Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"nuclear bodies"”.
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A Study of the Biosynthetic Capabilities of Isolated Bacterial Nuclear Bodies
Made available in DSpace on 2014-12-05T21:45:30Z (GMT). No. of bitstreams: 1 5902017.pdf: 3977447 bytes, checksum: 9d82b74dad0a20692ee454b209691f3a (MD5) Previous issue date: 1959
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Subnucleäre Lokalisation des Transkriptionsfaktors STAT3
… to enhancer sequences of target genes. * The subnuclear localization of the transcription factor STAT3 was analyzed by confocal laserscanning microscopy. Activated STAT3 was found in dot-like structures within the nucleus which were termed STAT3 nuclear bodies. * The fusion protein STAT3-YFP was …
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Modelling Nuclear Body Dynamics in Living Cells by 4-D Microscopy, Image Analysis and Simulation
… demonstrates rules of and validates models for nuclear body (NB) dynamics. Simulation tools developed in the course of this work can be used in future work to generate hypotheses about related aspects of nuclear architecture. Initially I examined the mobility of vimentin nuclear bodies bodies …
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Analysis of the Role of Akirin Interactions with Nuclear Body Proteins During Myogenesis
<p>Akirin is a highly conserved, small nuclear protein of indeterminate structure ubiquitously expressed in non-fungal eukaryotic species. It was first discovered in the innate immune response, but many other functions have since been found, including embryonic muscle patterning and myogenesis. …
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Studio delle modificazioni post-traduzionali della proteina AIRE e dell’effetto sulla sua attività trascrizionale, stabilità e localizzazione cellulare
… have shown that AIRE-CBP interaction occurs in nuclear bodies and increases the expression of its target genes (Akiyoshi H et al 2004), (Pitkänen J. et al 2005), (Ferguson BJ et al 2008). More recently, the role of p300 in AIRE acetylation, which could influence the selection of AIRE activated …
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Data-driven Mechanistic Modeling of 3D Human Genome
… biological processes, such as the coalescence of nuclear bodies. This thesis is organized as follows. In the first chapter, we introduce a computational model to simulate chromatin structure and dynamics. The model defines chromatin states by taking one-dimensional genomics and epigenomics data as …
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Multiscale Modeling of Genome Organization: Bridging Polymer Physics, Molecular Dynamics, and AI
… apply computational frameworks to investigate nuclear genome organization at high spatial and temporal resolution. Our approaches integrate biophysical modeling and generative artificial intelligence to address complementary aspects of nuclear architecture. In Chapter 1, we provide an overview …
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Novel Single Cell Methods to Identify the Genetic Composition at a Single Nuclear Structure
… or the ligation of oligo probes to subnuclear sites of double stranded breaks induced by 2-photon irradiation. It is demonstrated that these techniques afford the ability to identify loci occupying a shared site at a single nuclear substructure, and are thus uniquely suited for …
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Identifizierung und funktionelle Charakterisierung des Spleißfaktors SRp30c als Interaktionspartner des Y-box-Proteins-1 (YB-1)
… which SRp30c accumulates in stress-induced Sam68 nuclear bodies, abrogates the co-localization and YB-1 shuttles back to the cytoplasm. Finally, the functional relevance of the YB-1/SRp30c interaction for in vivo splicing is demonstrated in the E1A minigene model system. Here, changes in splice …
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Compositional Control of Phase-Separated Cellular Bodies
Cellular bodies such as P bodies and PML nuclear bodies (PML NBs) appear to be phase separated liquids organized by multivalent interactions among proteins and RNA molecules. Although many components of various cellular bodies are known, general principles that define body composition are lacking. …
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Lokalisation des antiviralen Mx1 Proteins und seiner assoziierten Proteinkinase in nukleären Einschlusskörperchen
… des SUMO-1-Systems und der sogenannten PML Nuclear Bodies (PML NBs). <br>Im Rahmen der vorliegenden Dissertation konnte durch konfokale Mikroskopie eine enge morphologische Assoziation von Mx1 zu den Proteinen der PML NBs und des SUMO-1-Systems gezeigt werden. Diese morphologischen Befunde …
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Regulation of NF-κB by PML and PML-RARα
… of NF-κB. Promyelocytic Leukemia (PML) is a nuclear protein that forms nuclear bodies (PML NBs), sub-nuclear structures that are associated with transcriptionally active genomic regions that have been implicated in multiple processes such as apoptosis, senescence and anti-viral responses. A …
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The Role of the RNA-binding Protein ZFP36L1 in Suppression of Replication Stress-induced Genomic Instability
… an elevated accumulation of γH2AX, 53BP1 nuclear bodies (NBs) and RPA, which indicated an active role for ZFP36L1 in limiting replication stress-induced DNA damage. Furthermore, we demonstrated an unanticipated function for ZFP36L1 in potentially suppressing the expression of common …
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Studying Tissue Specific Diversity of Splicing Regulator Muscleblind
… Intracellular localization of Mbl was typically nuclear, however in the nervous system the protein was strongly expressed in the cytoplasm. During early adult development in the pupa, in various tissues Mbl was initially detected in discrete nuclear bodies, before it assumed more general nuclear …
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Post-Replicative Resolution of Under-Replication
… number of ultrafine anaphase bridges and 53BP1 nuclear bodies are in remarkable concordance with the theoretical predictions for the number of double fork stalls, indicating that cells are able to tolerate under-replication through such post-replicative cellular responses. 53BP1 preferentially …
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Functional analysis of murine CD43 shedding : a role for the CD43 cytoplasmic tail in nuclear signalling
… to determine the functional significance of CD43 nuclear translocation and SUMO modification, we examined nuclei from hemopoietic cells more closely and observed that the CD43 cytoplasmic tail is localized in a subnuclear structure called promyelocytic nuclear bodies, which control many nuclear …
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Npsd4: A New Player In Sumo-Dependent Dna Repair
… (SIMs). In addition, I found that NPSD4 is a nuclear protein and can localize to the SUMOylated promyelocytic leukemia nuclear bodies (PML NBs) in a SIM-dependent manner. With collaboration in the lab, we show that NPSD4 interacts with and regulates the protein levels of BLM helicase, an …
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Functional analyses of hTel2 and TRF2 deltaB: Insights Into the Role of a New DNA Damage Pathway and Homologous Recombination in Mammalian Telomere Function
… of human cells where it was enriched in PML nuclear bodies, but telomeres. Surprisingly, hTel2 also localized to centrosomes. Although hTel2 did not detectably interact with telomeric proteins or telomeric chromatin, the overexpression untagged hTel2 resulted in the slow elongation of …
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The Adenylate-Uridylate-Rich element RNA binding protein ZFP36L1 suppresses replication stress-induced genomic instability
… ZFP36L1 that demonstrated suppression of 53BP1 nuclear bodies (NBs) and micronuclei formation. Importantly, we demonstrate, by overexpression of a catalytically inactive mutant of human RNase H1 tagged with GFP that loss of ZFP36L1 induces R-loop formation. We also implicate unscheduled R-loop …
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53BP1 and double-strand break repair pathway choice in cancer
… accumulation of acentric micronuclei and G1 nuclear bodies. We propose that the functional sequestration of TOPBP1 may be responsible for these chromosomal mis-segregation defects. The mechanism by which 53BP1 (together with RIF1 and MAD2L2) promote NHEJ remains elusive. Genome instability in …
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