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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 186 for “"nucleosome"”.

  1. Nucleosome repositioning in glioblastoma

    Koraka Folli, VarvaraUniversity of Essex2021

    … causes. In particular, the positioning of nucleosomes along the genome determines the accessibility of DNA to regulatory proteins and therefore modulates gene expression. In this project I investigate nucleosome positioning in relation to other features, such as transcription factor (TF) …

    essex Repository record

  2. Regulation of nucleosome dynamics

    Ngo, ThuyUniversity of Illinois at Urbana-Champaign2015

    … genome is packed into fundamental units called nucleosomes, where 147 base pairs of DNA are wrapped around a protein core. Stable packing of DNA in nucleosomes imposes a barrier for accessibility of genetic code on DNA for replication, transcription, and repair. The dynamics of nucleosomal DNA …

    uiuc Repository record

  3. Structural Studies of Crosslinked Nucleosome Core Particles

    Barth, PhilipETH Zurich2016

    ethz Repository record

  4. Statistical analysis and modeling of nucleosome positioning

    Jin, HuUniversity of Illinois at Urbana-Champaign2018

    Nucleosome is the fundamental building block of eukaryotic chromatin. The precise location of nucleosome along the genome plays a central role in gene regulation by controlling the accessibility of genetic information encoded in DNA. Understanding the principles underlying the establishment of …

    uiuc Repository record

  5. DYNAMICS OF NUCLEOSOME REMODELING BY ATP-DEPENDENT CHROMATIN REMODELERS

    Hada, Arjan

    … on DNA, break histone-DNA contacts, and mobilize nucleosomes. However, the final outcomes of nucleosome remodeling are diverse - nucleosome sliding, dimer exchange, nucleosome disassembly, and nucleosome conformation alteration. This study sheds light on how different chromatin remodelers catalyze …

    siu-theses Repository record

  6. Biophysical Analysis of S100A12 and the Nucleosome Core Particle

    DiForte, Christopher, Jr.The Graduate School and University Center of The City University of New York2025

    … the calcium binding protein S100A12 and the nucleosome core particle. These studies are unified by a shared emphasis on how physical forces govern biological function.</p> <p>In the first part, we explore calcium mediated allostery in S100A12, focusing on the distinct roles of its two EF-hand …

    cuny-grad Repository record

  7. The Nucleosome Remodelling & Deacetylase complex: Genome folding & transcriptional regulation

    Hall, DominicUniversity of Cambridge2022

    … into a beads on a string like structure of nucleosomes. Until the advent of Chromosome Conformation Capture (3C), and related experiments, relatively little was known at scales between these two. In particular, the Hi-C experiment provides genome-wide pairwise information about the frequency …

    cambridge Repository record

  8. Critical role of histone tail entropy in nucleosome unwinding

    Parsons, Thomas T. (Thomas Tyler)Massachusetts Institute of Technology2018

    … fundamental packaging unit for the genome, the nucleosome is of central importance for many essential biological processes and has been the focus of numerous research efforts. The dynamics of the nucleosome is of particular interest as it must be balanced to maintain long-lasting genome …

    mit Repository record

  9. Biochemical, biophysical and structural study of the nucleosome-MeCP2 complex

    Yang, Chenghua, author, Luger, Karolin, advisorColorado State University. Libraries2009

    … to understand the interactions between MeCP2 and nucleosomes, the fundamental component of chromatin. We used biochemical and biophysical approaches to study the interplay between MeCP2 and nucleosomes. Gel mobility assays showed that although MeCP2 can interact with a nucleosome with or without …

    colostate Repository record

  10. Molecular mechanisms of pioneer factor ELF2 interactions with the nucleosome

    Xiao, TianyiUniversity of Cambridge2024

    … of transcription factors (TFs) that can bind to nucleosomes and regulate gene expression at closed chromatin regions. Pioneer factors are important for stem cell pluripotency, cell reprogramming and differentiation. ETS family TFs are a large subfamily of TFs consisting of 29 members. The DNA …

    cambridge Repository record

  11. Characterizing ΔNp63α Binding Sites Based on Nucleosome Organization and Histone Modifications

    Tabrejee, ShamiraState University of New York at Buffalo2025

    M.S.

