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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 86 for “"nucleosides"”.
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Stereoselective synthesis of artificial C-nucleosides
… is the synthesis of lipophilic isosters of ribonucleosides for the RNA studies.
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Characterizing Modified Nucleosides in RNA by LC/UV/MS
… is to identify and quantify modified nucleosides in RNA using optimized LC/MS methods of analysis. This method was shown to be sufficient for characterizing changes in the abundance of modified nucleosides as a function of varying cellular conditions and can be used to explore the …
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Analysis of Nucleosides and Nucleotides in Milk and Infant Formula
… to measure the total potentially available nucleosides (TPAN) in human milk has made an important contribution to further understanding the distribution of nucleosides and nucleotides. This method was applied in a lactation study of bovine milk with colostrum and milk samples collected from …
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Molecule recognition of nucleic acids, nucleosides, nucleotides, and their derivatives
… DNA building units such as nucleotides, nucleosides, and nucleobases have recently aroused much interest because of their versatile applications. In chapter 5, we report the synthesis of calix[4]arenes ( 5.11-5.14 ) functionalized with a single nucleobase (thymine, adenine, guanine, or …
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The use of modified nucleosides as probes of macromolecular function.
Massachusetts Institute of Technology. Dept. of Chemistry. Thesis. 1974. Ph.D.
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Structural Investigations of High Molecular-Weight Antibiotics and of Epsilon-Nucleosides
Made available in DSpace on 2014-12-10T23:01:59Z (GMT). No. of bitstreams: 1 7500459.pdf: 6777996 bytes, checksum: 78e2ca28003be209e32510fd5bdd2635 (MD5) Previous issue date: 1974
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Novel approaches to the synthesis of selenium modified nucleosides, nucleotides and nucleic acids
… reaction conditions, 2ʹ-deoxy-5ʹ-O-tosylnucleosides reacted cleanly with potassium selenocyanate in refluxing acetonitrile. Following quenching of excess selenocyanate with benzyl bromide and column chromatography, pure materials were isolated. Three novel …
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Investigation of the Role of Groove Hydration and Charged Nucleosides in DNA Charge Transfer
… and thymidines by incorporating the modified nucleosides into anthraquinone linked DNA duplexes and irradiating them with UV light at 350 nm. The incorporation of these hydrophobic substituents disrupt the DNA spine of hydration, and we have observed that these modifications in the major and …
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Chemical synthesis of isotopically labelled (M+4) purine nucleosides and their incorporation into DNA oligomers
… Therefore, internal standards in the form of nucleosides and DNA oligomers are more desirable. After evaluating a number of methods, an enzymatic transglycolization technique was adopted for the transfer of the labelled bases to give their corresponding nucleosides. Both (M+4) 2-deoxyguanosine …
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Synthesis of 3'-deoxy- and 2',3'-dideoxy-4'-C-alkyl-D-nucleosides: potential antiviral agents
… of 3'-deoxy- and 2' ,3'-dideoxy-4' -C-alkyl nucleosides has been developed. The target nucleosides are of interest as potential antiviral agents. Crucial features addressed by the methodology are: the ability to synthesize nucleosides analogs with a variety on 4'-C-alkyl substituents; …
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Kinetic Studies of 6-Halopurine Nucleoside in SNAr Reactions; 6-(Azolyl, Alkylthio and Fluoro)-purine Nucleosides as Substrates for Suzuki Reactions
… for SNAr iodination of 6-chloropurine 2'-deoxynucleosides and nucleosides. Our studies demonstrate that 6-iodopurine nucleosides are excellent substrates for certain transition metal-catalyzed cross-coupling reactions. In chapter 2, we describe synthesis of protected 6-fluoro, 6-chloro, 6-bromo …
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Structure-aided design of inhibitors of Mycobacterium tuberculosis thimydilate kinase
… relationship by synthesising a series of nucleosides and nucleotides modified at the 2’-, 3’- and 5-positions of the dTMP-scaffold. These analogues were tested for their affinities for TMPKmt. From this, a 2'-chlorine and a 2'-fluorine substituent emerged as the most promising …
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Protein Specificity Dictates Proper Sulfur Transfer in the Biosynthesis of Thio-cofactors in Bacteria
… including iron-sulfur clusters, thio-nucleosides, and other thio-cofactors are critical players in several biological processes. The sulfur element present in these molecules is predominantly originated from L-cysteine through activation by cysteine desulfurases and is relayed to …
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Studies Toward A Detailed Understanding Of The Intrinsic Properties Of Nucleic Acid Constituents: Gas-Phase Conformations, Energetics, And Glycosidic Bond Stability
… forms of the nucleic acid constituents: nucleosides and mononucleotides, were characterized by infrared multiple photon dissociation (IRMPD) action spectroscopy and theoretical calculations. The IRMPD spectroscopy experiments were performed using a Fourier transform ion cyclotron …
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Synthesis and Spectroscopic Studies of Substituted Pyrrolocytidines
This thesis reports work in the area of modified nucleosides for potential use as molecular probes in nucleic acid chemistry. These heterocyclic base surrogates that are capable of canonical base pairing have use in the study of nucleic acid conformation, as reporters of the state of …
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Application of thermodynamic principles in biocatalytic synthesis of novel nucleoside analogues
Nucleosides and analogues thereof are central molecules in modern cancer therapy and in the fight against viral infections. However, their efficient synthesis is a challenging task for synthetic chemistry. This necessitates lengthy routes and results in low atom economy. Nature’s chemistry set, on …
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Synthesis of nucleoside analogues.
… as an intermediate to the synthesis of furan C-nucleosides. The key carbocyclic allylic alcohol intermediate 5-methoxymethylcyclopent-2-enol was synthesized via a six step synthesis in racemic form from the ethylene-acetal of 2-methoxymethylcyclopentanone but attempts at deprotection of the …
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