Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 61 for “"nuclear proteins"”.
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DNase 1 hypersensitive sites in rabbit cytochrome P-450IIC subfamily genes and binding of liver nuclear proteins
… by the interaction of trans-acting regulatory proteins with cis-acting DNA elements of a gene. Therefore, to elucidate the mechanism of gene regulation of the P450IIC genes, identification of cis-acting regulatory elements in the P450IIC genes and the corresponding trans-acting factors is …
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COMPARATIVE PROTEOMICS STUDIES OF SOLUBLE NUCLEAR PROTEINS OF DRUG SUSCEPTIBLE AND RESISTANT HUMAN BREAST CANCER MCF-7 CELLS
… of the cancer cells, differential expression of nuclear proteins may play crucial roles as cancer cells acquire drug resistance. Thus I have carried out a comparative proteomics research project to study differential expression of nuclear proteins in drug resistant human breast cancer MCF-7 …
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Non-Histone Nuclear Proteins : Patterns of Synthesis and Phosphorylation During the Cell Cycle, Redistribution at Times of Gene Activation and Properties of Subsets Interacting with HnRNA
… nucleus contains large numbers of nonhistone proteins, the majority of which are associated with chromatin. The amount and number of these proteins varies according to cell type. Actively proliferating cells with high transcriptional activity contain considerably more nonhistone nuclear …
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Photo-cross-linking and identification of nuclear proteins that bind to DNA containing a site-specific adduct of cis-[Pt(NH₃)(N-6-aminohexyl)-4-benzophenonamide)CI₂]
… toxic to cells if not repaired. By identifying proteins that bind to platinum-modified DNA, the work in this thesis focuses on the early stages of DNA adduct processing. The first chapter of this thesis gives a review of the identification of proteins with an affinity for platinum-modified DNA …
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Molecular analysis of wheat snRNAs
… particles (snRNPs), formed from small nuclear RNAs (snRNAs) and their associated nuclear proteins.
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Regulation of expression of the human interleukin 3 gene / by Gregory Robert Ryan.
… and partial characterisation of a number of nuclear proteins which bind specifically to regulatory elements in the IL-3 promoter.
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Analysis of the nuclear proteome of the resurrection plant Xerophyta viscosa (Baker) and its response to dehydration stress
… In this respect a comprehensive analysis of the nuclear proteome of this plant and its response to dehydration stress at 35% RWC was carried out. The RWC at 35% represents a distinct phase of the dehydration process where induction of late protection mechanisms is initiated and is a …
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Histone/Serum Protein interactions, A cause of Pseudoimmunological reactions
… have been described by Murray (1964) as basic nuclear proteins which are at some time associated with DNA. Reviews on the biochemistry of histones have been written by Phillips (1962), Busch (1965 ), Butler, Johns and Phillips (1968), Hnilica (1967) and Bonner, Dabrnus, Fambrough, Huang, …
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Transcriptional Regulation of Promoters Containing Different Estrogen Response Elements
… of receptor conformation. Interestingly, nuclear proteins from ERalpha-containing MCF-7 breast cancer cells formed different complexes with DNA fragments containing the A2, pS2, B1, or OT ERE in gel mobility shift assays suggesting that ERE-induced receptor conformation may dictate which …
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Transcriptional regulation of basal and phenobarbital-mediated expression of rat cytochrome 2B genes
… by transfection in HepG2 cells and by binding of nuclear proteins. Deletion of sequences from $-$110 to $-$57 markedly decreased the transcriptional activity, suggesting the presence of strong cis-acting elements in this region. Sequences similar to a basal transcription element (BTE), and a …
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Identifizierung und Charakterisierung von Interaktionen der Nichtstrukturproteine NS1 und NS2 des Respiratorischen Synzytialvirus mit Proteinen der Wirtszelle
… Syncytial Virus (RSV) encode two nonstructural proteins, NS1 and NS2. These two proteins cooperatively mediate type I interferon resistance and prevent induction of interferon in infected cells. Interactions of NS1 and NS2 proteins in every combination were shown by using the yeast-two-hybrid …
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The Mapping of Transcription Factor Binding Sites in the Turkey Prolactin Gene
… mobility shift assay (EMSA) using nuclear extracts from turkey pituitaries and liver. Within this 2 kb fragment, only three regions of the tPRL gene were identified that participate in tissue- and sequence-specific DNA-protein interactions with nuclear extracts from turkey …
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MOLECULAR BIOLOGY OF HEPATITIS B VIRUS DNA-CELL INTERACTION
… of HBV replication may be dependent on such nuclear proteins is indeed intriguing and would certainly help to better understand and give insight into the steps leading to HBV pathogenesis.
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Nitric oxide induces chromatin remodelling in the developing central nervous system
… inducing Snitrosylation of a wide array of nuclear proteins. S-nitrosylation of histone deacetylase 2 (HDAC2) decreases its affinity for chromatin, leading to increased histone acetylation levels. This NO-dependent regulation of HDAC2 promotes changes in endogenous gene expression and …
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Regulation of mitotic exit in Saccharomyces cerevisiae
… fork block protein Fobl, and the small nuclear proteins Spol2 and Bnsl. Genetic epistasis analyses revealed that the FEAR network consists of at least two branches. ESPI and SLK19 function in parallel to SP012 and FOBI. I then characterized the Spol2-Fobl branch in detail. My results …
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Phosphoproteins of the Cell Nucleus: Metabolism and Characterization
… chemistry and metabolism of the phosphorylated proteins which are found localized in cell nuclei. The studies focus first on phosphoprotein metabolism as it occurs in the intact nucleus under varying conditions, and then on the chemistry and enzymology of a phosphoprotein fraction which has been …
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Analysis of DIE5 and LIA5 reveals the importance of DNA repair in programmed DNA rearrangement of Tetrahymena thermophila
<p>During its somatic nuclear differentiation, the single cell eukaryote Tetrahymena thermophila undergoes genome-wide programmed DNA rearrangement to eliminate transposon-like elements from its future soma. This process involves small RNA-directed heterochromatin formation followed by extensive …
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Retinoic Acid Regulation of Thyroid Hormone Action in Bone Cells
… thyroid hormone in chondrocytes by influencing nuclear proteins that are recruited to the thyroid hormone receptor complex. In conclusion, our findings suggest that the effect of retinoic acid treatment appears to be complex involving both stimulation and inhibition of differentiation depending …
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