Global ETD Search
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Showing 1 to 7 of 7 for “"nucleic acid chemistry"”.
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Synthesis and Reactivity of Electroactive Carbon Sulfide Ligands and Studies on Modifications of Nucleic Acids
… study into the selective selenization of nucleic acid oligonucleotides was pursued. By using the soluble Se-transfer agent (i-PrC5H4)2TiSe5 in a new method with solid-phase phosphoramidite oligonucleotide synthesis, a mono-, di-, tri-, and tridecanucleotide of DNA with one …
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Synthesis and Spectroscopic Studies of Substituted Pyrrolocytidines
… for potential use as molecular probes in nucleic acid chemistry. These heterocyclic base surrogates that are capable of canonical base pairing have use in the study of nucleic acid conformation, as reporters of the state of hybridization.[1] The synthesis of a 5-phenylpyrrolocytidine was …
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Synthesis of oligonucleotide analogues for use in DNA nanostructures
… (CuAAC), the best known example of click chemistry, has proven to be of<br/>remarkably broad utility in synthetic chemistry and in nucleic acid chemistry in<br/>particular. CuAAC was exploited for the synthesis of a very stable double stranded<br/>catenane duplex. The catenane was formed …
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Development of functional DNA-based sensors and investigations into their mechanism
The discovery that nucleic acids could perform functional roles in addition to being genetic materials carriers opened doors to a new paradigm in nucleic acid chemistry. Catalytic DNA molecules also known as deoxyribozymes or DNAzymes were first isolated in 1994 through an in vitro selection …
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I. In vitro selection of aptamers for perchlorate and melamine II. Towards crystallization of DNAzymes III. A highly selective lead sensor based on a classic lead DNAzyme
Nature has given nucleic acids irreplaceable roles for all living creatures. It plays important roles in genetic information storage and transfer, as well as regulating various aspects of biology. The discovery of in vitro evolved functional nucleic acids opens a new field for nucleic acid …
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Encoded synthesis and evolution of clinically approved 2'-modified ribonucleic acids
Xeno-nucleic acids (XNAs) are unnatural nucleic acids with altered sugar, phosphodiester backbone, or nucleobase components. 2'-modified nucleic acid chemistries, such as 2'-O-methyl-RNA (2'OMe-RNA) and 2'-O-2-methoxyethyl-RNA (MOE-RNA), have shown promise in clinical applications due to their …
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In vitro selection and characterization of mono-, di-, and trivalent metal-dependent DNAzymes and their sensing applications
Since the discovery of nucleic acid enzymes and aptamers that can perform functional roles other than storing genetic information; a new paradigm in nucleic acid chemistry has been opened. In 1990 the first artificially isolated functional nucleic acid was discovered through an in vitro process …