Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"nucleotide signaling"”.
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Phosphodiesterase 1 (PDE1) at the Crossroads of Calcium and Cyclic Nucleotide Signaling in Diabetic Nephropathy
… DKD. While renoprotection is mediated by cyclic nucleotides (cAMP and cGMP), phosphodiesterases (PDEs) lead to cyclic nucleotide degradation. Our investigation focused on the role of calcium/calmodulin activated PDE1 in DKD. Three isoforms of PDE1 are differentially expressed in vascular smooth …
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Uncovering New Mechanisms of Type III CRISPR-Cas System Inhibition and Effector Function
… ATP into cyclic oligoadenylates. These act as signaling molecules that bind to CRISPR-associated Rossmann Fold (CARF) proteins and activate their effector domains. The effector part unleashes various activities that are toxic to the host cell, inhibiting cell growth and leading to growth …
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Development of a Microplate-Based Calcium Assay for Studying Desensitization of the P2Y2 Nucleotide Receptor
Extracellular nucleotides mediate cellular responses in a variety of tissues by binding to either the ionotropic P2X family or metabotropic P2Y family of nucleotide receptors. The P2Y2 receptor (P2Y2R) regulates several important processes, such as inflammation, neuroprotection, and NaCl balance on …