Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"nucleic acid structure"”.
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Decoding the Fabric of Life: Nanopore Sensing of Nucleic Acid Structure from the Primary to the Quaternary
Nucleic acids exhibit a great variety of structures at all levels of organisation. These range from chemical modifications on nucleotides at the primary level through non-canonical tertiary structures like triplexes, and to quaternary structures such as naturally occurring ribosomes and …
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Electrophoretic Mobilities of Topoisomers of ΦX174 DNA
<p>The analysis of nucleic acid structure by zone electrophoresis in agarose gels has become an increasingly important method in studies requiring the separation and identification of species differing only slightly in molecular weight or conformation. We have demonstrated the existence of several …
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Polarizable Simulations of the bcl-2 DNA G-Quadruplex and FMRP RNA G-Quadruplex:Duplex Junction Binding Protein
A G-quadruplex (GQ) is a type of noncanonical nucleic acid structure that can form in regions of nucleic acids rich in guanine nucleotides. The guanine bases form a square planar conformation via Hoogsteen hydrogen bonding. These stacked tetrads have inward-facing carbonyl oxygens, facilitating the …
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Mechanical stability evaluation of i-motif and G-quadruplex structures under diverse circumstances
… is the most widely known four-stranded nucleic acid structure which has shown to alter gene regulation both in vitro and in vivo. Under certain conditions, another four-stranded structure, i-motif, is also formed in the strand complementary to the G-quadruplex forming sequence. Recent …
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Design, Synthesis and Study of Novel Nucleobase Analogs
… thesis focused on nucleobase modified peptide nucleic acid (PNA) and DNA to expand the repertoire of available nucleobase analogs used in the study of nucleic acids. More specifically, we are interested in modification of the nucleobases such that they retain their ability to undergo …
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RNA-binding Proteins and RNA-DNA Hybrids Regulate Repetitive DNA Stability in Health and Disease
… via RNA-DNA hybrids. RNA-DNA hybrids are duplex nucleic acid structures that form when an RNA molecule binds to its DNA template. RNA-DNA hybrids can generate a tri-nucleic acid structure known as an R-loop that is composed of the RNA-DNA hybrid and a displaced single-stranded non-template DNA. …
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A structural study of M-DNA
… The complex is thought to have a double helical structure that is similar to B-DNA. The presence of the divalent metal ions and a more compact structure may contribute to M-DNA’s remarkable ability to behave as a molecular wire. Because M-DNA is so similar to B-DNA, it adheres to the same rules …
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Genetic selection of cyclic peptide G-quadruplex ligands
… of chemical attempts to investigate biological structures for their function. Indeed, molecular probes that bind the G-quadruplex (G4) nucleic acid structure have been instrumental in demonstrating the existence and biological importance of these non-canonical secondary structures. There is …