Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"nuclear factor-κB"”.
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Cerebrovascular and Neuronal Cellular Consequences of Amyloid-β Induced Nuclear Factor-κB Activation
… significant role in inflammatory responses, the nuclear factor-κB (NF-κB) pathway is hypothesized to play such a regulatory function in AD.</p> <p>The work presented here examines the cellular activation of NF-κB by Aβ aggregates in both cerebrovascular and neuronal cells. Small Aβ aggregates …
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Dissecting the Role of Novel O-GlcNAcylation of NF-κB in Pancreatic Cancer
… treatment options for PDAC patients. The nuclear factor κB (NF-κB) is a crucial transcription factor that is constitutively activated in PDAC. It mediates the transcription of oncogenic and inflammatory genes that facilitate multiple PDAC phenotypes. Thus, a better understanding of the …
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Genetic Approach to Discover ARMC4 as a Novel NF-κB Negative Regulator and Tumor Suppressor in Colorectal Cancer
The nuclear factor κB (NF-κB) plays pivotal roles in inflammatory and immune responses and in cancer. Therefore, understanding its regulation holds great promise for disease therapy. Using validation-based insertional mutagenesis (VBIM), a powerful technique established by us, we discovered …
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Identification of Anti-inflammatory and Antioxidant Properties of MangostinXanthones in Adipocyte Reporter Assays
… on a 3T3-L1 cell line that stably expressed nuclear factor κB response element (<i>Nfkb</i>-RE)/GFP, fatty acid binding protein 4 promoter (<i>Fabp4</i>-P)/CFP, and nuclear factor erythroid 2-related factor2 promoter (<i>Nrf2</i>-P)/YFP fluorescent reporters. We hypothesized that fluorescent …
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Validation-based insertional mutagenesis (VBIM) technology identifies adenomatous polypossis coli (APC) like protein (ALP) as a novel negative regulator of NF-κB
… cancer related deaths in the United States. The nuclear factor κB (NF-κB) is an important family of transcription factors whose aberrant activation has been found in many types of cancer, including CRC. Therefore, understanding the regulation of NF-κB is of ultimate importance for cancer therapy. …
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A study of bioprocess designs for development of the myogenic secretome as a source of bioactive extracellular vesicles
… of EVs on matrix metalloproteinase-13 and nuclear factor-κB gene expression and EV ability to limit degradation of collagen II in tumour necrosis factor-α treated chondrocytes was also assessed. Potential mechanisms of action of HSMM secretome proteins were investigated by predicting their …
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Role of Toll-Like Receptor 4 in Oxidant-induced Inflammatory Phenotypes in Macrophages
… role of TLR4 in exogenous oxidant induced nuclear factor-κB (NF-κB) activation in macrophage RAW-Blue cells with stable transfection of NF-κB reporter gene SEAP. Our results show that inhibition of TLR4 significantly attenuated oxidant-induced NF-κB activation, which caused an imbalance in …
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Regulation of Hepatic Drug Transporters Expression in Mice During Acute Inflammation
… with inflammation. Pregnane X receptor (PXR) and nuclear factor-κB (NF-κB) are regarded as key transcriptional factors that are modulated in response to endotoxin and cytokine signaling. This work assesses the role of NF-κB and PXR in the transcriptional regulation of hepatic transporters and …
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Plasticity of Adrenal Chromaffin Cell Function During Inflammation and Exposure to Microbe-Associated Molecular Patterns
… were mediated by Toll-like receptor 4 and nuclear factor-κB. In summary, GI and systemic inflammation produce opposite effects on ACC Ca2+ signaling through distinct mechanisms, and ACCs can directly detect MAMPs. These findings extend our knowledge of the complex integration performed by …
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NOVEL CINNAMIC ACID-BASED DEHYDROPOLYMERS FOR EMPHYSEMA: IN VITRO AND IN VIVO ASSESSMENT OF THEIR ACTIVITIES
… (Calu-3) repression of pro-inflammatory nuclear factor κB (NFκB) upon its plasmid transfection and chromogenic substrate NE hydrolysis, respectively. The sulfated caffeic acid DHP, CDS was shown to be the most potent in all three assessments, yielding the half-maximal inhibitory …
