Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"nucleosome remodeling"”.
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DYNAMICS OF NUCLEOSOME REMODELING BY ATP-DEPENDENT CHROMATIN REMODELERS
… on DNA, break histone-DNA contacts, and mobilize nucleosomes. However, the final outcomes of nucleosome remodeling are diverse - nucleosome sliding, dimer exchange, nucleosome disassembly, and nucleosome conformation alteration. This study sheds light on how different chromatin remodelers catalyze …
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Role of Nucleosome Remodeling Factor (NURF) in Tumorigenesis Using a Breast Cancer Mouse Model
… they are potential targets for cancer therapy. Nucleosome Remodeling Factor (NURF) is a chromatin-remodeling complex that regulates gene expression by changing nucleosome positioning along the DNA sequence. Previous studies have shown a role for NURF in embryonic development as well as …
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Identification and Characterization of Hells-CDCA7, a Nucleosome Remodeling Complex Required for Mitotic Chromosome Structure
… I show that nearly all proteins involved in nucleosome assembly and remodeling are evicted from mitotic chromosomes, concurrent with a reduction in mitotic nucleosome assembly and discuss a role for these phenomena in shaping mitotic chromosomes. In analyzing my mass spectrometry data, I …
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The Role of the Nucleosome Remodeling and Histone Deacetylase (NuRD) Complex in Fetal γ-Globin Expression
<p>An understanding of the human fetal to adult hemoglobin switch offers the potential to ameliorate β-type globin gene disorders such as sickle cell anemia and β-thalassemia through activation of the fetal γ-globin gene. Chromatin modifying complexes, including MBD2-NuRD and GATA-1/FOG-1/NuRD play …
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Characterizing the role of Nucleosome Remodeling Factor (NURF) in tumorigenesis and metastatic progression using mouse models of breast cancer.
… Additionally, chromatin remodelers, such as the Nucleosome Remodeling Factor (NURF), have been identified as important regulators for normal cell biology. While much has been done to identify and characterize the role of NURF chromatin remodeling complex as a key regulator of development in a …
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THE MECHANISMS OF ISW1A, ISW1B AND ISW2 CHROMATIN REMODELERS
The focus of this study was to understand the nucleosome remodeling mechanism of three ISWI complexes in yeast using various biochemical approaches. The aspects investigated were, identification of the suitable substrate for ISW1a, role of accessory subunits and various domains/motifs of ISWI …
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STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE ISW2 CHROMATIN REMODELING COMPLEX
… energy derived from ATP hydrolysis to mobilize nucleosomes. ISWI remodelers mobilize and evenly space nucleosomes to regulate gene expression. ISW2, an ISWI remodeler in yeast, has been shown to reposition nucleosome near promoter regions and represses both mRNA and antisense non coding RNA …
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The synthetic multivulva genes and their suppressors regulate opposing cell fates through chromatin remodeling
… transcriptional repressors and chromatin-remodeling factors. The synMuv genes likely repress the transcription of the Ras pathway ligand lin-3 EGF. Some class B synMuv proteins are homologs of a Nucleosome Remodeling and Deacetylase (NuRD)-like complex and heterochromatin protein 1 (HP1). …
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Colocalization between Akirin, the NuRD Complex, and Histone Modifications
… remains unclear. Of the 4 major animal chromatin remodeling complexes, SWI/SNF, INO80, ISWI, and CHD, we know Akirin interacts with subunits of the SWI/SNF family Brahma (BRM) chromatin remodeling complex during myogenesis and cardiogenesis. Interaction between Akirin and CHD family chromatin …
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Investigation into the Akirin Subcellular Localization and Developmental Interactions
… the genetic interaction between Akirin and the Nucleosome Remodeling Deacetylase (NuRD) complex. Through transfection of <em>Drosophila</em> S2 cells with Akirin mutant constructs we were able to visualize the localization patterns of Akirin and how the patterns relate to the Nuclear …
