Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"nucleotide exchange factors"”.
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Regulation of rho guanine nucleotide exchange factors through lipid binding and phosphorylation
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-08-01
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Identification of a family of cAMP-binding guanine nucleotide exchange factors by Gregory M. Springett.
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1998.
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Identification and Characterization of Novel Mechanisms of Functional and Structural Synapse Remodeling: Focus on Vav Guanine Nucleotide Exchange Factors and MEF2 Transcription Factors
… study, I identify a novel role for Vav guanine nucleotide exchange factors (GEFs) in brain-derived neurotrophic factor (BDNF)-dependent synapse plasticity. BNDF and its receptor, TrkB, are well-established positive modulators of hippocampal long-term potentiation (LTP), and increasing evidence …
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Regulation of Net1A Subcellular Localization By The Small Gtpase Rac1
… by a family of enzymes known as guanine nucleotide exchange factors (Rho GEFs). The neuroepithelioma transforming gene 1 (Net1) is a Rho GEF specific for the RhoA subfamily that is overexpressed in primary breast tumors and breast cancer cell lines. Net1 isoform expression is also …
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Determining the differential roles of the dock family of GEFs in drosophila development
… Dock proteins function as unconventional guanine nucleotide exchange factors (GEFs). Upon binding to ELMO (Engulfment and cell motility) proteins, Dock-ELMO complexes activate the Rho family of small GTPases to mediate a diverse array of biological processes, including cell motility, apoptotic …
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Regulation of p190RhoGEF by Activated Rho and Rac GTPases: Amplification and Crosstalk
… of Rho proteins largely depends on Rho Guanine nucleotide Exchange Factors (RhoGEFs), which catalyze the exchange of GTP for GDP on Rho. For classical RhoGEFs, the exchange activity resides in a Dbl homology (DH) domain, which is linked to a pleckstrin homology (PH) domain that subserves various …
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Modulation of mitotic progression and cell cycle checkpoints by phosphorylation-dependent protein-protein interactions
… regulation of cytokinesis-specific guanine-nucleotide exchange factors for the small G-protein Rho is necessary for proper actomyosin ring contraction and cytokinesis. Additionally we demonstrate that Polo-like-kinase-1 directly regulates the activity of the Rho-effector-kinase ROCK2, and …
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Upregulation of PIP3-dependent RAC Exchanger 1 (P-Rex1) Promotes Prostate Cancer Metastasis
Activation of Rac by guanine-nucleotide exchange factors (GEFs) at the leading edge of the cell plays an important role in directional cell migration, a critical step of tumor metastasis cascades. We investigated the role of P-Rex1, a novel specific GEF for Rac, in human prostate cancer metastasis. …
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Rab5 Activation by the Vps9 Domain
… the release of GDP and reloading of GTP. These nucleotide exchange factors contain additional domains which link them to specific cellular locations or signaling cascades. The multiplicity of these Rab5 proteins and exchange factors raises the question of how these proteins specifically interact …
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Activated RhoA Positively Regulates Exchange Activity of PDZ-RhoGEF
… state. This cycle is mediated by guanine nucleotide exchange factors (GEFs) that increase the rate of dissociation of GDP by stabilizing the nucleotide-free state of the GTPases via their DH/PH domains; this facilitates binding of GTP and activation of the protein. The RGS subfamily of …
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Evaluation of Chronic RalGTPase Activation as a Core Specifier of Oncogenic Transformation
… via the Ras effector family Ral guanine nucleotide exchange factors (RalGEFs). Previous studies have demonstrated that RalA and RalB collaborate to maintain tumorigenicity through regulating both proliferation and survival. Remarkably, RalB is specifically required for survival in …
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Rab5 Activation by the Vps9 Domain
… the release of GDP and reloading of GTP. These nucleotide exchange factors contain additional domains which link them to specific cellular locations or signaling cascades. The multiplicity of these Rab5 proteins and exchange factors raises the question of how these proteins specifically interact …
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Analysis of The Biochemical and Cellular Activities of Substrate Binding By The Molecular Chaperone Hsp110/Sse1
… activity seen in Hsp70s. Hsp110s serve as Hsp70 nucleotide exchange factors (NEF) that facilitate the Hsp70 folding cycle by inducing release of protein substrate from Hsp70, thus recycling the chaperone for a sequential round of folding and allowing successfully folded substrates to exit the …
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Structure-function Analysis of the STRIPAK Complex
… interactors, including a family of guanine nucleotide exchange factors and protein phosphatase 6 (PP6).
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The Rac-GEF P-Rex1 Regulates Agonist-Induced GPCR Trafficking
P-Rex guanine-nucleotide exchange factors (GEFs) activate the small GTPase Rac following stimulation of a variety of cell surface receptors, including G protein-coupled receptors (GPCRs). By activating Rac, P-Rex proteins control gene expression, cell survival and motility, among other responses, …
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Localization and Function of Bacterial Type III and IV Effector Proteins
… time. Bacterial effector proteins are virulence factors that are directly secreted from the bacteria into the host cytosol and function to rewire eukaryotic signaling networks to establish an environment for bacterial survival. While much effort has gone into substrate identification and …
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R-RAS41A fusion protein purification and the cloning of a new RAS GEF like gene
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Regulation of Guanine Nucelotide Exchange in Inhibitory G Protein Alpha Subunit by Activator of G Protein Signaling 3 and Novel Regulatory Peptides
The release of GDP from the nucleotide binding pocket of G protein a subunit (Ga) is accelerated by guanine nucleotide exchange factors (GEFs) and inhibited by guanine nucleotide dissociation inhibitors (GDIs). The beta gamma subunit of heterotrimeric G protein and GoLoco motif are GDIs. Activator …
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Functional Analysis of Cytosolic Hsp70 Nucleotide Exchange Factor Networks In Yeast
… and Ssb, interact with up to three distinct nucleotide exchange factors (NEFs) homologous to human counterparts; Sse1/Sse2/HSP110, Fes1/HspBP1, and Snl1/Bag1. In an effort to understand the differential functional contributions of the cytosolic NEFs to protein homeostasis (“proteostasis”), I …
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Modulation of host phosphatidylinositol phosphates by salmonella effector protein SOPB
… 69% sequence identity are known to be guanine nucleotide exchange factors (GEFs). SopE is a GEF capable of activating both Rac1 and Cdc42 while SopE2 activates Cdc42 only. SopB is a known phosphatidylinositol phosphate phosphatase possessing both 4- and 5-phosphatase activities promoting …
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