Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"nsp1"”.
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Mechanism of transmissible gastroenteritis virus nsp1-mediated translation inhibition
The non-structural protein 1 (nsp1) proteins of several coronaviruses share a common property to inhibit host gene expression, but use different mechanisms to exert this function. Unlike the nsp1 protein of SARS coronavirus, a group 2b betacoronavirus, the nsp1 protein of transmissible …
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Innate immune evasion and interferon antagonism by porcine epidemic diarrhea virus
… and of 16 PEDV nonstructural proteins (nsps), nsp1, nsp3, nsp7, nsp14, nsp15, and nsp16 were found to inhibit the IFN-β and IRF3 promoter activities. The sole accessory protein ORF3 and the envelope (E), membrane (M), and nucleocapsid (N) proteins were also determined to inhibit such …
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Cell-Specific Inhibition of Interferon Production by Rotavirus
… Rotavirus non-structural protein 1 (NSP1) is responsible for viral evasion of the innate immune system, the first line of defence against invading pathogens. The activated immune system produces interferon (IFNs), a cytokine that drives expression of antiviral effectors, known as …
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Impact of mutations in non-structural proteins on SARS-CoV-2 replication
… on mutations in the several NSPs including NSP1, 2, 3, 13,14, and 15 of the early Omicron (BA.1) and XBB 1.5 variants and investigated their impact on structure and the functional implications using bioinformatics tools and protein structure prediction methods. Our analysis focused on …
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Use of an Atg16l1 mouse model to study the role played by autophagy in neuroprotection
… in organotypic brain slice cultures while viral nsP1 and capsid expression was reduced in Atg16l1 KO embryonic fibroblast cultures. Semliki Forest Virus markers did not colocalize with autophagosomes in autophagy competent cells. While Semliki Forest Virus causes widespread encephalitis in vivo, …
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Innate immune modulation and pathogenic basis for porcine reproductive and respiratory syndrome virus
… its survival during infection, and the nsp1 protein of PRRSV has been identified as the potent IFN antagonist. The nsp1β subunit of nsp1 blocks the host mRNA nuclear export and this is one of the viral mechanisms to inhibit host antiviral protein translation. The functional motif for …
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Inactivation mechanisms of human norovirus surrogate Tulane virus by peracetic acid at different pHs
… correlation between the reduction of TV and TV NSP1 genes suggested that genome damage is only responsible for approximately 10% of TV inactivation. These results indicated that the combination of the genome and spike protein damage did not fully explain inactivation. The findings in this study …
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A reverse genetics study of the Human Coronavirus 229E ADP-ribose-1"-phosphatase
… or mutant forms of the HCoV-229E pp1a/pp1ab nsp1-to-nsp4 region revealed that PLP2 is responsible for processing at the predicted nsp3|nsp4 cleavage site while PLP1 does not cleave at this site. The data provide new insight into HCoV-229E PLP substrate specificities and polyprotein processing …