Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"nuclear hormone receptors"”.
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The Regulation of Cholesterol Absorption: Nuclear Hormone Receptors and Niemann-Pick C1 Like 1
… brush border. In addition, members of the nuclear receptor superfamily of ligand-activated transcription factors are known to modulate expression of genes involved in cholesterol and bile acid homeostasis, and cholesterol absorption. Therefore, we wanted not only to clarify the essential …
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Nuclear Hormone Receptor-Mediated Changes of Cholesterol, Triglyceride, and Bile Acid Physiology in Response to Alterations in Cholesterol Absorption and Bile Acid Pool Size in Mice
… are members of a class of proteins called nuclear hormone receptors, which respond to lipophilic compounds to regulate gene transcription. I have undertaken three separate, but related projects relating to lipid metabolism with a particular focus on nuclear hormone receptor function. First, …
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Crosstalk of TTC5 cofactor and the estrogen receptor in breast cancer
… receptor, which belongs to the same familyof nuclear hormone receptors as ER. Thus, this provided the basis for the investigation ofthe role of TTC5 in ER signalling. This investigation revealed that TTC5 interacts with estrogen receptor alpha (ERa) inMCF-7 and T47D breast cancer cells, and …
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Examining the Role of DAX-1 in Regulation of Cell Proliferation in Human Breast Cells
<p>DAX-1 is a member of the Nuclear Hormone Receptor superfamily and acts as a transcriptional repressor. DAX-1 plays an important role in the development of adrenal and gonadal tissues. In addition to its role in normal cell development and differentiation, DAX-1 appears to have some influence on …
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Monitoring the Effects of the Oncogenic S250F Mutation on the Intrinsically Disordered C-terminal of FoxA1
… and modulates the transcriptional activity of nuclear hormone receptors during adulthood. FoxA1 contains a winged-helix DNA binding domain (DBD) that is flanked by two large intrinsically disordered regions (IDR). The C-terminal IDR is thought to play an important role for the pioneering …
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An In Vivo Functional Genomics Screen Identifies New Regulators of Tumorigenesis in Non-Small Cell Lung Cancer
… mini-library of 1062 lentiviral shRNAs targeting nuclear hormone receptors and their coregulators (120 genes total), we screened the lung adenocarcinoma cell line NCI-H1819 for dependency on these genes during in vitro and in vivo growth. We identified six genes required for survival in vitro …
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Molecular Dynamics Study of Hormone Receptors Binding DNA and Hormones
… and non-specific DNA, and binding/unbinding of hormones to/from retinoic acid receptor and thyroid hormone receptor. In the DNA dodecamer, d(CGCGAATTCGCG), two Adenine residues, individually or jointly, were replaced with the 2 '-deoxy-7-(hydroxymethyl)-7-deazaadenosine (hm7c 7dA) analogue. The …
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Exploration of Nuclear Receptor Activity and siRNA-Derived Phenotypes as Therapeutics in Non-Small Cell Lung Cancer
Nuclear hormone receptors are master regulators of diverse cellular functions implicated in tumor pathogenesis and as oncogenic drivers of many human cancers. To better understand what role these important receptors might be playing in lung cancer, three interconnected studies were initiated to …
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Reengineering Estrogen Receptor Hormone Specificity Through Coordinated Changes at Key Contact Sites Between Estrogen Receptor and Estradiol
The specificity of hormone action arises principally from the specific interaction that a hormonal ligand has with its cognate receptor. This interaction is defined by steric and electronic complementarity at certain sites at which portions of the ligand contact specific residues in its receptor. …
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Regulation of Metabolic Processes by Micrornas and Class I Histone Deacetylases
… the regulatory circuit formed by PGC-1beta and nuclear hormone receptors to control the overall oxidative capacity and energy homeostasis of insulin-target tissues. MiR-378/378* mutant mice do not display overt phenotypes under normal laboratory conditions, whereas their phenotypes become …
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Effects of site specific phosphorylation on the structure and functions of the glucocorticoid receptor
Ligand dependant transcription factors, like nuclear hormone receptors (NHRs), are capable of exerting transcriptional regulation in the nucleus in response to various intra- and extracellular signals. Transcription factors contain segments that are intrinsically disordered (ID) under native …
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Functional genomic analysis of PPAR-gamma in human colorectal cancer cells
… (PPAR-gamma) is a member of the super family of nuclear hormone receptors and shows much promise as a chemopreventative and therapeutic target for colorectal cancer. Activation of PPAR-gamma by thiazolidinediones (TZDs) inhibits proliferation and induces differentiation in human colon cancer …
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Roles of CCN5 in regulating progression and therapeutic sensitivity of breast cancer
… (TNBC), where the cancer cells do not express nuclear hormone receptors and human epidermal growth factor receptor 2 (HER2), have worse survival rate compared to the patients with luminal subtypes of cancer. Here, we have shown that Cysteine-rich 61-Connective Tissue Growth …
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An integrated network of estrogen receptors alpha and beta, and coregulators, for deciphering estrogen signaling in breast cancer cells
The nuclear hormone receptors, ERα and ERβ, are known to regulate the transcriptional response programs of their target cells, including breast cancer cells. However, their comparative abilities to localize at chromatin binding sites across the genome, and the recruitment of major coregulators such …
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Role of the Vitamin D Receptor in Insulin Secretion and Beta Cell Function
… (VDR, NR1I1), which is a member of the family of Nuclear Hormone Receptors (NHR). Previously, the Repa lab identified VDR as the fourth most abundant NHR in mouse islets based on mRNA levels, also, VDR is clearly present in human islets [1]. In the past years multiple epidemiological studies have …
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COMPOSTI AD AZIONE ANTI-AGGREGANTE ESERCITANO UN EFFETTO BENEFICO SU MODELLI CELLULARI DI ATROFIA MUSCOLARE SPINALE BULBARE
… This mutation leads the protein to form intranuclear aggregates in the spinal cord and brainstem and cause the death of those specific cell populations. AR belongs to the nuclear hormone receptors superfamily and it works as a transcriptional factor after binding its specific ligand …
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Site-specific phosphorylation of histone H1 associated with cell cycle progression and transcription
… rDNA promoters and is rapidly induced at steroid hormone response elements by hormone treatment. Our results imply that site-specific interphase H1 phosphorylation facilitates transcription by RNA polymerases I and II, and has an unanticipated function in ribosome biogenesis and the control of …