Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 76 for “"nucleotide exchange"”.
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Functional Analysis of Cytosolic Hsp70 Nucleotide Exchange Factor Networks In Yeast
… and Ssb, interact with up to three distinct nucleotide exchange factors (NEFs) homologous to human counterparts; Sse1/Sse2/HSP110, Fes1/HspBP1, and Snl1/Bag1. In an effort to understand the differential functional contributions of the cytosolic NEFs to protein homeostasis (“proteostasis”), I …
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The Role of BiP Nucleotide Exchange Factor Sil1 in Immunoglobulin Biosynthesis
… members, cycles of BiP binding and release are nucleotide dependent and facilitated by two genres of cochaperones, HSP40s, and nucleotide exchange factors (NEFs). HSP40s function in stimulating the hydrolysis of ATP, which causes a conformational change that induces tight binding of BiP to …
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Regulation of rho guanine nucleotide exchange factors through lipid binding and phosphorylation
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-08-01
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Zyxin signaling: Protease-activated receptor-1 and Rho guanine nucleotide exchange factor p114.
… Protease-activated receptor-1 and Rho guanine nucleotide exchange factor p114.
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The Role of the Ras Guanyl-Nucleotide Exchange Factor Rasgrp1 in Synaptic Transmission
… Austausch Faktor (englisch: guanly-nucleotide exchange factor, GEF) und wird in hohem Maße im Hippocampus exprimiert. Viele andere GEFs und auch GTPase aktivierende Proteine (GAPs), die Ras Proteine regulieren, wurden schon auf ihre neuronale Funktion hin untersucht. Im Gegensatz …
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Invesitagating the role of the guanine nucleotide exchange factor P-Rex1 in cell invasion
… of the actin cytoskeleton. P-Rex1, a Rac guanine nucleotide exchange factor (GEF), was previously identified in this lab in a transcriptional screen for mediators of cell invasion. A number of GEFs have been shown to regulate the invasive phenotype of tumours and cancer cell lines, leading to the …
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Identification of a family of cAMP-binding guanine nucleotide exchange factors by Gregory M. Springett.
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1998.
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The WXXXE Effector Map Functions as a Potent and Specific Guanine Nucleotide Exchange Factor for CDC42
… of GTPase activating factors (GAPs) and Guanine Nucleotide Exchange Factors (GEFs). GAPs accelerate the intrinsic catalytic activity of the GTPase to physiologically relevant levels and lead to the rapid inactivation of a GTPase. GEFs conformationally eject bound GDP from inactivated GTPases …
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Identification and characterization of genetic interactors of the Rho Guanine-nucleotide exchange factor Pebble in <em>Drosophila</em>
… C-terminal tail might regulate or enhance the exchange activity of Pbl for Rac. The localization and function of Pbl depends on the PH domain and the C-terminal tail of Pbl. Both domains have distinct roles during Pbl function in mesoderm cell migration.
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Identification and Characterization of Novel Mechanisms of Functional and Structural Synapse Remodeling: Focus on Vav Guanine Nucleotide Exchange Factors and MEF2 Transcription Factors
… study, I identify a novel role for Vav guanine nucleotide exchange factors (GEFs) in brain-derived neurotrophic factor (BDNF)-dependent synapse plasticity. BNDF and its receptor, TrkB, are well-established positive modulators of hippocampal long-term potentiation (LTP), and increasing evidence …
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Receptor- G Protein Interactions in the Visual System: A Study of Structures and Mechanisms That Couple the Cytoplasmic Surface of Rhodopsin to the Nucleotide-Binding Pocket of Transducin
… rhodopsin (R*) activates Gt by catalyzing the exchange of bound GDP for GTP on its α subunit (Gα). The structure of the R*-Gt complex and the mechanism of nucleotide exchange are unknown. We studied the function of the fourth cytoplasmic loop (C4) of rhodopsin in interactions with Gt. Chimeric …
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Targeting the Rho1 GTPase signalling pathway in <i>Aspergillus fumigatus</i>
… GTPases and the upstream activation GEF (Guanine nucleotide exchange factor) proteins. Therefore, in this research I have identified a lead molecule that could be used to develop inhibitors against <i>Af</i>Rho1 and <i>Hs</i>RhoA by inhibiting the corresponding GEF proteins mediated nucleotide …
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Deciphering The Role of Hsp110 Chaperones In Diseases of Protein Misfolding
… class of molecular chaperones and acts as a nucleotide exchange factor (NEF) for Hsp70, the preeminent Hsp70-family protein folding chaperone. Hsp110 promotes rapid cycling of ADP for ATP, allowing Hsp70 to properly fold nascent or unfolded polypeptides in iterative cycles. In addition to its …
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Characterization of Tuba, a novel Ena/VASP ligand, and function of Ena/VASP proteins in mouse development
… proteins in vivo. Tuba is a unique guanine nucleotide exchange factor (GEF) for Cdc42 that binds dynamin and a number of actin regulatory proteins in addition to Ena/VASP proteins. A knockout of EVL was made to determine the requirement for EVL in mouse development. Genetic analysis of …
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Structure Based Drug Design of High Affinity Kras Inhibitors
… activation and son of sevenless (SOS) mediated nucleotide exchange. Moreover, treatment at low micromolar concentrations of compound 11 reduced cell proliferation in six cancer cell lines. Further, compound M1, binds to KRAS in NMR-based studies and both reduced and enhanced signaling in …
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The Src- and Abl- Dependent Regulation of Net1A In Breast Cancer
… transforming gene 1 (Net1) is a RhoA guanine nucleotide exchange factor that promotes cancer cell motility and metastasis. Two isoforms of Net1 exist, Net1 and Net1A, both of which are which sequestered in the nucleus in quiescent cells to prevent aberrant RhoA activation. Many cell motility …
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An investigation of the functional role of GRAB in the context of Rab3, Rab8 and Rab11
… which is an effector for Rab11a and a Guanine nucleotide Exchange Factor (GEF) for Rab8a. Rabin8 participates in a conserved Rab activation cascade which is critical in the formation of primary cilia. Data presented in this thesis has shown that GRAB interacts with Rab3a, Rab8a, Rab11a and …
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Regulation of Net1A Subcellular Localization By The Small Gtpase Rac1
… by a family of enzymes known as guanine nucleotide exchange factors (Rho GEFs). The neuroepithelioma transforming gene 1 (Net1) is a Rho GEF specific for the RhoA subfamily that is overexpressed in primary breast tumors and breast cancer cell lines. Net1 isoform expression is also …
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