Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"nuclear hormone receptor"”.
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Epigenetic Regulation of Nuclear Hormone Receptor DAX-1
<p>DAX-1 (NR0B1) is an orphan nuclear receptor that plays a key role in the development and maintenance of steroidogenic tissue in mammals. Dax-1 is also expressed in mouse embryonic stem (ES) cells and is required to maintain pluripotency. Duplication of the X-chromosome in the region containing …
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Drosophila Ovarian Stem Cell Establishment is Regulated by Nuclear Hormone Receptor ftz-f1
… is known about how extrinsic signals, such as hormones, affect stem cell fate and function. The highly characterized Drosophila melanogaster steroid hormone ecdysone regulates germline stem cell (GSC) proliferation and self-renewal, as well as oogenesis and metamorphosis. Though many genes, …
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The Role of the Ubiquitin-Proteasome System in the Regulation of Nuclear Hormone Receptor-Dependent Transcription
Nukleare Hormonrezeptoren (NHRs) sind Liganden-abhängige Transkriptionsfaktoren mit breitem physiologischem sowie pathophysiologischem Funktionsspektrum. Molekulare Therapien die sich gegen NHRs richten, stellen eine optimale Behandlung einiger humaner Krankheiten dar. Der Östrogenrezeptor ist …
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Nuclear Hormone Receptor-Mediated Changes of Cholesterol, Triglyceride, and Bile Acid Physiology in Response to Alterations in Cholesterol Absorption and Bile Acid Pool Size in Mice
… are members of a class of proteins called nuclear hormone receptors, which respond to lipophilic compounds to regulate gene transcription. I have undertaken three separate, but related projects relating to lipid metabolism with a particular focus on nuclear hormone receptor function. First, …
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Estrogen Receptor Dependent Gene Regulation in Human Breast Cancer Cells
… insights into gene regulation by the estrogen receptor and cooperating factors such as PITX1. They also highlight the importance of this nuclear hormone receptor in controlling cellular functions including proliferation of breast cancer cells. These studies should assist in the development of …
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Design and Synthesis of Novel Core Scaffolds for the Development of Subtype Selective Estrogen Receptor Ligands
The Estrogen Receptor (ER) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily which plays a crucial role in bone maintenance, cardiovascular function and reproductive processes in both men and women. Although the two subtypes of ER---ERalpha and …
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Role of Abberant Proteolysis in the Pathogenesis of APL
… leukemia (PML) and the retinoic acid receptor N1 (RARN1) genes. PML-RARN1 promotes misfolding of nuclear hormone receptor corepressor (N-CoR) and that accumulation of misfolded N-CoR in the ER induces endoplasmic reticulum (ER) stress and activates unfolded protein response (UPR). …
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Light-activated gene expression
… molecules was developed. This method uses the Nuclear Hormone Receptor (NHR) family as a model system. This tool provided an opportunity to study the spatial and temporal control of genes by using small synthetic molecules and light. In the late 1990s, we first demonstrated this concept by …
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I. Design and synthesis of estrogen receptor gene switches. II. Design and synthesis of estrogen receptor ligands occupying an auxiliary binding pocket
The estrogen receptor (ER) is ligand-regulated nuclear hormone receptor and an important therapeutic target for breast cancer, hormone replacement therapy, contraception, and osteoporosis. Novel organic cores have been identified and developed as possible estrogen pharmaceuticals. The x-ray …
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Characterization of the Mechanism of PPARγ-Mediated Neointima Formation in Rodents
… GPCRs and the peroxisome proliferator-activated receptor γ (PPARγ). We pursued a gene knockout strategy to identify the LPA receptor subtypes necessary for the neointimal response in a non-injury model of carotid remodeling and also compared the effects of AGP and the PPARγ agonist rosiglitazone …
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Elucidating the Molecular Mechanisms Underlying the Hepatic Farnesoid X Receptor (FXR)-mediated Effects that Contribute to the Triglyceride-Lowering Ability of a Grape Seed Proceyanidin Extract
