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Showing 1 to 20 of 573 for “"nucleic acid"”.
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Nucleic acid biosensors
… volume element, as well as sophisticated nucleic acid sensors. A flow cell based microsphere platform (electronic tongue), and a novel hydrogel platform based on shape recognition elements (MUFFINS), have been combined with nucleic acid sensors (ssDNA and aptamers) and fluorescence …
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Chemical Studies on Nucleic Acid Analogues
Dicarbonyl aldehydes are known to react preferentially with guanine residues in both DNA and RNA; however, the exact structure of the modification product has never been assigned unequivocally as either the "linear" or the "bent" isomer. Accordingly, we have synthesized the products of guanine …
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Molecular recognition of nucleic acid components
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1992.
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An investigation into nucleic acid binding compounds
… with protein function; few drugs target the nucleic acid structures of DNA or RNA. Since these structures are underutilised as drug targets by comparison to proteins, it is desirable to design new antibiotics that target them. This allows new mechanisms of action to be explored and thus …
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Nucleic acid denaturation at an electrode surface
… the electrode surface. It was found that peptide nucleic acid (an uncharged analogue of DNA) could be denatured electrochemically. Local pH changes were also ruled-out as a possible mechanism through experiments in which the surface pH and electrochemical melting were monitored …
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Ribose nucleic acid and the cell nucleus
1. Methods of estimation of ribose nucleic acid are discussed and a reliable method for the estimation of that substance in isolated cell nuclei described.
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Programming Molecular Devices using Nucleic Acid Hairpins
<p>Nucleic Acid hairpins have been a subject of study for the last four decades. They are composed of single strand that is </p><p>hybridized to itself, and the central section forming an unhybridized loop. In nature, they stabilize single stranded RNA, serve as nucleation</p><p>sites for RNA …
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Nucleic acid-templated assembly of therapeutic agents
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01
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Silaffin Tagged Polymerase for Nucleic Acid Amplification
… (blood) when compared to more standard nucleic acid amplification diagnostic methods. In addition, this thesis initiates consideration of an extremely thermostable red fluorescent protein through structural analysis of mCherry and thermal green protein (TGP) for future integration with …
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Developing Nucleic Acid-Based Sensors and Actuators
… of regulatory logic in complex environments. Nucleic acids are attractive molecules for designing sense-and-respond modules: they are ubiquitous, information-rich and interact with each other through simple rules. Here, through two examples, I show that nucleic acids are particularly suited to …
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Artificial and natural nucleic acid self assembling systems
<p>Nucleic acids are good candidates for nanomachine construction. They participate in all the processes of life, and so can function as structural building blocks and dynamic catalysts. However, to use nucleic acids as nanomachines, a better understanding of their material properties, how to …
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Synthesis of Novel Cysteine Peptide Nucleic Acid (CPNA)
… birth to a new class of oligomers called Peptide Nucleic Acid (PNA). We herein report cysteine based PNA called CPNA.
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Targeting GRP78 in Cancer with Nucleic Acid Bioconjugates
<p>Nucleic acid bioconjugates have gained widespread use in medicinal chemistry research programs aimed at fighting human malignancies such as cancer, diabetes, genetic and infectious diseases. Their popularity stems from their ability to accelerate the drug development process by conjugating …
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Selective targeting to glioma with nucleic acid aptamers
The term glioma encompasses brain tumours arising from the glial cells. Malignant glioma are characterised by a rapid growth rate and high capacity for invasive infiltration to surrounding brain tissue, hence diagnosis and treatment is difficult, and patient survival is poor. Aptamers are small …
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Development of Field-deployable Nucleic Acid Testing Platforms
… focused on the development of field-deployable nucleic acid testing platforms to allowed rapid detection and quantification of nucleic acids. Two distinct platforms suitable for nucleic acid testing in resource-limited settings were developed. First, a paper-based diagnostic device was …
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Reactions of Diethyl-Pyrocarbonate With Nucleic Acid Components
Made available in DSpace on 2014-12-10T23:01:36Z (GMT). No. of bitstreams: 1 7317556.pdf: 3166447 bytes, checksum: 8c9a77aded76ad454fcf6c18fc3b6051 (MD5) Previous issue date: 1973
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Hydrodynamic Studies of Nucleic Acid and Virus Structure
Made available in DSpace on 2014-12-09T17:36:10Z (GMT). No. of bitstreams: 1 6910688.pdf: 3930019 bytes, checksum: cd5b363710bcde64c716fb23188ce63c (MD5) Previous issue date: 1968
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Enzymatic Steps in Protein and Nucleic Acid Biosynthesis
Made available in DSpace on 2014-12-05T21:45:28Z (GMT). No. of bitstreams: 1 0023376.pdf: 3360047 bytes, checksum: 31600ec6454facba9a462963bd0443e7 (MD5) Previous issue date: 1957
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Solid-state nanopore sensors for nucleic acid analysis
Nanopore DNA analysis is an emerging technique that involves electrophoretically driving DNA molecules through a nano-scale pore in solution and monitoring the corresponding change in ionic pore current. This versatile approach permits the label-free, amplification-free analysis of charged polymers …
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