Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 21 for “"nucleotide substitution"”.
-
Analysis of the impact on phylogenetic inference of non-reversible nucleotide substitution models
… models that assume that the relative rates of substitution for any given pair of nucleotides are the same regardless of the direction of the substitutions. However, there is no reason to assume that the underlying biochemical mutational processes that cause substitutions are similarly …
-
The Discovery and Evolutionary Analysis of Divergent Homologs Involved in Cattle Immune and Reproductive Biology
… PRP8, PRP9, PRP11, SECTM1A and SECTM1B. Nucleotide substitution analysis provided evidence for positive selection in members of the PRP gene family, SECTM1A and SECTM1B. Gene expression profiles, motif predictions, and annotations of homologous sequences indicate immunological and …
-
The complete plastid genome sequence of Passiflora cincinnata: genome rearrangements, massive plastid gene losses and implications to genome-plastome incompatibility
… plastid. This genome also showed a high rate of nucleotide substitution in several genes, such as accD and clpP. Despite this high divergence, the translated amino acid sequences of these genes retain most of functional domains predicted indicating that they can still encode functional proteins. …
-
Autoregulation of Xenopus estrogen receptor gene expression is mediated by a novel estrogen response element in the protein coding region
… from the consensus ERE (cERE) by a single nucleotide substitution on one arm of the palindrome. Biological function was tested by inserting two copies of the Xenopus estrogen receptor ERE (xERE) into the chloramphenicol acetyltransferase (CAT) reporter plasmid, ATCO, and performing …
-
Phylogenetics of North American Psoraleeae (Leguminosae): Rates and Dates in a Recent, Rapid Radiation
… are used to investigate divergence dates, nucleotide substitution rates, diversification rates, and the impact of climate change, past and present, on diversification of NAm Psoraleeae. Results suggest the group has undergone a recent, rapid radiation. Rates of molecular evolution are fast, …
-
Investigations of the Accuracy of Partial Genome Sequencing and Restriction Fragment Analysis in Determination of Genetic Relationships: A Computer Simulation Study
… of genetic factors (genome length, overall nucleotide substitution rate, and extent of rate variation among sites) and model tree parameters (extent of rate variation among lineages, tree imbalance, and tree stemminess) on accuracy were also evaluated. Thirty-two model trees, each with …
-
Complex evolution of mitochondrial genomes: lessons from salamanders
… aspects of mitochondrial genome evolution (i.e. nucleotide substitution, accumulation of non-coding sequences) are differently affected by metabolic variation across tetrapod lineages. Chapter Two describes the correlation between gene rearrangement/genome expansion and increased rates of …
-
A Morphological and Phylogenetic Comparative approach to investigating Branching Architecture Evolution in Monocots A Dissertation
… approach are based largely on models of nucleotide substitution for discrete states. The third chapter seeks to achieve a more realistic understanding of branching architecture evolution by incorporating morphospaces into comparative analyses. This was done by “rescoring” inflorescence …
-
Molecular evolutionary analysis of the American pika (Ochotona princeps)
<p>American pika (<em>Ochotona princeps</em>) are small winter-active mammals inhabiting alpine environments. As the American pika occupies a niche characterized by hypoxia, these animals are an excellent system to use for detecting genetic changes associated with adaptation to these conditions. …
-
Micro-evolution of foot-and-mouth disease virus
… that arose over the course of this epidemic. 197 nucleotide substitutions were observed at 191 different sites across the genome, with a ratio of non-synonymous to synonymous change of 0.09. It was estimated that the date at which FMDV first infected livestock in the UK was the 7th February 2001 …
-
Algorithms for estimating rates of nucleotide change
… acquisition of genome-wide data for estimating nucleotide rates not only including mutation rates within species, but including substitution rates between species from multiple sequence alignments. To address the problem of estimating mutation rates within species, Vogl (2014) has developed a …
-
Algorithms for estimating rates of nucleotide change
… acquisition of genome-wide data for estimating nucleotide rates not only including mutation rates within species, but including substitution rates between species from multiple sequence alignments. To address the problem of estimating mutation rates within species, Vogl (2014) has developed a …
-
The impact of common and rare human genetic variants on erythrocyte invasion by Plasmodium falciparum malaria parasites
… to invade red blood cells (RBCs). A single nucleotide substitution in the promoter of the gene where erythroid-specific transcription factors bind disrupts the expression of the DARC receptor on the surface of RBCs, and individuals who are homozygous for the mutation are termed …
-
Maize R gene Rxo1 Confers Disease Resistance on Pepper and Nicotiana benthamiana
… that AvrRxo1 could directly interact with the nucleotide-binding domain of Rxo1 in vivo and in vitro. We further demonstrated that the nucleus localization of AvrRxo1 was required for its avirulence and virulence functions. In addition, the cytosol localization of Rxo1 was also necessary to …
-
DNA Binding Protein’s Structure, Mechanism, and Functional Relevance; From Filament Formation of SgrAI to Helicase Activity of B19V-NS1
… According to structural and kinetic studies, substitution of the second base pair of the primary site can change the energy between the inactive (T state) and active (R state) states in a way that favors the T state and, as a result, prevents the formation of filamentous structures. However, …
-
Transcriptional Regulation of Azole Antifungal Resistance in Candida albicans
… contained one UPC2 allele harboring a single nucleotide substitution, resulting in a G648D exchange. Introduction of the mutated UPC2 allele into the genome strain resulted in constitutive up-regulation of ERG11 and increased resistance to fluconazole. By comparing the gene expression profiles …
-
Understanding angiosperm genome interactions and evolution: insights from sacred lotus (Nelumbo nucifera) and the carrot family (Apiaceae)
… of its history of vegetative propagation, low nucleotide substitution rate, and lack of several paleo-duplications. Unlike N. nucifera, and the majority of other angiosperms, the plastomes of several members of the apioid superclade within the carrot family (Apiaceae or Umbelliferae) have …
-
Meccanismi evolutivi dei parapoxvirus: caratterizzazione genomica di pseudocowpoxvirus e messa a punto di sistemi per lo studio delle ricombinazioni
… response to infection. Given the low rate of nucleotide substitution, recombination can be seen as an essential evolutionary driving force although it is likely underestimated. Recombination in poxviruses is intimately linked to DNA replication with both viral and cellular proteins participate …
-
Analysis of DOCK2 and SENP2 mutations on the immune system and CD8 T cell survival
… The second mutation was a synonymous exonic nucleotide substitution in Senp2, encoding a specific protease for cleaving the ubiquitin-like SUMO protein from its conjugates with other proteins, whose critical role in T cells had not previously been shown. Mice homozygous for the ‘dockland’ …
-
Analysis of DOCK2 and SENP2 mutations on the immune system and CD8 T cell survival
… The second mutation was a synonymous exonic nucleotide substitution in Senp2, encoding a specific protease for cleaving the ubiquitin-like SUMO protein from its conjugates with other proteins, whose critical role in T cells had not previously been shown. Mice homozygous for the ‘dockland’ …
Page 1 of 2