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Showing 1 to 20 of 61 for “"nucleobase"”.
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Design, Synthesis and Study of Novel Nucleobase Analogs
This thesis focused on nucleobase modified peptide nucleic acid (PNA) and DNA to expand the repertoire of available nucleobase analogs used in the study of nucleic acids. More specifically, we are interested in modification of the nucleobases such that they retain their ability to undergo …
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Nucleobase-modified deoxyribozymes for amide and peptide hydrolysis
… Chapter 2 describes the identification of nucleobase-modified deoxyribozymes for amide bond hydrolysis. By introducing protein-like functional groups in the nucleobases of deoxyuridines in DNA, amino, hydroxyl, and carboxyl modified deoxyribozymes were identified to catalyze the hydrolysis …
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Nucleobase deamination as a biomarker of inflammatory processes
… Moderate increases ([approximately]30%) in nucleobase deamination products were observed in the SJL mice bearing the RcsX tumor, but the biological meaning of these increases awaits studies of DNA repair kinetics. dO was not detected in any study at levels above 5 per 10⁸ nt, leading to the …
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Synthetic approaches to the understanding of DNA nucleobase methylation
DNA methylation is a major source of genetic variation and cancer. Methylation occurs when nucleophilic DNA bases react with methylating agent methyl methanesulfonate (MMS), dimethyl sulfate (DMS), N-methyl-N-nitrosourea (MNU), N-methyl-N-nitro-N-nitrosoguanidine (MNNG), etc. …
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Synthesis and Characterization of Nucleobase-Containing Polyelectrolytes for Gene Delivery
… a polyelectrolyte. Incorporation of the styrenic nucleobases significantly affected the solubility of these copolymers on aqueous solutions and showed salt-triggerability with higher contents of these groups. Polyelectrolytes are capable of binding and condensing DNA through electrostatic …
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Bio-inspired Design and Self-Assembly of Nucleobase- and Ion-Containing Polymers
Bio-inspired monomers functionalized with nucleobase or ionic group allowed synthesis of supramolecular polymers using free radical polymerization and controlled radical polymerization techniques. Comprehensive investigations for the structure-property-morphology relationships of these …
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Estudio de complejos de oro(I) y ligandos nucleobase hidrosolubles: propiedades ópticas e hidrogelificación
… de complejos mono- y dinucleares de oro(I) y la nucleobase natural adenina o las nucleobases tioladas artificiales 2-tiocitosina o 6-metil-2-tiouracilo, estabilizados con ligandos auxiliares de tipo fosfina. Se ha analizado con especial detenimiento la capacidad de hidrogelificación de los mismos …
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Nucleobase, Nucleoside, And Neighboring Nucleotides: Intrinsic Preferences For Tet Enzyme-Mediated Oxidation Of 5-Methylcytosine
The Ten-eleven-translocation (TET) family of enzymes can oxidize the fifth base of DNA, 5-methylcytosine (mC) sequentially, to 5-hydroxymethylcytosine (hmC), 5-formylcytosine (fC), and 5-carboxycytosine (caC). The biochemical preference of TET enzymes for these substrates, in the canonical cytosine …
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Synthesis and characterization of ammonium ionenes containing hydrogen bonding functionalities
… density. Non-covalent interactions including nucleobase hydrogen bonding and electrostatics were studied in ammonium ionenes. The non-covalent interactions are expected to increase the effective molecular weight of polymeric precursors and induce microphase separation due to intermolecular …
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Study Of Covalent And Non-Covalent Interactions In Ternary Systems Involving: Metal/DNA-RNA/Protein, Where Metal = Platinum(II), Palladium(II)
… function of each other.Monofunetional Platinum-nucleobase complexes (MPNs) are synthesized via substitution of a chloride ligand by a nucleobase in platinum complexes with trans geometry. MPNs are particularly interesting for the study of ternary systems since they mimic the first step in the …
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Non-Covalent Interactions in Block Copolymers Synthesized via Living Polymerization Techniques
Non-covalent interactions including nucleobase hydrogen bonding and ionic aggregation were studied in block and end-functional polymers synthesized via living polymerization techniques such as nitroxide mediated polymerization and anionic polymerization. The influence of non-covalent association on …
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Synthesis of gemcitabine and it's tetrafluorinated analogues
… 3,5-O-dibenzoyl-2- deoxy-2,2-difluororibose, the nucleobase moiety is constructed in a linear fashion, using amino- or urea glycosylation methodology. This methodology has also been employed to synthesise nucleosides containing a tetrafluorinated ribose sugar and has been compared to conventional …
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Synthesis of Novel 5-Aryl 2’-Deoxyuridine and 2’-Deoxycytidine Analogues
… of a phenyl ring at the C5 position of the nucleobase via a Suzuki-Miyaura cross-coupling reaction, yielding 5-phenyl-2’-deoxyuridine (5-PdU). After that, modification of the obtained 5-PdU at the C4 position was performed with benzotriazole-1-yl-oxy-tris-(dimethylamino)-phosphonium …
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Studies Toward A Detailed Understanding Of The Intrinsic Properties Of Nucleic Acid Constituents: Gas-Phase Conformations, Energetics, And Glycosidic Bond Stability
… regarding the preferred site of protonation, nucleobase orientation, and sugar puckering for each system investigated. </p> <p>Comparisons of the measured IRMPD spectra and the stable gas-phase conformations of DNA vs. RNA species allow the effect of the 2'-hydroxyl substituent on the IRMPD …
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Synthesis and Characterization of Cation-Containing and Hydrogen Bonding Supramolecular Polymers
Non-covalent interactions including nucleobase hydrogen bonding and phosphonium/ammonium ionic aggregation were studied in block and random polymers synthesized using controlled radical polymerization techniques such as nitroxide mediated polymerization (NMP) and reversible addition-fragmentation …
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Platinum Complexes and Zinc Finger Proteins: From Target Recognition to Fixation
… in cleavage. Monofunctional trans platinum-nucleobase complexes (MPNs) serve as a model for the binding of transplatin to DNA. This provides an interesting opportunity to study their reactions with S-containing proteins, such as HIV1 NCp7. MPNs have been shown to bind to the C-terminal ZF of …
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Expanding the Scope of T3 DNA Ligase-Catalyzed Oligonucleotide Polymerizations (T3-LOOPER)
… is to push the boundaries of LOOPER to tolerate nucleobase modified oligonucleotides, sugar modified oligonucleotides, modification positioning on the oligonucleotide sequence, RNA oligonucleotides, and reverse transcription via LOOPER of a modified nucleic acid polymer back to its DNA form. A …
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Designing Acrylic Block Copolymers with Multiple Hydrogen Bonding or Multiple Ionic Bonding
… hydrogen bonding interactions between nucleobase pairs in DNA, a series of bioinspired nucleobase-acrylate monomers such as adenine acrylate (AdA), thymine acrylate (ThA), cytosine acrylate (CyA) were designed, whose synthesis were afforded by aza-Michael addition. Among those …
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Molecule recognition of nucleic acids, nucleosides, nucleotides, and their derivatives
… units such as nucleotides, nucleosides, and nucleobases have recently aroused much interest because of their versatile applications. In chapter 5, we report the synthesis of calix[4]arenes ( 5.11-5.14 ) functionalized with a single nucleobase (thymine, adenine, guanine, or cytosine) at the …
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