Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"nuclear localisation signal (NLS);"”.
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Novel plant nuclear envelope-associated coiled-coil proteins
The nuclear envelope (NE) is a double lipid bilayer enclosing the eukaryotic genome. The metazoan nucleoskeleton includes the peripheral lamina and the internal nucleoskeleton. The lamina is composed of a network of intermediate filament (IF) proteins called lamins, as well as lamin- and/or …
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LNX1 and LNX2 in the central nervous system: linking behavioural, cellular and molecular perspectives
… that identified and characterised a functional nuclear localisation signal (NLS) within both LNX1 p80 and p70 isoforms, which is absent in LNX2. This finding partially explains why LNX1 localises to the nucleus upon transfection, whereas LNX2 remains largely cytoplasmic. Bioinformatic analysis …
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Regulation of human protein kinases and phosphatases by 14-3-3
… with PP2A. Rather, binding of 14-3-3 promotes localisation of FAM122A to the nucleus, perhaps by masking the nuclear export signal (NES) that I identified. Another possibility is that 14-3-3 binding exposes a nuclear localisation signal (NLS) that was identified on FAM122A, and whose mutation …
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Solid Phase Synthesis and Biological studies on metal conjugates of bioactive peptides for targeted delivery
… affinities, efficient cellular uptake and/or nuclear targeting. Thus, in this research project, metal conjugates of some bioactive peptides were synthesized and biologically tested in order to evaluate the effects of these metal moieties on the biological activities such as the cellular …
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Fluorescence lifetime imaging microscopy to study protein aggregation in the context of neurodegenerative diseases
… where it mediates DNA repair. Mutations to its nuclear localisation signal (NLS) result in cytoplasmic mislocalisation associated with the onset of amyotrophic lateral sclerosis (ALS). Through the combined use of FLIM and single particle tracking (SPT), a tool to infer intracellular FUS …
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Biopolymer-Hybrid Nanomaterials for Vaccine Formulation
… peptides, an endosomal-escape sequence (R2H2), a nuclear localisation signal (NLS) and decaarginine (R10). Although the novel materials immobilised pDNA 2x more efficiently than Arg-PDA NPs, they failed to deliver it to HEK-293 cells, most likely due to the neutralisation of the surface charge …
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Characterisation of an acetylation-dependent FLIP/Ku70 complex that regulates FLIP expression
… (TRAIL-R2). c-FLIP binds to the death inducing signalling complex (DISC) via its tandem death effector domains (DEDs) and the DED of Fas-associated death domain-containing protein (FADD), thereby inhibiting processing of procaspases 8 and 10 at the DISC. Overexpression of c-FLIP results in the …
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Targeting the N-myc oncoprotein using nanobody technology
… and differentiation by integrating upstream signals and orchestrating global gene transcription. They do this largely through dimerising with Max, which together bind to enhancer (E)-box elements in DNA. Myc proteins function similarly but differ in potency and tissue distribution. For …
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Charakterisierung des Kerntransportsystems von Linker-Histonen
… Es wurden mehrere Kernlokalisierungssignale (NLS) in H1-Histonen identifiziert. H1 enthält wenigstens zwei verschiedene Typen von NLS, die sich beide von dem klassischen NLS-Typ unterscheiden. Der NLS-Typ 1 entspricht der wenig strukturierten, hoch-basischen C-terminalen Domäne. Der …
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Subcellular localisation and functional analysis of UVR8, a UV-B specific signalling component in Arabidopsis
… the mechanisms by which UV-B is perceived as a signal, which mediates physiological and protective responses is not yet clearly understood neither in mammals, nor in higher plants. Low fluence rates of UV-B induce the expression of genes involved in UV-protective responses such as flavonoid …