +/?) littermates was assessed by measuring the concentrations and total levels of Zn, Fe, Cu and Mn in several tissues. Data indicated that the concentrations of these metals were significantly lower in several tissues from …
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Obesity-Induced Alterations in Sperm Quality, Testicular Morphology, and Extracellular Vesicle Localisation in Male Mice
… concurrent evidence of declining semen quality. Obesity is a major contributor to infertility, with obese men presenting with decreased testosterone levels, impaired spermatogenesis and reduced sperm function. Extracellular vesicles (EVs), which facilitate cell-to-cell communication, have been …
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Defining the metabolic effect of peroxisome proliferator-activated receptor δ activation
… activation in white adipose tissue from the ob/ob mouse model of insulin resistance, and in the phenotyped 3T3-L1 adipocyte model, were investigated. PPAR delta activation was distinguished by oxidative catabolism of fatty acids and citric acid cycle intermediates. Conversely, PPAR gamma …
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The effect of oral-hypoglycaemic drugs and obesity on insulin receptor binding
… effects of insulin action. The Aston obese hyperglycaemic (ob/ob) mouse was used as an animal model of obesity and type 2, NID diabetes mellitus. Hepatocyte insulin receptor number and soleus muscle insulin binding were reduced in these mice compared to lean litter mates. The rate of …
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Neural Mechanisms of Homeostatic Need and Reward
… need-sensing neurons causes diseases such as obesity and sleep disorders,both of which are key risk factors for a shorter lifespan across animal species including human. This thus raises two key questions in neurobiology of need and homeostasis: 1. How do need-sensing neurons maintain …
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Galanin-like peptide: a molecular link between energy homeostasis and reproduction
… GALP injections to wild-type and mutant mice. I observed that ICV GALP elicits rapid but transient reductions in feeding and body weight in wild-type mice. However, acute ICV GALP treatment also reduces locomotor activity and elicits the formation of a conditioned taste aversion, which raises the …
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Life Without GPR7, the Neuropeptide W1 Receptor: Regulation of Energy Homeostasis by GPR7 and its Endogenous Neuropeptide Ligands
… hypothalamus (VMH) resulting in hyperphagia and obesity. To identify genes involved in the hypothalamic regulation of energy homeostasis, we employed a screen to search for genes that were dysregulated in GTG induced obese mice. In this screen, GPR7, the endogenous G protein-coupled receptor …
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Treating type 2 diabetes through insulin resistance
… and the diverse effects of insulin resistance. Obesity, in particular central obesity, is a strong pre-disposing factor for type 2 diabetes. Skeletal muscle is the main site of insulin-stimulated glucose disposal and appears to be the first organ that becomes insulin resistant in the diabetic …
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