Global ETD Search
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Showing 1 to 4 of 4 for “"nucleolar stress"”.
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Nucleolar Stress Due to Depletion of Nopp140 in Drosophila melanogaster
Nucleolar stress results when ribosome biogenesis is disrupted. An excellent example is the human Treacher Collins syndrome in which the loss of the nucleolar chaperone, Treacle, leads to p53-dependent apoptosis in embryonic neural crest cells, and ultimately to craniofacial birth defects. We show …
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The nucleolar protein NOC1 is essential for ribosome biogenesis, and its reduction activates a novel MYC-p53 axis mediating nucleolar stress
… relies on the coordinated action of numerous nucleolar proteins and RNAs; a crucial step in this mechanism is represented by rRNA processing and maturation. Defects in this process result in a condition known as nucleolar stress, a field of intensive studies for its relation with human …
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Nucleolar dynamics in cellular senescence
… been described, one of which is serving as a stress sensor. When the nucleolus senses stressors, it causes nucleolar stress characterised by changes to nucleolar area and function, along with signalling pathways including p53. Although alterations in nucleolar area were identified under …
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Re-thinking the role of ribosomal proteins in the Mdm2-p53 axis
… p53 through multiple mechanisms. However, when stress is encountered, this suppression is lifted and p53 transactivates the expression of many target genes to effect outcomes such as cell cycle arrest and apoptosis. One type of stress that can activate p53 is ribosomal stress, also called …