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Role of Microglial α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulator in Neuroinflammatory Pain Models in Mice
… B, a downstream mediator that decreases due to nuclear factor-κB (NF-κB) inactivation, and p-NF-κB p65 expression in the hippocampus. In addition, TQS reduced the expression of tumor necrosis factor (TNF) and increased the level of norepinephrine in the hippocampus. We determined that TQS …
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Biological and Chemical Investigation of Panamanian Plants for Potential Utility against Metabolic Syndrome
… receptors (PPARs), liver X receptors (LXRs), nuclear factor-κB (NF-κB), and inducible nitric oxide synthase (iNOS) which are key regulators of various processes leading to metabolic disorder and inflammation. As a part of inflammatory pathway, activation of NF-κB leads to insulin resistance …
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EVALUATION OF YAK-KONG SOYBEAN (GLYCINE MAX) FOR ITS PHENOLICS AND METABOLITES WITH A FOCUS ON ATHEROSCLEROSIS PREVENTION
… adhesion of THP-1 monocytes to tumor necrosis factor (TNF)-α-stimulated human umbilical vein endothelial cells (HUVECs). DHPV downregulated TNF-α-stimulated expressions of vascular cell adhesion molecule-1 (VCAM-1), monocyte chemotactic protein-1 (MCP-1) and activation of nuclear factor-κB …
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VALORIZATION OF CHESTNUT BY-PRODUCT FOR GASTROINTESTINAL HEALTH
… with key targets of inflammation, including the nuclear factor κB (NF-κB). A promising role as a further therapeutical target for gut disorders has been recently proposed for the regulatory subunit of hypoxia-inducible factor (HIF-1α), as a potential stabilizer of intestinal barrier integrity. …
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In vitro and in vivo investigation of the anticancer activity and molecular mechanisms of disulfiram in non-small cell lung cancer
… that tumour hypoxia induced activation of the nuclear factor-κB (NF-κB) pathway; a pivotal regulator of CSCs. Therefore, development of an NF-κB and CSC targeting drug will improve NSCLC therapeutic outcomes. New drug development is an expensive and time-consuming procedure. DS demonstrates …
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The Cellular Mirna, Mir-190, is Upregulated in Type I Ebv Latency by Ebers and Modulates Cellular Mrnas involved in Cell Survival and Viral Reactivation
… reporters that lacked YinYang1 (YY1) and Nuclear factor-κB (NF-kB) binding motifs. In the presence of EBERs, promoters with these deleted binding motifs had lowered activation compared to the full miR-190/TLN2 promoter. This work describes a mechanism by which EBERs upregulate a cellular …
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Inhibition of Heat Shock Protein 90 Reduces Inflammatory Signal Transduction in Murine J774 Macrophage Cells and Lessens Disease in Autoimmune MRL/lpr Mice: What in vitro, in vivo, and in silico Models Reveal
… and TNF-α. Inhibition of HSP90 also prevented nuclear translocation of NF-κB. To investigate the anti-inflammatory effects of HSP90 inhibition in vivo, MRL/lpr lupus mice were administered 5 mg/kg 17-DMAG for six weeks via intraperitoneal injection. Mice treated with 17-DMAG were found to have …
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Regulation of Antimicrobial Peptide Genes in the Tobacco Hornworm Manduca sexta
… in M. sexta. Dorsal and Relish belong to the nuclear factor-κB (NF-κB)/Rel family. I showed that M. sexta Dorsal and Rel2 (Relish) isoforms could regulate AMP genes differently, and Dorsal and Rel2 could form heterodimers, which negatively regulated AMP genes. This is a novel finding about …
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PLGA-DS reverses chemoresistance in malignant mesothelioma by targeting hypoxia induced cancer stem cells
… by asbestos activates a key transcription factor, nuclear factor-κB (NF-κB), which is further upregulated in cancer stem cells (CSCs) by hypoxia. Both hypoxia and NF-κB pathway plays a pivotal role in the maintenance of stemness in hypoxia-induced CSCs leading to upregulation of …
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Novel mechanism of gastric proton pump inhibitor (PPI) : Suppression of Helicobacter-pylori induced angiogenesis and selective induction of apoptosis in gastric cancer cells.
… patients. Expression of hypoxia inducible factor 1 (HIF-1α) and vascular endothelial growth factor (VEGF) was tested by reverse transcription-polymerase chain reaction and secretion of interleukin 8, and VEGF was measured by ELISA. To evaluate the direct effect of H.pylori infection on the …
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