Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 127 for “"nuclear translocation"”.
-
Nuclear Translocation of Met Via Internet Mechanism
… peroxide (H<sub>2</sub>O<sub>2</sub>) can induce nuclear translocation of full-length MET holoreceptor via a membrane-bound vesicle transport mechanism in breast cancer cells. Our findings provide a putative mechanism by which breast cancer cells adapt to oxidative stress.</p>
-
Nuclear translocation of Gasdermin D (GSDMD) sensitizes chemotherapy through inhibiting PARP-1 in colorectal cancer
… characterized. In my dissertation, I found GSDMD nuclear translocation and the apoptotic role of GSDMD for the first time. My first objective was to explore the correlation between the nuclear localization of GSDMD and overall survival rate of colorectal cancer patients. To address my first …
-
Syntaxin 6- and Microtubule- Mediated Intracellular Trafficking Contributes to Golgi and Nuclear Translocation of Egfr
… understood. Here we report a mechanism of Golgi translocation of EGFR in which EGF-induced EGFR travels to the Golgi via microtubule (MT)-dependent movement by interacting with dynein and fuses with the Golgi through syntaxin 6 (Syn6)-mediated membrane fusion. We also demonstrate that the Golgi …
-
Control of proliferation in human mesenchymal stem cells by Secreted Frizzled Related Protein 1
… This study confirmed that RORα expression and nuclear translocation were increased in late passage of hMSCs. Also, MSC/shRORα showed promoted growth kinetics, indicating that RORα could be a negative regulator of hMSCs’ proliferation. To figure out whether sFRP1 inhibits nuclear translocation …
-
Deciphering the mechanism by which humanin binding to IGFBP3 inhibits neuronal cell death in alzheimer’s disease
<p>Nuclear translocation of IGFBP3 by importin β1 is a prerequisite for apoptosis induced by IGFBP3 in Alzheimer’s disease (AD). The neuroprotective peptide humanin (HN) counteracts this IGFBP3-induced cell death. Unfortunately, the natural synthesis of this peptide decreases with age coincident …
-
Functional role of GSK3β in p38MAPK mediated human amnion membrane senescence
… roles. GSK3β inactivation was associated with nuclear translocation of antioxidant nuclear factor erythroid 2–related factor 2 (Nrf2) and exosomal section of β-catenin. OS-induced P-p38MAPK activation is associated with functional down regulation of GSK3β and arrest of cell cycle progression …
-
The functional motifs for nucleocytoplasmic shuttling of C-terminal fragment of c-Met : A novel "pH-dependent' nuclear localization signal
… specific amino acid motif nor the responsible nuclear localization signal (NLS) has not been previously reported. Here, we report that two histidine residues separated by a 10-amino-acid spacer (H1068-H1079) located in the juxtamembrane region of c-Met function as a putative novel NLS. …
-
Regulation of Energy Metabolism by Fructose in the Liver
… ChREBP activation occurs in the nucleus after nuclear translocation of ChREBP in F-fed rat.
-
IL-1 activation of NF-kB contributes to perinatal hypoxia/ischemia induced cell death
… immunofluorescent staining showed significant nuclear translocation of p65. Protein expression levels of iNOS and COX2, known to be transcriptionally regulated by NF-kB, also increased at 24h post-HI. All these changes were reversed by IL-1Ra blockade of IL-1, consistent with IL-1 triggering of …
-
Cellular and Molecular Mechanisms Involved in the Induction of the Lipostatic Cytokine Leptin by Tumor Necrosis Factor Alpha
… expression and prevented the increase in C/EBP nuclear translocation that was stimulated by TNFalpha treatment. Finally, it was found that pretreatment with peroxisome proliferator-activated receptor ligands could significantly ameliorate inflammatory hyperleptinemia without affecting …
-
Activation of the Transient Receptor Potential Vanilloid-1 (TRPV1) channel mediates Extracellular Signal Regulated Kinase (ERK) phosphorylation via Beta-arrestin-2 signaling
… calcium influx through TRPV1 channels induced translocation of β-arrestin-2 from the cytosol to the nucleus. In addition, we showed that TRPV1 activation elicited ERK phosphorylation in a β-arrestin-2-dependent manner. Our data suggest that the signaling cascade starts with calcium influx …
-
Analysis of nuclear transport signals of the human apurinic/apurimidinic endonuclease (APE1/REF1)
The nuclear localization signal (NLS) in human apurinic/apyrimidinic endonuclease (APE1), a key protein in both DNA base excision repair and transcriptional regulation, has not been analyzed in detail. We examined the role of specific residues in nuclear translocation of APE1, using green …
-
Signal transduction pathways involved in skeletal muscle fibre type regulation
… were investigated using western blotting. The nuclear translocation kinetics of NFAT and NF-icB in response to treatment with the calcium ionophore A23187 were investigated in L6 myotubes using immunocytochernistry. Calcineurin blockade using cyclosporin A failed to prevent a decrease in …
-
The Role of Lipoprotein(a)/Apolipoprotein(a) in Endothelial Dysfunction: Mechanistic Studies in Vascular Endothelium
… PI3K/Akt/GSK3β-dependent pathway to facilitate nuclear translocation of beta-catenin. In the nucleus beta-catenin induced the expression of cyclooxygenase-2 (COX-2) and the secretion of prostaglandin E2 (PGE2) from the EC. Finally, we have presented data to suggest a novel inflammatory role for …
-
Functional analysis of murine CD43 shedding : a role for the CD43 cytoplasmic tail in nuclear signalling
… for release of the cytoplasmic domain and its translocation to the nucleus. In support of our hypothesis, we confirmed that the CD43 cytoplasmic domain is localized in the nucleus and is modified by SUMO (small ubiquitin-like modifier) peptides. In an attempt to determine the functional …
-
Innate immune evasion and interferon antagonism by porcine epidemic diarrhea virus
… did not interfere the IRF3 phosphorylation and nuclear translocation upon stimulation but interrupted the enhanceosome assembly of IRF3 and CREB-binding protein (CBP) by degrading CBP. The CBP degradation by nsp1 was proteasome-dependent. We further showed that PEDV inhibited both NF-κB and …
-
New Insights On The Role of Jmjd2A In Cancer Progression
… signaling cascade that ultimately leads to nuclear accumulation of β-catenin. Nuclear β-catenin serves as a transcriptional coactivator by forming a transcriptional complex with TCF to activate Wnt target gene expressions. The presence of JMJD2A keeps β-catenin from interacting with the …
-
Regulation of Cardiomyocyte Proliferation by microRNAs and Small Molecules
… miRNAs activated YAP-mediated transcription, nuclear localization of active YAP and increased expression of YAP responsive genes. Of notice, miR-199a-3p, one of the most effective miRNAs exerted its direct effect on two mRNA targets impinging on the Hippo pathway, the inhibitory kinase TAOK1 …
-
A Structural and Biochemical Analysis of the Drosophila Protein Period
… production, posttranslational modification, and nuclear translocation of PER all contribute to the timing of the clock. This work describes the synthesis and purification of various Drosophila PER fragments for biochemical and crystallographic analysis. Several stable PER fragments are …
-
Effects of scriptaid on osteocytes skeletal homeostasis and metabolic functions
… inhibitor of bone formation) by inducing HDAC4/5 nuclear translocation and MEF2C inhibition. Recently, Scriptaid, an HDAC complex inhibitor, has been shown to induce Mef2 expression and exercise-like adaptation in mouse muscles. In myocytes, Scriptaid disrupts the HDACs co-repressor complex and …
Page 1 of 7