Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 94 for “"nude mice"”.
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The Interaction of Equol and Genistein on Estrogen Dependent Tumors and Bones in Ovariectomized Athymic Nude Mice
… and bone development in ovariectomized athymic nude mice. In the first study, the experiments were conducted to evaluate the effect of equol alone on the T47D human breast cancer cells and bone metabolism. At the physiological concentration levels, 100 nM equol stimulated the T47D cell …
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MICRO-CT EVALUATION OF MSC/HUVEC/HSC-MEDIATED ANGIOGENESIS IN LARGE PCL-ßTCP CONSTRUCTS IMPLANTED IN NUDE MICE
… hybrid scaffold in an immuno-compromised nude mouse. The PCL-ßTCP scaffold (30% PCL: 70% ßTCP; 70% porosity) with interconnected open pores was fabricated in 6x6x6mm cubes. They were seeded with human mesenchymal stem cells (MSCs) plus HUVECs or HSCs. Groups (N=12) consisted of scaffold …
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Immunohistochemical analysis of a panel of human and murine markers on xenografted human vaginal mucosa: a comparative study
Athymic nude mouse models have been extensively used to study biological behaviour of normal and diseased human tissues. In such models, immune-deficient mice act as hosts for cysts constructed from human material. A unique biocyst model that entails transplantation of human vaginal cysts into …
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Reduction of tumorigenesis in androgen receptor overexpressed Huh7 cells through TGF-β induced cellular senescence phenotypes
… and in vitro tumorigenesis were evaluated in nude mice as well as in cell culture systems. RESULTS: AR overexpressing Huh7 cells, Huh7-AR, and its control, Huh7-V cells, were established. AR expression was measured by RT-PCR and immunoblot analyses. Huh7-AR cells, which were responsive to 5 …
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An experimental study of human melanoma cells cutured in vitro
… with in vivo behaviour as measured in the nude mouse. Melanoma cell lines were established from biopsy material obtained from 7 patients at Groote Schuur Hospital. Two of these lines synthesized tyrosinase and melanin at a rate that was directly related to cell density. The five remaining …
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Mechanisms of IFN-gamma-mediated Resistance against Development of Toxoplasmic Encephalitis
… of reactivation of chronic infection in BALB/c mice. This strain of mouse is genetically resistant to T. gondii infection and establishes a latent chronic infection as do immunocompetent humans, and therefore provides an excellet model for this purpose. Our laboratory previously demonstrated …
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Targeting Prostaglandin E2 Receptor EP2 for Treatment of High-Risk Neuroblastoma
… the development of NB xenografts in athymic nude mice. Additionally, EP2 conditional knockdown prevented established tumors from progressing in vivo. Pharmacological inhibition of EP2 by our recently developed antagonist TG6-129 substantially suppressed the NB tumor growth in both nude mice …
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Food processing modulation on breast cancer
… from stimulating MCF-7 tumor growth in athymic nude mice, indicating that other bioactive compounds in soy can negate the estrogenic properties of isoflavones. The underlying signal transduction pathways to explain the protective effects of soy flour consumption were studied. Ovariectomized …
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Evaluation of IP-10 and TNFalpha-transducing parvoviral vectors as antitumoral agents in animal glioblastoma models
… used for inducing subcutaneous tumors in C57/Bl6 mice and human U87 glioblastoma cells produced subcutaneous tumors in cd1 swiss nude mice. The antitumoral effects mediated in vivo by recombinant and wild type parvoviruses (MVMp and H1) were investigated in these animal models. High efficacy of …
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The Effects of Low Intensity Ultrasound on Chondrogenic Differentiation of Rabbit Mesenchymal Stem Cells In Vivo
… implanted into the subcutaneous in the back of nude mice. While ultrasound group received the direct stimulation with the LIUS in vivo for 20 min every day up to 4 weeks, control group had no LIUS stimulation. In the Study II, PGA-MSCs constructs were divided into four subgroups of the untreated …
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Investigating The Role of Cd109 In Pancreatic Ductal Adenocarcinoma
… it promotes tumor formation and progression in nude mice, therefore decreasing their survival. We revealed an association between CD109 expression and YAP/TAZ signaling through RPPA and RNA Sequencing data. This data establishes CD109 as a cell surface protein exclusively expressed in PDAC …
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Auger-emitter radiochemotherapy in squamous cell cancers : in vitro and in vivo experiments with In-111-BLMC
… HNSCC using in vitro HNSCC cell lines, in vivo nude mice, and in vivo HNSCC patients. In in vitro experiments with HNSCC cell lines, the sensitivity to external beam radiation, BLM, In-111-BLMC, and In-111-Cl3 was studied using the 96-well plate clonogenic assay. The influence of BLM and …
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Novel mechanism of gastric proton pump inhibitor (PPI) : Suppression of Helicobacter-pylori induced angiogenesis and selective induction of apoptosis in gastric cancer cells.
… was evaluated in vivo by a xenograft model of nude mice. And, to address the relationship between H.pylori infection and angiogenesis, comparative analysis of density of CD34+ blood vessel was performed in tissues obtained from 20 H.pylori positive gastritis and 18 H.pylori negative gastritis …
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PHOSPHORYLATION OF NF-ΚB RELA/P65 ON SER536 SIGNALS CANCER CELLS TO DEATH AND ENHANCES CHEMOSENSITIVITY
… p65/S536D effectively suppressed tumor growth in nude mice and was marked with apoptotic cell death. Together our data suggest that it is the phosphorylation at Ser536 that confers NF-kappaB RelA/p65 a tumor-suppressive role. In addition to driving cell death, the phosphorylation of RelA/p65 on …
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Investigating a novel small molecule inhibitor of nuclear import as an anti-cancer approach
… INI-43 has an acceptable toxicity profile in nude mice and is metabolically stable, allowing its use in in vivo testing. Intraperitoneal administration of INI-43 significantly reduced the growth of subcutaneously xenografted cervical and oesophageal tumour cells in nude mice, supporting its …
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Regulation of HPV infection and cervical cancer development following a helminth infection
… the draining lymph node of the FGT. Coinfected mice demonstrated a popula7on of eosinophils expressing lower levels of Ly6C and higher levels of CD11b, a recruitment marker. When eosinophil recruitment was blocked, the helminth-dependent reduc7on in HPV infec7on is lost, sugges7ng these immune …
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THE ROLE OF TETRASPANIN-8 IN ASTROCYTE ELEVATED GENE-1 MEDIATED PROGRESSION OF HEPATOCELLULAR CARCINOMA
… orthotopic xenografts in the livers of athymic nude mice. TSPAN8 might be a useful diagnostic marker and potential therapeutic target for HCC. These findings indicate that upregulation of TSPAN8 might be an important event in mediating the oncogenic function of AEG-1.
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Gene Therapy for Osteosarcoma : "In Vitro" Characterization of Five Tumor Cell Lines and Development of Treatment Models "In Vivo"
… to develop a series of experiments in athymic nude mice to investigate the utility of gene therapy for the treatment of experimental osteosarcomas. Subcutaneous implants of mixtures of tumor cells and HS-tk vector producer cells (vpc) resulted in the development of tumors which were completely …
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