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A role for the histone variant HTZ1 in meiotic chromosome segregation
… that are not well understood. These include nucleosome remodeling and post-translational modification of histone proteins (Dunn & Kingston, 2007; Kouzarides, 2007; Workman, 2006). An additional mechanism for chromatin regulation is the replacement of conventional histones with specific …
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Regulation and Function of Zeb1 Acetylation In Lung Adenocarcinoma Progression and Metastasis
… the acetylated form of ZEB1 recruits the nucleosome remodeling and deacetylase (NuRD) complex to bind the promoter of <em>mir200c-141</em> and <em>SEMA3F </em>genes. RNA-sequencing revealed that WT ZEB1 and K811Q ZEB1 downregulate the expression of epithelial genes to enhance NSCLC …
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Identification and functional characterization of the novel MAR-binding protein, SATB2
… the recruitment of histone-modifying enzymes or nucleosome-remodeling complexes, and the stimulation of RNA polymerase via an interaction with the mediator complex. In addition to enhancers and promoters, nuclear matrix attachment regions (MARs) have been implicated in the regulation of gene …
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ROLES OF ACCESSORY DOMAINS IN THE CATALYTIC SUBUNIT OF ISW2
… they coordinate with the ATPase domain during remodeling are not completely understood. Initial studies of SLIDE domain from our lab reveal its role in nucleosomal DNA propagation during remodeling process. In this study we focused on the SANT domain and found other mechanism of regulation that …
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SWI/SNF-NUCLEOSOME INTERACTIONS AND DISASSEMBLY OF NUCLEOSOMES: NOVEL METHODOLOGIES FOR MAPPING PROTEIN-PROTEIN AND PROTEIN-DNA INTERACTION
… Illinois University Carbondale. TITLE: SWI/SNF-NUCLEOSOME INTERACTIONS AND DISASSEMBLY OF NUCLEOSOMES: NOVEL METHODOLOGIES FOR MAPPING PROTEIN-PROTEIN AND PROTEIN-DNA INTERACTION MAJOR PROFESSOR: Dr. Blaine Bartholomew The SWI/SNF complex disrupts and mobilizes chromatin in an ATP-dependent …
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Resolving the Role of POU1F1 in Human Growth Hormone Locus Activation
… showed that DNA-bound POU1F1 interacts with the nucleosome remodeling complex subunit Brg1 and with the histone acetyltransferase GCN5. These observations provide the first direct evidence for HSI POU1F1-mediated cofactor recruitment in the distal activation of hGH-N by a chromatin-modification …
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The interaction of promoter chromatin architecture with the cell cycle regulates transcription activation kinetics
… sequences is an integral part of regulation, and nucleosome remodeling is often required for transcription activation. Though the transient response of these regulated genes is often important in biological contexts, the role of promoter chromatin architecture in activation kinetics is still …
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The Nucleosome Remodelling & Deacetylase complex: Genome folding & transcriptional regulation
… into a beads on a string like structure of nucleosomes. Until the advent of Chromosome Conformation Capture (3C), and related experiments, relatively little was known at scales between these two. In particular, the Hi-C experiment provides genome-wide pairwise information about the frequency …
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THE INTERPLAY OF HISTONE CHAPERONE NAP1 WITH SWI/SNF FAMILY OF CHROMATIN REMODELLERS IN S.cerevisiae
… ATP dependent chromatin remodelers remodel the nucleosomes. However nucleosome remodeling is also regulated by other factors like covalent modifications marks (methylation, acetylation etc. of both histones and chromatin remodelers). and histone chaperones. All these different players act in …
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MODES OF NUCLEOSOME INTERACTION AND MECHANISMS OF THE SACCHAROMYCES CEREVISIAE CHROMATIN REMODELERS INO80 AND ISW1A
… is largely governed by ATP-dependent chromatin remodeling complexes, which operate on nucleosomes in concert, to modulate chromatin structure and composition. Exchange of the canonical and variant forms of histones in nucleosomes, and altering the spacing between consecutive nucleosomes, are two …
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