Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"nucleic acid sensing"”.
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Cytosolic Nucleic Acid Sensing and Senescence in a Patient-Derived Model of Progressive Multiple Sclerosis
… Notably, interventions inhibiting the sensing of this mt-dsRNA in P-MS iNSCs attenuated senescence and innate immune activation, while also dampening the spread of pro- inflammatory responses. My findings suggest that mt-dsRNA serves as a crucial driver of senescence-associated …
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Regulation of Interferon Stimulated Genes Following Enveloped Virus Entry and Delivery of Viral Nucleic Acid
… receptors binding to virus-associated nucleic acid motifs, but virus activity may provide an additional means for the cell to recognize infection. Enveloped viruses fuse with a cell membrane during entry and membrane fusion by virus-like particles or the purified protein p14 are …
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DNA Walkers: Emerging Analytical Applications, Biomolecular-Nanomaterial Probes and Biomolecule Sensors
… a unique class of dynamic DNA devices that move nucleic acid walkers processively along designated one-, two-, or three-dimensional tracks. Because of the unique mechanical motion, dynamic interaction, and capabilities for signal amplification, programmable signal transduction, high …
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The Genetic, Molecular, And Cellular Bases Of Unidentified Primary Immunodeficiencies
… involved in cell migration, activation, and nucleic acid sensing to robustly protect us from virus infections without causing autoimmunity.
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Advanced nucleic acid detection with solid-state nanopores: from fundamental understanding to cutting-edge platforms
Solid-state glass nanopore sensing has emerged as a powerful technique for single molecule detection, due to its operational simplicity, high sensitivity, and real-time analytical capability. Despite these advantages, significant challenges remain in achieving multiplexed detection of diverse …
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Roles of Cytosolic Nucleic Acid Sensors in Cancer and Infection
… autoimmune diseases and cancer. Cytosolic nucleic acids including DNA and RNA originate from pathogens or self-cells, which form major groups of PAMPs and DAMPs. A range of nucleic acid sensors have evolved to sense various types of nucleic acids. How different DNA-sensing pathways regulate …
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Sensing Foreign DNA: The Role of DNA-PKcs in Human Anti-viral Innate Immunity
… major PAMP during DNA virus infection. Viral DNA sensing leads to the activation of the STING-TBK1-IRF3 signalling axis and the production of type I interferon. Previously, our work identified the non-homologous end-joining protein DNA-PKcs, part of the DNA-dependent protein kinase (DNA-PK) …