Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"nuclear signaling"”.
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Constitutive activity in orphan G protein coupled receptors
<p>"The goal of this research was to use a distal signaling pathway analysis to evaluate the extent of agonist independent constitutive signaling among orphan class-A G protein coupled receptors (GPCRs). These receptors translate extracellular signals via conformational change into intracellular …
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Influence of Sodium Channel Activation on NMDA Receptor-Mediated Structural Plasticity.
… N-methyl D-aspartate receptor (NMDAR)-dependent signaling mechanisms. Inasmuch as neuronal activity involves activation of voltage-gated sodium channels (VGSCs) primarily, in this study, we used a sodium channel activator, brevetoxin-2 (PbTx-2) to mimic neuronal activity. Brevetoxins interact …
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Predicting angiogenic receptor trafficking and signaling via computational systems biology
… complex formation implies a possible VEGFR1 signaling role beyond its classically defined decoy status. In this dissertation, I introduce a computational approach that accurately predicts the cell response elicited via VEGFR1 signaling. I show that VEGFR1 promotes cell migration through PLCγ …
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Unintended Survivability: Comparative Reactions to Israel's Nuclear Posture
… regional perspectives on the impact of Israel's nuclear monopoly on nuclear decisions in the Middle East. This Dissertation addresses the question as to why regional actors have taken divergent nuclear paths relative to Israel's nuclear posture. The point of departure for this inquiry is whether …