Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"nucleotide synthesis"”.
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Some in vivo effects of triiodothyronine on purine nucleotide synthesis
The in vivo effects of triiodothyronine on the synthesis of hepatic purine nucleotides was investigated in sulfaguanidine-fed hypothyroid rats. To prevent the rapid destruction of nucleotides caused by anoxia and ischemia an apparatus was designed to maintain ether anesthesia while providing normal …
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Towards a synthetic metabolism: exploitation of synthetic and natural nucleotide synthesis pathways for in vitro gene expression
Contains fulltext : 175865.pdf (Publisher’s version ) (Open Access)
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ELUCIDATION ON THE MECHANISM OF CAMKKα AS A PRO-GROWTH KINASE IN MOUSE SKELETAL MUSCLE
… 2) Post resistance exercise, muscle protein synthesis is highly active, which stimulates glucose uptake to provide ATP and carbons for anabolism. For individuals that are unable to exercise, it is critical to elucidate the mechanisms by which resistance exercise stimulates these processes, to …
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The development of novel metabolic therapies for the treatment of glioblastoma
… in the utilisation of glutamine for de novo nucleotide synthesis (PPAT, CAD) were upregulated in the large majority of tumour biopsies, while those involved in glutaminolysis (GLS1, GLS2) were near-universally downregulated. In summary, the data of this thesis reinforced HK2’s potential as a …
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PROGRAMMED ADDICTION OF PANCREATIC CANCER TO NUCLEOTIDE METABOLISM BY THE TUMOR MICROENVIRONMENT
… of tumor-stellate cells crosstalks in sustaining nucleotide synthesis – a substrate and energy-intensive process. Using patient-derived co-cultured models that closely recapitulated PDAC histology, KRAS genotype and gemcitabine response, I uncover that stellate cells strategized nutrient sharing …
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Metabolic regulation of mammalian cell growth and proliferation
… acids. In addition, cells must coordinate biosynthesis and production of specific macromolecules with the events that enable cell cycle progression. A cell’s ability to fulfill these anabolic requirements is impacted by environmental factors that influence how the metabolic network is used. …
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LINKING CHROMATIN REMODELING TO MITOCHONDRIAL DYSFUNCTION: A ROLE FOR THE SMARCA5-MYC-TFAM AXIS IN HEPATOCELLULAR CARCINOMA
… impaired β-oxidation of fatty acids, diminished nucleotide synthesis, and defective amino acid catabolism, indicating a collapse in mitochondrial biosynthetic processes, leading to cancer cell death. Mechanistically, loss of SMARCA5 emerged as a major driver of MYC signaling impairment, resulting …
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Coordinated regulation of glycolysis and the folate one-carbon cycle
… supports proliferation by increasing serine synthesis from upstream glycolytic intermediates. This diverts one-carbon units into the folate pool to generate nucleotides via phosphoserine inhibition of SHMT1-mediated serine synthesis and one-carbon "wasting" in some cancer cells. We will also …
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Regulation of the mTORC1 growth pathway by amino acids
… many processes, such as protein, lipid, and nucleotide synthesis, as well as autophagy. Given that mTORC1 regulates a multitude of processes, it is not surprising that the pathway it anchors is deregulated in various common diseases, including cancer. The Rag GTPases interact with mTORC1 and …
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We are what we eat : identifying a regulatory crosstalk between central carbon metabolism and cell division in bacteria
… evidence for the role of DNA replication and nucleotide synthesis in the Z ring positioning defect of ∆𝘱𝘺𝘬 cells. Collectively, the work presented here demonstrates the importance of one specific metabolite - pyruvate, in maintaining the coordination between the cellular events of division, …
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The Identification and Targeting of Altered NAD+ Metabolism in Glioblastoma
… redox balance, and DNA-damage repair, and its biosynthesis and consumption are elevated in GBM. This dissertation investigates the upregulation of NAD+ metabolism in GBM and evaluates multiple strategies to target this vulnerability. We first performed transcriptomic analyses from The Cancer …
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Host/virus interactions in the marine cyanobacterium prochlorococcus
… in diverse cellular processes, including photosynthesis, carbon and phosphate metabolism, and nucleotide synthesis. They are thought to benefit phage during infection by redirecting host metabolism towards pathways that promote viral replication. While AMGs are widespread in two Prochlorococcus …
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The DNA damage response to ATR inhibition
… synthetase (PRPS) complex involved in nucleotide synthesis. These preliminary findings suggest the existence of a novel regulatory mechanism at the intersection of DNA damage, transcription, and nucleotide metabolism, which may function to promote genome stability.
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Vitamin B12-mediated physiology, mutualisms, and gene regulation studies in Chlamydomonas reinhardtii and Phaeodactylum tricornutum
… which is important for amino acid (methionine) synthesis via METE or METH, nucleotide synthesis, and broader methylation patterns, was next investigated in C. reinhardtii and P. tricornutum. Observed were higher differential expression of C1 cycle transcripts in both C. reinhardtii and P. …
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The Mitochondrial Fusion Protein, Optic Atrophy 1 (OPA1), Alters Cellular Metabolism to Support Cancer Cell Viability
… intermediates of amino acids, TCA cycle and nucleotide biosynthetic pathways. To investigate nutrient usage, we performed stable isotope tracer analyses using [13C5]- and [15N2]-glutamine, which revealed increased incorporation into amino acid derivatives, TCA cycle, and pyrimidine …