    buffalo Repository record

  12. Centromere Identity and the Nature of the Cenp-A-Containing Nucleosome

    Falk, Samantha Jane2016

    … centromere protein A (CENP-A) replaces H3 in nucleosomes at the centromere and is the best candidate to provide this epigenetic mark. This thesis aims to understand the features of the CENP-A nucleosome that impart its ability to mark and stabilize functional centromeres. In the first part of …

    penn Repository record

  13. Changes of nucleosome positioning and 3D chromatin organization in cell transitions

    Clarkson, ChrisUniverisity of Essex2020

    … chromatin. The basic unit of chromatin is the nucleosome. The positioning of nucleosomes on the DNA determines the accessibility of transcription factors (TFs) and other regulatory molecules. Beyond nucleosome positioning, the higher level of 3D chromatin architecture is constituted by …

    essex Repository record

  14. Structural and functional effects of histone variant, H2A.Bbd, on the nucleosome core particle

    Bao, Yunhe, author, Luger, Karolin, advisor, Anderson, Oren P., committee member, Laybourn, Paul J., committee member, Peersen, Ovle B., committee member, Stargell, Laurie A., committee memberColorado State University. Libraries2005

    … chromatin. The basic subunit of chromatin is the nucleosome core, which is composed of 147 base pair (bp) of DNA wrapped in 1.65 turns around a histone octamer containing two copies each of the four core histone proteins (H2A, H2B, H3 and H4). Chromatin creates an impediment to the processes of …

    colostate Repository record

  15. DISTINCT GENOME WIDE FUNCTIONS OF CHROMATIN REMODELERS IN NUCLEOSOME ORGANIZATION AND TRANSCRIPTION REGULATION

    Hailu, Solomon Ghebremeskel

    … GENOME WIDE FUNCTIONS OF CHROMATIN REMODELERS IN NUCLEOSOME ORGANIZATION AND TRANSCRIPTION REGULATION MAJOR PROFESSOR: Dr. Blaine Bartholomew Chromatin remodelers are conserved from yeast to humans and are the gatekeepers of chromatin. They regulate transcription by occluding or exposing DNA …

    siu-theses Repository record

  16. Nucleosome-independent permanently condensed chromosome: investigation of novel nuclear organisation in the dinoflagellates

    Hu, I IanUniversity of Cambridge2019

    … minimal histone proteins expression, and loss of nucleosome-mediated chromosome organisation. These changes co-occur with adoption of a novel nuclear protein termed DVNP (Dinoflagellate/Viral NucleoProtein). DVNP is highly positively charged, nucleus-located, and is found in only dinoflagellates …

    cambridge Repository record

  17. Role of Nucleosome Remodeling Factor (NURF) in Tumorigenesis Using a Breast Cancer Mouse Model

    Alhazmi, Aiman2017

    … they are potential targets for cancer therapy. Nucleosome Remodeling Factor (NURF) is a chromatin-remodeling complex that regulates gene expression by changing nucleosome positioning along the DNA sequence. Previous studies have shown a role for NURF in embryonic development as well as …

    vcu Repository record

  18. Cisplatin-induced nucleosome and RNA polymerase II modification mediate cellular response to the drug

    Wang, Dong, 1975-Massachusetts Institute of Technology2004

    … adducts at the physiologically relevant nucleosome level. Chapter 3: Nucleotide Excision Repair of Site-Specifically Platinum-Modified Tetrasomes. The nucleosome, the basic structural unit of chromatin, is composed of a histone (H3/H4)₂ tetramer flanked by two H2A/H2B dimers, around which …

    mit Repository record

  19. Evolution of nucleosome positioning and gene regulation in yeasts : a genomic and computational approach

    Tsankov, AlexMassachusetts Institute of Technology2010

    … gene expression by measuring mRNA abundance and nucleosome positions genome-wide in 13 Ascomycota yeast species. Our work introduces a host of new computational tools for studying chromatin structure, function, and evolution. We improved on existing methods for detecting nucleosome positions and …

    mit Repository record

  20. Contribution of histones to nucleosome stability, DNA accessibility, and higher order chromatin structures in yeast

    Fink, Michel FrancisETH2007

    ethz Repository record

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