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Showing 1 to 11 of 11 for “"nucleosome core particle"”.

  1. Biophysical Analysis of S100A12 and the Nucleosome Core Particle

    DiForte, Christopher, Jr.The Graduate School and University Center of The City University of New York2025

    … the calcium binding protein S100A12 and the nucleosome core particle. These studies are unified by a shared emphasis on how physical forces govern biological function.</p> <p>In the first part, we explore calcium mediated allostery in S100A12, focusing on the distinct roles of its two EF-hand …

    cuny-grad Repository record

  2. Structural and functional effects of histone variant, H2A.Bbd, on the nucleosome core particle

    Bao, Yunhe, author, Luger, Karolin, advisor, Anderson, Oren P., committee member, Laybourn, Paul J., committee member, Peersen, Ovle B., committee member, Stargell, Laurie A., committee memberColorado State University. Libraries2005

    … chromatin. The basic subunit of chromatin is the nucleosome core, which is composed of 147 base pair (bp) of DNA wrapped in 1.65 turns around a histone octamer containing two copies each of the four core histone proteins (H2A, H2B, H3 and H4). Chromatin creates an impediment to the processes of …

    colostate Repository record

  3. Determination of the trajectory of linker DNA by fluorescence energy transfer distance measurements

    Scherl, Dale S.University of Illinois at Urbana-Champaign2011

    … as it enters and exits the histone octamer in a nucleosome core particle. Measurement of the DNA-to-protein distances gives important structural information about the most fundamental level of chromosomal organization, and allows speculation about higher order compaction.

    uiuc Repository record

  4. Modulation of Cis-syn Cyclobutane Dimer Formation and Deamination at CpG sites by Nucleosome Particles and Its Implications for Deamination Bypass Mechanism for the Origin of C to T Mutations

    Song, Qian2013

    … of A opposite the resulting deaminated T.</p><p>Nucleosomes are the primary structural unit of chromatin in eukaryotic cells. UV preferentially induces the formation of CPDs in nucleosomes at sites where the phosphodiester backbone is positioned away from the histone surface and DNA bending is …

    wustl Repository record

  5. Molecular Modeling: Elucidation of Structure/Function Relationships of Proteins and DNA at the Atomic Resolution

    Ruscio, Jory ZmudaVirginia Tech2007

    … structures. Three biological systems, the nucleosome core particle, myoglobin and glycosyl hydrolase family 1 beta-glucosidases will be examined with molecular modeling methods. Results of our analyses provide information about DNA flexibility and packaging, internal migration of ligands in …

    vt Repository record

  6. REPAIR AND EFFECTS OF THE 8-OXOG LESION IN DNA

    Covino, James Joseph

    … unit within packaged eukaryotic DNA is the nucleosome core particle (NCP). The NCP consists of a 146 bp DNA fragment wrapped around an octamer of histone core proteins. Nucleosome core particle formation induces DNA structural changes and reduced DNA accessibility providing a very different …

    montana-tech Repository record

  7. REPAIR AND EFFECTS OF THE 8-OXOG LESION IN DNA

    Covino, James Joseph

    … unit within packaged eukaryotic DNA is the nucleosome core particle (NCP). The NCP consists of a 146 bp DNA fragment wrapped around an octamer of histone core proteins. Nucleosome core particle formation induces DNA structural changes and reduced DNA accessibility providing a very different …

    montana Repository record

  8. Cisplatin-induced nucleosome and RNA polymerase II modification mediate cellular response to the drug

    Wang, Dong, 1975-Massachusetts Institute of Technology2004

    … adducts at the physiologically relevant nucleosome level. Chapter 3: Nucleotide Excision Repair of Site-Specifically Platinum-Modified Tetrasomes. The nucleosome, the basic structural unit of chromatin, is composed of a histone (H3/H4)₂ tetramer flanked by two H2A/H2B dimers, around which …

    mit Repository record

  9. Characterizing interactions between cAMP responsive element binding protein 1 and methyl-CpG-binding protein 2 as a potential transcriptional activation complex

    Martinez, EsmeraldaThe University of Texas Medical Branch at Galveston2018

    … to methylated CpG dinucleotides and recruiting corepressors. Literature has shown that MeCP2 is also a transcriptional activator and has been proposed to bind directly to cAMP responsive element binding protein (CREB1) to facilitate this action. This hypothesis is under-studied biochemically, …

    utmb Repository record

  10. Characterisation of the (H3-H4)2-tetramer and its interaction with histone chaperones

    Bowman, AndrewUniversity of Dundee2010

    … resolution structures have been solved for the nucleosome core particle, there is limited information regarding the conformation of the core histones outside of chromatin. Insight into the structure of soluble histones, and the complexes they form, is likely to further our understanding of …

    dundee Repository record

  11. Structural and functional consequences of platinum anticancer drug binding to free and nucleosomal DNA

    Todd, Ryan Christopher, 1981-Massachusetts Institute of Technology2010

    … DNA modified by sitespecific platinum adducts. Nucleosome core particles containing a single 1,3-cis-{Pt(NH 3)2}2+_ d(GpTpG) intrastrand cross-link were synthesized and crystallized, and the X-ray structure was determined at 3.2 A resolution. The cisplatin adduct adopts a conformation facing …

    mit Repository record