… triglyceride levels via activation of the nuclear hormone receptor, farnesoid x receptor (FXR), thereby increasing small heterodimer partner (SHP) messenger ribonucleic acid (mRNA) expression, which then inhibits transcription of Sterol Regulatory Element Binding Protein 1c (SREBP-1c), a …
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Examining the Role of DAX-1 in Regulation of Cell Proliferation in Human Breast Cells
<p>DAX-1 is a member of the Nuclear Hormone Receptor superfamily and acts as a transcriptional repressor. DAX-1 plays an important role in the development of adrenal and gonadal tissues. In addition to its role in normal cell development and differentiation, DAX-1 appears to have some influence on …
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Investigating C. Elegans Small-Molecule Signaling Pathways Via 2D-Nmr Based Comparative Metabolomics
… ligands have been proposed to bind to the Nuclear Hormone Receptor - DAF-12 and here using our approach we identify for the first time, the complete set of DAF-12 ligands in an unbiased and unambigious way. We then continue to investigate the biosynthetic pathway of these ligands and …
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Regulation of proliferation, apoptosis, and metastasis in prostate cancer cells by DAX-1 (NR0B1)- an androgen-induced orphan nuclear receptor
… gene 1) is an unusual member of the Nuclear Hormone Receptor superfamily that has the ability to interact with other Nuclear Receptors (NRs) and transcriptional co-repressors and co-activators. While DAX-1 plays an important role in adrenal and gonadal development, recent studies have …
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Transcriptional Regulation by DAX-1 in Pluripotent and Differentiated Cells
<p>DAX-1, an orphan nuclear hormone receptor, acts mainly as a repressor through transcriptional protein complexes. Its unique structure and specific expression raises questions as to what its precise interactions are and how it mediates its repressive function. While it is known to play a role in …
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Investigating the Effects of Sodium Benzoate on Fat Deposition, Pharyngeal Pumping, and Related Genetic Mechanisms in Caenorhabditis elegans
… of fatty acids, insulin signaling pathway, nuclear hormone receptor, and Krüppel-like zinc finger transcription factors but no significant difference was found in gene expression levels. These results therefore led to the conclusion that sodium benzoate may have obesogenic effects as …
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Identification of Ligands for the Orphan Nuclear Receptor DAF-12 That Govern Dauer Formation and Reproduction in C. Elegans
The orphan nuclear hormone receptor, DAF-12, plays a central role in the physiology of free-living nematode, C. elegans. DAF-12 is best known for its role in regulating dauer formation, a non-reproductive larval state entered in harsh environments and marked by developmental arrest, stress …
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The role of orphan nuclear receptor DAX-1 (NR0B1) in human breast cancer cells: expression, proliferation and metastasis
<p>The orphan nuclear hormone receptor DAX-1 (Dosage Sensitive Sex Reversal, Adrenal Hypoplasia Congenita on the X Chromosome, gene 1) plays an important role in the development of adrenal and gonadal tissues and functions as a global negative-regulator of steroidogenesis. In addition, it is known …
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Effects of lower- and higher- volume resistance exercise on serum testosterone and skeletal muscle androgen receptor content in men : subsequent effects on the mRNA expression of insulin- like growth factor peptide and myostatin in skeletal muscle.
Testosterone is the primary sex steroid hormone within males. Testosterone effects are ubiquitous and are categorized as either anabolic or androgenic. The androgen receptor is a specific nuclear hormone receptor through which testosterone elicits its effects. Specifically, skeletal muscle has …
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Regulation of C. elegans behavior and physiology by the hypoxia-response pathway
… for suppressors of cyp-36A1(lf) identified the nuclear hormone receptor NHR-46. We propose that CYP-36A1 functions as a hormone biosynthetic enzyme for the ligand of this receptor, thus mediating gene expression changes that alter stress physiology and behavior. We also found site-of-action and …
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