Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"nucleoside transporters"”.
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Structural and Functional Studies of Nucleoside Transporters
<p>Nucleoside transport is required for the salvage pathway of DNA and RNA, provides a transport route for nucleoside-like drugs and regulates adenosine signaling. The eukaryotic cell possesses two evolutionarily unrelated protein families of nucleoside transporters, the concentrative nucleoside …
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Computer-Aided Drug Design and Discovery, Screening and Synthesis of Small Molecule Inhibitors of Nucleoside Transporters
… analogue pharmacophore better predicted non-nucleoside small molecule inhibitors, and as such appears to be the better tool for aiding in the design of new small molecule inhibitors. The hCNT3 pharmacophore failed to select active compounds and as such must be redesigned. The hCNT1 …
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Flavonoids and Related Compounds as Nucleoside Transporter Inhibitors
<p>Mammalian nucleoside transporters can be classified into two main categories, namely, equilibrative nucleoside transporters (ENTs) and concentrative nucleoside transporters (CNTs). ENTs are ubiquitous, and mediate sodium-independent bi-directional facilitated diffusion nucleoside transport …
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Equilibrative Nucleoside Transporter Mediated Drug Disposition Across the Blood-Testis Barrier
… contraceptives and fertility treatments. Drug transporters present at the basal and apical membranes of testicular epithelial cells (Sertoli cells) facilitate the disposition of therapeutics across the BTB. Many antivirals and chemotherapeutic agents are classified as nucleoside analogs, which …
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Structure-Activity Relationship and Mechanistic Studies on the Chemopreventive Activity of Dipyridamole and Its Analogues
… novel chemopreventive agents and targets. The nucleoside transport inhibitor dipyridamole (<strong>DPM</strong>) showed potent chemopreventive activity against JB6 P<sup>+</sup>cells (tumor promotion sensitive). To probe the effects of <strong>DPM</strong> structural features on its antitumor …
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Molecular investigation if the rat jejunal active nucleoside transport protein rCNT1
Active, sodium-dependent nucleoside transport systems have been kinetically described in a number of different mammalian tissues. The recent cloning of several active, mammalian nucleoside transporters belonging to a novel gene family has provided an opportunity to examine both the …
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Design, Synthesis and Development of Transporter Targeting Agents For Image-Guided Therapy and Drug Delivery
… and GP could penetrate the cell membrane through nucleoside transporters and amino acid transporters, respectively. Up to 40% of intracellular <sup>99m</sup>Tc-N4amG and <sup>99m</sup>Tc-GP was found within cell nucleus following 2 hours of incubation. Flow cytometry analysis revealed …
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STRUCTURE-FUNCTION ANALYSIS OF THE HUMAN EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1
… domains 1 and 2 of the human equilibrative nucleoside transporter 1 (hENTl), in order to assess their contributions to transporter functionality. Through affinity changes in [ H]NBMPR binding, competitive inhibition profiles with ENT1 inhibitors and [ H]2- chloroadenosine uptake, these …
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Nucleos(t)ide Pathaways in the Placenta During Gestation and Preterm Birth:Nucleoside Effects and Drug Interference.
Placenta je zcela esenciální orgán pro vývoj plodu. Zajišťuje přenos živin a plynů, produkci hormonů a udržení imunitní tolerance a během těhotenství prochází dynamickými metabolickými adaptacemi podporujícími její růst a funkční integritu. Správný vývoj placenty vyžaduje přesně regulovanou …