Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"nucleoside analogs"”.
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Spectroscopic analysis and synthesis of nucleoside analogs for lethal mutagenesis
… to existing therapeutics. A novel antiviral nucleoside analog, 5-Aza-5,6-dihydro-2'- deoxycytidine (KP1212), employs the mechanism of lethal mutagenesis to avoid the problem of drug resistance and use the virus's high mutation rate against it. KP1212 is incorporated into DNA by HIV reverse …
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Synthetic and Computational Studies on Polycyclic Aromatic Hydrocarbon Derivatives, Nucleoside Analogs and Peptides
… derivatives, single electron oxidation nucleoside adducts and deoxynucleoside derivatives (Part 1). In Part 2 heterogeneous backbone oligomers containing the β-amino acid, trans-2-aminocyclohexanecarboxylic acid (ACHC), and α-amino acids Ala, Phe, Val, Lys, and Tyr in an alternating …
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Understanding the mechanism of antiretroviral nucleoside analogs as inhibitors of Epstein-Barr virus lytic DNA replication
… in this thesis, we define the ability of nucleoside/nucleotide analogs licensed for the treatment of HIV to inhibit EBV lytic DNA replication in vitro. Using an established system of EBV lytic DNA replication in HH514-16 cells induced with butyrate, we validate azidothymidine (AZT) as an …
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Synthesis of 3'-deoxy- and 2',3'-dideoxy-4'-C-alkyl-D-nucleosides: potential antiviral agents
… of 3'-deoxy- and 2' ,3'-dideoxy-4' -C-alkyl nucleosides has been developed. The target nucleosides are of interest as potential antiviral agents. Crucial features addressed by the methodology are: the ability to synthesize nucleosides analogs with a variety on 4'-C-alkyl substituents; …
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tRNA-dependent amino acid discrimination by Escherichia coli valyl-tRNA synthetase
… the conserved A76 with several different nucleoside analogs and measured their effect on the aminoacylation and editing activity of the tRNA.</p>
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Equilibrative Nucleoside Transporter Mediated Drug Disposition Across the Blood-Testis Barrier
… and chemotherapeutic agents are classified as nucleoside analogs, which resemble endogenous nucleosides essential for nucleic acid synthesis and spermatogenesis. Due to similarity in chemical structure, these drugs are suspected to be substrates of the equilibrative nucleoside transporters …
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Structures, Functions, and Druggability of the SARS-CoV-2 Replication–Transcription Complex
… into the nascent RNA, while antiviral nucleoside analogs must compete with the natural NTPs to be effective. How the SARS-CoV-2 RTC discriminates between the natural NTPs, and how antiviral nucleoside analogs compete, has not been discerned in detail. Therefore, I used cryo-electron …
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Targeting GRP78 in Cancer with Nucleic Acid Bioconjugates
… that may improve the pharmacology of a bioactive nucleoside. Moreover, this strategy has been proven to be effective with small molecule nucleoside analogs and those derived from lengthy oligonucleotide sequences. Considering these fruitful applications, my research and this thesis aims to explore …
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Proteindesign zur Verbesserung des Nucleosidanaloga-Umsatzes in menschlichen Zellen: Desoxycytidin-Kinase und UMP/CMP-Kinase
Die menschlichen Nucleosid- und Nucleosidmonophosphat-Kinasen spielen eine entscheidende Rolle bei der Aktivierung einer Vielzahl von Nucleosidanaloga, die in der Behandlung von Virus- und Krebserkrankungen eingesetzt werden. In dieser Arbeit wurden Enzyme untersucht, die limitierend für die …