Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"nuclear imaging"”.
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Applications of machine learning in nuclear imaging and radiation detection
… some challenging problems that arise from nuclear data. Specifically, two problem areas are discussed: nuclear imaging and radiation detection. The techniques to approach these problems are primarily based on a variant of Artificial Neural Network (ANN) called Convolutional Neural Network …
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Towards nuclear imaging with polynuclear radiotracers : the development of monomeric and dendritic scaffolds for radiometals
… ligands that will permit the synthesis of multinuclear technetium-99m (99mTc) radiolabeled complexes. The ligands were synthesized by incorporating N,N-donor atom functionalities, at the periphery of DAB-PPI dendrimers, as potential 99mTc chelates. Monomeric ligands were also synthesized as …
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IN VIVO IMAGING OF STEM CELL MEDIATED TREATMENT IN A MOUSE MODEL OF SPINAL CORD INJURY
… cannot be evaluated in vivo by using classical imaging approaches. This study propose multiple labelling protocols for in vivo visualisation by MRI, nuclear imaging and BLI of adult murine neural stem cell-mediated therapy, in spinal cord injury animal models. Methods: Murine neural stem cells …
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Development of Iron Oxide Based Nanoparticles as Dual-Modality Imaging Probes
Dual-modality (MR/nuclear) imaging can combine exquisite anatomical resolution with superior molecular sensitivity, and significantly facilitate the accuracy of cancer diagnosis. However, the application of this technique is hampered by the paucity of sensitive dual-modality imaging probes that …
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In vitro evaluation of cytotoxicity and cellular uptake of alternating copolymers for use as drug delivery vehicles
… (for targeting), perfluorocarbons (19F MR imaging), fluorescent dyes (NIRF imaging), and radioiodine (nuclear imaging and radioimmunotherapy) to the backbone. Attachment of hydrocarbon or perfluorocarbon sidechains provides amphiphilicity to produce the multimodal self-assembling micelles. …
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Control and characterization of a cyclotron proton beam
… to local hospitals for cancer diagnosis and nuclear imaging. The proton beam's energy is 16.5 MeV and the diameter of the beam is approximately 1 mm. A system to control the proton beam's position has been developed by using a magnetic coil. The position of the beam can be controlled to move …
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Development of Novel Macrophage Imaging Agents
… Thus the development of macrophage-specific imaging agents has potential clinical applications in the diagnosis and measuring response to treatment of disease.<br/>This thesis sets forth the development of novel antibody-based nuclear imaging agents 99mTc-SER4, 64Cu-NOTA-SER4, and 99mTc-ED3 …
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Integration of Spatial Transcriptomics with Chromatin Images Using Graph-Based Autoencoder Identifies Joint Biomarkers for Alzheimer’s Disease
… lead to changes in cellular organization, nuclear morphology, as well as gene expression. Spatial transcriptomic technologies, such as STARmap and 10x Visium, allow the joint measurement of these different modalities in whole tissue sections.1,2 However, methods for jointly analyzing the …
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Enhancement and wavelength-shifted emission of Cerenkov luminescence using multifunctional microspheres
… microspheres for Cerenkov luminescence imaging and targeting of angiogenesis in cancer and atherosclerosis. Cerenkov luminescence imaging has gained attention as a new type of molecular imaging modality for its potential to bridge optical imaging with nuclear imaging. The engineered …
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Axial segregation of granular flows in rotating drums
… profile that is experimentally verified by the nuclear imaging technique of Positron Emission Particle Tracking. (2) The geometric slope corresponding to the gravity-driven axial flux between adjacent bands is (binomially) expanded to second order thereby ensuring band coarsening in the …
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Coordination Chemistry in Biology and Medicine
… Single Amino Acid Chelates (SAAC) for Nuclear Imaging</p> <p>Abstract.</p> <p>99mTc(I) and Re(I) complexes can be used to visualize various diseases by linking the radioactive metal cation to biologically active molecules. One type of bifunctional chelator is the single amino acid …
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Development of an MR-compatible SPECT system based on energy resolved photon counting detectors
Nuclear medicine is playing an important role in the clinical diagnosis and therapy. Single Photon Emission Computed Tomography (SPECT) is one of the most important nuclear imaging modalities, and it gives the functional imaging of the region of interest. MR can provide the anatomical imaging and …
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Hybrid pixel-waveform semiconductor detectors: novel detector readout for semiconductor pet imaging of small animal neurodegenerative models
Developing nuclear detection instrumentation for biomedically selected tasks uniquely produces a dualistic intellectual challenge: the engineering of the instrument cannot occur without mastery knowledge of its governing principles while a lack of clear understanding of the application provides an …
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A Geant4 Simulation Study Of A Xenon-Doped Liquid Argon, Full-Body, Time-of-Flight Positron Emission Tomography Scanner To Understand Its Performance And Noise Profile
… a positron emitting radiotracer. This field of nuclear imaging has seen a steady improvement of PET imaging largely due to the application of newer detection technologies and image reconstruction algorithms. However, current PET scanners possess a small field of view which limits the overall …
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The development of MRI-compatible SPECT system
In recent years, combined MRI and nuclear imaging techniques such as PET and SPECT have received great attentions. MRI provides high-resolution anatomical and functional information along with an exquisite soft tissue contrast. Nuclear techniques could provide an excellent sensitivity to …
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Multimodality Somatostatin Analog For Fluorescence-Guided Surgery In Cancer
… tumors (NETs). Anatomical and functional imaging technologies are widely used during the pre- and postoperative stages, but intraoperative disease recognition relies on direct visual inspection and the hands of surgeons. The limited number of clinical tools for real-time intraoperative …
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Towards simultaneous single emission microscopy and magnetic resonance imaging
In recent years, the combined nuclear imaging and magnetic resonance imaging (MRI) has drawn extensive research effort. They can provide simultaneously acquired anatomical and functional information inside the human/small animal body in vivo. In this dissertation, the development of an ultrahigh …
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Mammary Window Chamber Model: A Platform For Multi-Modality Cancer Imaging And Dynamic Oxygenation Assessment
… furthered the study of cancer. However, optical imaging techniques utilized with the model are limited in the depth from which light can penetrate and signal can be received. Further, ectopic placement of a xenograft in a model animal may modify the relevancy of findings by altering the normal …
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Development of amyloid beta binding bifunctional chelators for diagnosis of Alzheimer’s disease
… for the diagnosis of AD using molecular imaging modalities. Positron emission tomography (PET) is a non-invasive nuclear imaging technique that allows for measuring Aβ plaques burden in vivo using radiotracers labeled with 11C (t1/2=20.4 min), 18F (t1/2= 109.7 min), and 64Cu (t1/2 = 12.7 …
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Reconstruction Algorithms for Novel Joint Imaging Techniques in PET
… (PET) is an important functional in vivo imaging modality with many clinical applications. Its enormously wide range of applications has made both research and industry combine it with other imaging modalities such as X-ray computed tomography (CT) or magnetic resonance imaging (MRI). The …
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