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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"nucleotide analogs"”.
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The Synthesis and Studies of Some Adenine Nucleoside and Nucleotide Analogs
Made available in DSpace on 2014-12-10T23:00:55Z (GMT). No. of bitstreams: 1 7105227.pdf: 3677059 bytes, checksum: f0eb84f55cac8951f448deefba203a90 (MD5) Previous issue date: 1970
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Understanding the mechanism of antiretroviral nucleoside analogs as inhibitors of Epstein-Barr virus lytic DNA replication
… this thesis, we define the ability of nucleoside/nucleotide analogs licensed for the treatment of HIV to inhibit EBV lytic DNA replication in vitro. Using an established system of EBV lytic DNA replication in HH514-16 cells induced with butyrate, we validate azidothymidine (AZT) as an inhibitor of …
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Conformational Studies of Myosin and Actin with Calibrated Resonance Energy Transfer
… for structural studies of proteins and oligonucleotides. To study intramyosin distances, resonance energy transfer probes were attached to skeletal myosin's nucleotide site, subfragment-2, and regulatory light chain to examine nucleotide analog-induced structural transitions. The distances …
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Development of chemical probes for intracellular nucleotide delivery, profiling of the metabolic fate(s) of nucleoside monoester phosphoramidates, and a nucleotide mimetic inhibitor of eIF4E
… utility for delivery of significant levels of nucleotide analogs in tissues other than the liver. In order to broaden the utility of phosphate prodrugs, we have developed pronucleotide strategies that address the inefficiencies of the ProTide system. Chapter 2 describes the design and …
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Synthesis of Non-Natural Cyclic Di-Nucleotides for the Investigation of Bacterial Signaling Pathways
… This family of molecules, the cyclic di-nucleotides, which includes c-di-GMP and c-di-AMP, are critical to regulating bacterial processes such as motility, glucose remediation, and cell wall homeostasis. Their importance has spurred numerous investigations into their mechanism of action. …
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Novel molecular engineering approaches for genotyping and DNA sequencing
… of mass tagged, cleavable biotinylated dideoxynucleotides (ddNTP-N3-biotins) for DNA polymerase extension reaction and its application in DNA sequencing and single nucleotide polymorphism (SNP) genotyping by mass spectrometry. These nucleotide analogs have a biotin moiety attached to the 5 …