Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"nucleic acid therapeutics"”.
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The Design, Synthesis, and Evaluation of Zwitterionic and Cationic Lipids for In Vivo RNA Delivery and Non-Viral CRISPR/Cas Gene Editing
The delivery of nucleic acids is an emerging therapeutic modality in clinical development for the treatment of many genetic diseases. The use of RNA interference (RNAi) as a therapeutic is an exciting and rapidly developing field that offers a promising alternative to small molecule drugs for the …
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DESIGN AND DEVELOPMENT OF RNA-BASED DRUGS USING MOLECULAR DYNAMICS SIMULATIONS AND ARTIFICIAL INTELLIGENCE METHODS
RNA-based therapeutics represent a powerful class of drugs offering precise targeting for genetic disorders, cancer, and infectious diseases. Several RNA-based modalities have been developed, including messenger RNAs (mRNAs), small interfering RNAs (siRNAs), microRNAs (miRNAs), antisense …
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Quantitative correlations among human mesenchymal stem cell mechanical properties and biological function
… with conventional small molecule/antibody/ nucleic acid therapeutics. However, all MSCs are not equivalent. Adult MSCs (aMSCs) derived from infant or adult sources are heterogeneous, exhibit poor overall integration in host tissues, and their differentiation and proliferation capacities are …
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Design, Synthesis, and Evaluation of Oleyl-WRH Peptides for siRNA Delivery
<p>The delivery of nucleic acid therapeutics across various cell membranes has always been one of the major challenges. Cell-penetrating peptides (CPPs) containing arginine (R), tryptophan (W), and histidine (H) have been promising for siRNA delivery. Therefore, to enhance siRNA delivery and …
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Functional Identification of MicroRNAs Counteracting Cellular Senescence
… further research may constitute a new class of nucleic acid therapeutics to combat tissue degeneration in ageing.
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Single-Molecule Characterization of RNA via Nanopore Sensing
… transcript analysis through the assembly of nucleic acid nanostructures directly from the RNA of interest, followed by characterization via solid-state nanopore sensing. I first describe the nanopore observables and nucleic acid parameters relevant to nanostructure characterization. Then, I …
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Granular Hydrogels for Localized Nanoparticle Delivery
… yet effective topical delivery of advanced therapeutics remains a major challenge. Nucleic acid–based therapies hold enormous promise for locally modulating gene expression and restoring skin homeostasis, but their translation is limited, among others, by the lack of simple, adaptable, and …
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Improving efficacy of therapeutics by enhancing delivery using chemical engineering
… decades, many new and interesting modalities for therapeutics have been discovered, including nucleic acid therapeutics such as siRNA and mRNA. However, one of the limiting challenges in developing these technologies into medicines is delivering the therapeutics to the correct location in the body …
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Development of Chemically-Defined Platform Materials for Localized Delivery of RNA Therapeutics
Most nucleic acid therapeutics have been engineered for systemic delivery with accumulation predominantly occurring in the liver. Currently, mRNA and siRNA represent the most clinically advanced nucleic acid modalities which can be used to address underlying under- or over-expression of crucial …
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Encoded synthesis and evolution of clinically approved 2'-modified ribonucleic acids
Xeno-nucleic acids (XNAs) are unnatural nucleic acids with altered sugar, phosphodiester backbone, or nucleobase components. 2'-modified nucleic acid chemistries, such as 2'-O-methyl-RNA (2'OMe-RNA) and 2'-O-2-methoxyethyl-RNA (MOE-RNA), have shown promise in clinical applications due to their …