Global ETD Search
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Showing 1 to 2 of 2 for “"nukacin ISK-1"”.
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Investigation of the Lacticin 481 Synthetase and Its Substrate LctA in the Production of the Antibiotic Lacticin 481
… class II lacticin 481 family members including nukacin ISK-1, mutacin II and ruminococcin A. Finally, ICP analysis revealed LctM is a metalloprotein containing one equivalent of zinc. Mutation of the zinc ligands C781 and C836 to alanine in LctM did not affect dehydration activity but did impair …
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New chemical and biosynthetic methodologies for the study of lanthipeptides
Recent genome sequencing efforts have revealed that a common biosynthetic route to peptide natural products involves ribosomally synthesized and posttranslationally modified peptides (RiPPs). One of the largest classes of RiPPs is the lanthionine-containing peptides (lanthipeptides), which are …