Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 77 for “"nuclear receptors"”.
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Nuclear Receptors in Lung Cancer
… information by studying of the expression of the nuclear receptor (NR) superfamily in lung cancer. Using quantitative real-time PCR, mRNA expression levels for the 48 members of the NR superfamily were profiled in 56 lung cell lines. Based on the resulting dataset, further analysis was performed …
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The Opsins and Nuclear Receptors of the Honey Bee
… the first genome-based overview of the nuclear receptors of Apis mellifera. I found a striking conservation in the number of nuclear receptor genes between the honey bee and Drosophila, suggesting the prevalence of an essential set of nuclear receptors and their functional conservation …
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Bile Acids and Nuclear Receptors: Their Roles in Nutrition and Cancer
… Finally, vitamins A and D were found to activate nuclear receptors in the intestine and repress bile acid synthesis. These results underscore the role of nuclear receptors and their ligands in maintaining intestinal homeostasis and in protecting against the tumor- promoting effects of bile acids.
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Chemical Tools for Exploring Metabolite Interactions with Nuclear Receptors and Beyond
… probe (alk-GW9662) for a subset of nuclear receptors (NRs). NRs are a family of ligand-activated transcription factors that regulate diverse physiological processes in animals and are key targets for therapeutic development. Recent studies implicated NRs in host–microbiota …
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Investigating the Regulation and Function of the NR4A Nuclear Receptors in Cancer
<p>The nuclear receptor (NR) superfamily represents a structurally-conserved group of ligand-regulated transcription factors. These proteins have critical roles in various physiological and pathological processes, including cancer, and have been targets of drug therapy. The orphan NR subfamily 4A …
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Key role and diversity of EcR/USP and other nuclear receptors in selected Arthropoda species
The nuclear receptors (NRs), an important protein superfamily of transcription factors found in all animals, regulate the expression of genes in a large array of biological processes. Their involvement in moulting and metamorphosis, embryonic development, cell differentiation and reproduction of …
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The roles of orphan nuclear receptors, SHP and FXR, and their cofactors in bile acid signaling
… poorly understood. In recent years, two orphan nuclear receptors, farnesoid X receptor (FXR) and small heterodimer partner (SHP), have been identified as key regulators in bile acid signaling. FXR was revealed as the first in vivo bile acid biosensor and was shown to regulate cholesterol/bile …
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Porcine model of xenobiotic metabolism
… of xenobiotics introduced into the body. Orphan nuclear receptors play crucial role in regulation of the expression of DMEs. The pig has quickly grown into an important biomedical research tool over the past few decades. The pig is an appropriate animal model for the investigation of xenobiotic …
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Age-Associated Hepatic Drug Transporter Expression and Its Implications for Pediatric Pharmacotherapyflexibility affect DNA topoisomerase I function
… we also characterized the ontogeny of four nuclear receptors through measurement of their gene expression. Nuclear receptors belong to a highly conserved gene superfamily of transcriptional factors that regulate the expression of their target genes, many of which include members of the ABC …
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The Regulation of Cholesterol Absorption: Nuclear Hormone Receptors and Niemann-Pick C1 Like 1
… brush border. In addition, members of the nuclear receptor superfamily of ligand-activated transcription factors are known to modulate expression of genes involved in cholesterol and bile acid homeostasis, and cholesterol absorption. Therefore, we wanted not only to clarify the essential …
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THE ROLE OF EPIGENETICS IN TRANSCRIPTIONAL REGULATION OF FXR AND SILENCING FXR EXPRESSION IN HUMAN COLON CANCER
… activated transcription factor belonging to the nuclear receptor superfamily and bile acids are its endogenous ligands. FXR is a critical regulator of the enterohepatic circulation of bile acids, lipid homeostasis, glucose metabolism, and tumor suppression in liver and intestine. Consequently, …
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Evolutionary analysis of mammalian genomes and associations to human disease
… spurred an in*depth evolutionary analysis of the nuclear receptors, a family of transcription factors. 12 of the 48 nuclear receptors were found to be under positive selection in mammalia. The androgen receptor was found to have undergone positive selection along the human lineage. Positively …
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Characterization of the FTF/HNF-4 Sites Within the 7Alpha- and the 12Alpha-Hydroxylase Promoters Involved in the Bile Acid-Mediated Transcription of their Regulation
… expression of 7α- and 12α-hydroxylase genes are nuclear receptors.One of the first nuclear receptors identified to play a role in the transcription of the 7α-hydroxylase gene was HNF-4 since then many nuclear receptors have been identified that are involved in regulating the 7α- and …
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MicroRNAs: Tissue Expression and Role in 3T3-L1 Pre-Adipocyte Differentiation
… of the expression of microRNAs with that of nuclear receptors in mouse tissues showed positive correlations between a select number of nuclear receptors and microRNAs, but these relationships need to be verified by experimental data. In all, the expression profile of microRNAs in mouse …
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Isolation and Characterization of Estrogen Receptor- Interacting Proteins
… a variety of physiological roles through its nuclear receptors, estrogen receptors (ERs). The action of ERs is modulated and mediated by diverse interacting cofactors. The initial aim of this thesis work was to identify ligand-, subtype- and/or cell typespecific ER-interacting proteins. I …
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Integrated strategies for investigating endocrine mechanisms in Biomphalaria Glabrata as a test organism for androgenic chemical testing
… an exhaustive investigation on the mollusc nuclear receptor repertoire and reproductive type neuropeptides was conducted. This also included the study of the evolutionary degree of conservation of these genes in non-model molluscs. The results obtained suggest that the snails did not respond …
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Small-molecule inhibition of general transcriptional regulators in cancer
… for cancer therapy has thus far been limited to nuclear receptors. Recent studies, however, have suggested that inhibitors of various general transcriptional regulators can be used in cancer therapy because expression of some oncogenes is disproportionately sensitivity to these inhibitors. Here, …
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